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71.
PER ALSTRÖM ISAO NISHIUMI YOSHIMITSU SHIGETA KEISUKE UEDA MARTIN IRESTEDT MATS BJÖRKLUND URBAN OLSSON 《Ibis》2011,153(2):395-410
The Arctic Warbler Phylloscopus borealis breeds across the northern Palaearctic and northwestern‐most Nearctic, from northern Scandinavia to Alaska, extending south to southern Japan, and winters in Southeast Asia, the Philippines and Indonesia. Several subspecies have been described based on subtle morphological characteristics, although the taxonomy varies considerably among different authors. A recent study (T. Saitoh et al. (2010) BMC Evol. Biol. 10 : 35) identified three main mitochondrial DNA clades, corresponding to: (1) continental Eurasia and Alaska, (2) south Kamchatka, Sakhalin and northeast Hokkaido, and (3) most of Japan (Honshu, Shikoku, Kyushu). These three clades were estimated to have diverged during the late Pliocene to early Pleistocene (border at c. 2.6 million years ago). Differences in morphometrics have also been reported among members of the three clades (T. Saitoh et al. (2008) Ornithol. Sci. 7 : 135–142). Here we analyse songs and calls from throughout the range of the Arctic Warbler, and conclude that these differ markedly and consistently among the populations representing the three mitochondrial clades. Kurile populations, for which no sequence data are available, are shown to belong to the second clade. To determine the correct application of available scientific names, mitochondrial DNA was sequenced from three name‐bearing type specimens collected on migration or in the winter quarters. Based on the congruent variation in mitochondrial DNA, morphology and vocalizations, we propose that three species be recognized: Arctic Warbler Phylloscopus borealis (sensu stricto) (continental Eurasia and Alaska), Kamchatka Leaf Warbler Phylloscopus examinandus (Kamchatka (at least the southern part), Sakhalin, Hokkaido and Kurile Islands), and Japanese Leaf Warbler Phylloscopus xanthodryas (Japan except Hokkaido). 相似文献
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This paper analyses a recent mathematical model of avascular tumour spheroid growth which accounts for both cell cycle dynamics
and chemotactic driven cell movement. The model considers cells to exist in one of two compartments: proliferating and quiescent,
as well as accounting for necrosis and apoptosis. One particular focus of this paper is the behaviour created when proliferating
and quiescent cells have different chemotactic responses to an extracellular nutrient supply. Two very different steady-state
behaviours are identified corresponding to those cases where proliferating cells move either more quickly or more slowly than
quiescent cells in response to a gradient in the extracellular nutrient supply. The case where proliferating cells move more
rapidly leads to the commonly accepted spheroid structure of a thin layer of proliferating cells surrounding an inner quiescent
core. In the case where proliferating cells move more slowly than quiescent cells the model predicts an interesting structure
of a thin layer of quiescent cells surrounding an inner core of proliferating and quiescent cells. The sensitivity of this
tumour structure to the cell cycle model parameters is also discussed. In particular variations in the steady-state size of
the tumour and the types of transient behaviour are explored. The model reveals interesting transient behaviour with sharply
delineated regions of proliferating and quiescent cells. 相似文献
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T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?
Zana Brkic Odilia BJ Corneth Cornelia G van Helden-Meeuwsen Radboud JEM Dolhain Naomi I Maria Sandra MJ Paulissen Nadine Davelaar Jan Piet van Hamburg Paul L van Daele Virgil A Dalm P Martin van Hagen Johanna MW Hazes Marjan A Versnel Erik Lubberts 《Arthritis research & therapy》2014,16(2):R62
Introduction
A hallmark of systemic autoimmune diseases like systemic lupus erythematosus (SLE) is the increased expression of interferon (IFN) type I inducible genes, so-called IFN type I signature. Recently, T-helper 17 subset (Th17 cells), which produces IL-17A, IL-17F, IL-21, and IL-22, has been implicated in SLE. As CCR6 enriches for Th17 cells, we used this approach to investigate whether CCR6+ memory T-helper cells producing IL-17A, IL-17F, IL-21, and/or IL-22 are increased in SLE patients and whether this increase is related to the presence of IFN type I signature.Methods
In total, 25 SLE patients and 15 healthy controls (HCs) were included. SLE patients were divided into IFN type I signature-positive (IFN+) (n = 16) and negative (IFN-) (n = 9) patients, as assessed by mRNA expression of IFN-inducible genes (IFIGs) in monocytes. Expression of IL-17A, IL-17F, IL-21, and IL-22 by CD4+CD45RO+CCR6+ T cells (CCR6+ cells) was measured with flow cytometry and compared between IFN+, IFN- patients and HCs.Results
Increased percentages of IL-17A and IL-17A/IL-17F double-producing CCR6+ cells were observed in IFN+ patients compared with IFN- patients and HCs. IL-17A and IL-17F expression within CCR6+ cells correlated significantly with IFIG expression. In addition, we found significant correlation between B-cell activating factor of the tumor necrosis family (BAFF)–a factor strongly correlating with IFN type I - and IL-21 producing CCR6+ cells.Conclusions
We show for the first time higher percentages of IL-17A and IL-17A/IL-17F double-producing CCR6+ memory T-helper cells in IFN+ SLE patients, supporting the hypothesis that IFN type I co-acts with Th17 cytokines in SLE pathogenesis. 相似文献76.
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A Copeland X Zhang M Misra A Lapidus M Nolan S Lucas S Deshpande JF Cheng R Tapia LA Goodwin S Pitluck K Liolios I Pagani N Ivanova N Mikhailova A Pati A Chen K Palaniappan M Land L Hauser C Pan CD Jeffries JC Detter EM Brambilla M Rohde OD Djao M Göker J Sikorski BJ Tindall T Woyke J Bristow JA Eisen V Markowitz P Hugenholtz NC Kyrpides HP Klenk K Mavromatis 《Standards in genomic sciences》2012,6(2):145-154
Runella slithyformis Larkin and Williams 1978 is the type species of the genus Runella, which belongs to the Cytophagaceae, a family that was only recently classified to the order Cytophagales in the class Cytophagia. The species is of interest because it is able to grow at temperatures as low as 4°C. This is the first completed genome sequence of a member of the genus Runella and the sixth sequence from the family Cytophagaceae. The 6,919,729 bp long genome consists of a 6.6 Mbp circular genome and five circular plasmids of 38.8 to 107.0 kbp length, harboring a total of 5,974 protein-coding and 51 RNA genes and is a part of the Genomic Encyclopedia of Bacteria and Archaea project. 相似文献
79.
Copeland A Gu W Yasawong M Lapidus A Lucas S Deshpande S Pagani I Tapia R Cheng JF Goodwin LA Pitluck S Liolios K Ivanova N Mavromatis K Mikhailova N Pati A Chen A Palaniappan K Land M Pan C Brambilla EM Rohde M Tindall BJ Sikorski J Göker M Detter JC Bristow J Eisen JA Markowitz V Hugenholtz P Kyrpides NC Klenk HP Woyke T 《Standards in genomic sciences》2012,6(1):21-30
Marinithermus hydrothermalis Sako et al. 2003 is the type species of the monotypic genus Marinithermus. M. hydrothermalis T1(T) was the first isolate within the phylum "Thermus-Deinococcus" to exhibit optimal growth under a salinity equivalent to that of sea water and to have an absolute requirement for NaCl for growth. M. hydrothermalis T1(T) is of interest because it may provide a new insight into the ecological significance of the aerobic, thermophilic decomposers in the circulation of organic compounds in deep-sea hydrothermal vent ecosystems. This is the first completed genome sequence of a member of the genus Marinithermus and the seventh sequence from the family Thermaceae. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 2,269,167 bp long genome with its 2,251 protein-coding and 59 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project. 相似文献
80.
Anderson I Tindall BJ Rohde M Lucas S Han J Lapidus A Cheng JF Goodwin L Pitluck S Peters L Pati A Mikhailova N Pagani I Teshima H Han C Tapia R Land M Woyke T Klenk HP Kyrpides N Ivanova N 《Standards in genomic sciences》2012,6(1):31-42
Halopiger xanaduensis is the type species of the genus Halopiger and belongs to the euryarchaeal family Halobacteriaceae. H. xanaduensis strain SH-6, which is designated as the type strain, was isolated from the sediment of a salt lake in Inner Mongolia, Lake Shangmatala. Like other members of the family Halobacteriaceae, it is an extreme halophile requiring at least 2.5 M salt for growth. We report here the sequencing and annotation of the 4,355,268 bp genome, which includes one chromosome and three plasmids. This genome is part of a Joint Genome Institute (JGI) Community Sequencing Program (CSP) project to sequence diverse haloarchaeal genomes. 相似文献