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911.
The molecular basis of HbH disease in Taiwan 总被引:1,自引:0,他引:1
Hong-Wen Peng Shou-Hwa Han Teh-Yuan Chow Chao-Hung Ho King-Nien Ching Benjamin N. Chiang 《Human genetics》1988,78(2):137-139
Summary We have determined the molecular characteristics of -thalassemia in 12 HbH subjects from Taiwan by restriction endonuclease mapping with -and -specific probes. We have found four types of defects in the -thalassemia-2 genetic determinant: 3.7 type I; 4.2; CS; and T. All HbH subjects carried the ——SEA genotype in the -thalassemia-1 determinant. At least two different subtypes of ——SEA genotype were observed in this study. 相似文献
912.
Jiun-Yang Chiang Jenq-Wen Huang Lian-Yu Lin Chin-Hao Chang Fang-Ying Chu Yen-Hung Lin Cho-Kai Wu Jen-Kuang Lee Juei-Jen Hwang Jiunn-Lee Lin Fu-Tien Chiang 《PloS one》2016,11(2)
Background and Objectives
Patients with severe kidney function impairment often have autonomic dysfunction, which could be evaluated noninvasively by heart rate variability (HRV) analysis. Nonlinear HRV parameters such as detrended fluctuation analysis (DFA) has been demonstrated to be an important outcome predictor in patients with cardiovascular diseases. Whether cardiac autonomic dysfunction measured by DFA is also a useful prognostic factor in patients with end-stage renal disease (ESRD) receiving peritoneal dialysis (PD) remains unclear. The purpose of the present study was designed to test the hypothesis.Materials and Methods
Patients with ESRD receiving PD were included for the study. Twenty-four hour Holter monitor was obtained from each patient together with other important traditional prognostic makers such as underlying diseases, left ventricular ejection fraction (LVEF) and serum biochemistry profiles. Short-term (DFAα1) and long-term (DFAα2) DFA as well as other linear HRV parameters were calculated.Results
A total of 132 patients (62 men, 72 women) with a mean age of 53.7±12.5 years were recruited from July 2007 to March 2009. During a median follow-up period of around 34 months, eight cardiac and six non-cardiac deaths were observed. Competing risk analysis demonstrated that decreased DFAα1 was a strong prognostic predictor for increased cardiac and total mortality. ROC analysis showed that the AUC of DFAα1 (<0.95) to predict mortality was 0.761 (95% confidence interval (CI). = 0.617–0.905). DFAα1≧ 0.95 was associated with lower cardiac mortality (Hazard ratio (HR) 0.062, 95% CI = 0.007–0.571, P = 0.014) and total mortality (HR = 0.109, 95% CI = 0.033–0.362, P = 0.0003).Conclusion
Cardiac autonomic dysfunction evaluated by DFAα1 is an independent predictor for cardiac and total mortality in patients with ESRD receiving PD. 相似文献913.
Melanoma central nervous system metastases: current approaches,challenges, and opportunities
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Justine V. Cohen Hussain Tawbi Kim A. Margolin Ravi Amravadi Marcus Bosenberg Priscilla K. Brastianos Veronica L. Chiang John de Groot Isabella C. Glitza Meenhard Herlyn Sheri L. Holmen Lucia B. Jilaveanu Andrew Lassman Stergios Moschos Michael A. Postow Reena Thomas John A. Tsiouris Patrick Wen Richard M. White Timothy Turnham Michael A. Davies Harriet M. Kluger 《Pigment cell & melanoma research》2016,29(6):627-642
Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area. 相似文献
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Tin-Kan Hung Ruei-Hung Kuo Cheng-Hsien Chiang 《Molecular & cellular biomechanics : MCB》2020,17(1):19-24
Kinematic and dynamic characteristics of pulsating flow in a model of
human aortic arch are obtained by a computational analysis. Three-dimensional
flow processes are summarized by pressure distributions on the symmetric plane
together with velocity and pressure contours on a few cross sections for systolic
acceleration and deceleration. Without considering the effects of aortic tapering
and the carotid arteries, the development of tubular boundary layer with
centrifugal forces and pulsation are also analyzed for flow separation and
backflow during systolic deceleration. 相似文献
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Jonathan W. Lockner Sam On Ho Karen C. McCague Su Ming Chiang Thai Q. Do Gary Fujii Kim D. Janda 《Bioorganic & medicinal chemistry letters》2013,23(4):975-978
A major liability of existing nicotine vaccine candidates is the wide variation in anti-nicotine immune responses among clinical trial participants. In order to address this liability, significant emphasis has been directed at evaluating adjuvants and delivery systems that confer more robust potentiation of the anti-nicotine immune response. Toward that end, we have initiated work that seeks to exploit the adjuvant effect of liposomes, with or without Toll-like receptor agonist(s). The results of the murine immunization study described herein support the hypothesis that a liposomal nicotine vaccine formulation may provide a means for addressing the immunogenicity challenge. 相似文献
920.
Haoyi Wu Sum Wai Chiang Cheng Yang Ziyin Lin Jingping Liu Kyoung-Sik Moon Feiyu Kang Bo Li Ching Ping Wong 《PloS one》2015,10(8)
Electrically small antennas (ESAs) are becoming one of the key components in the compact wireless devices for telecommunications, defence, and aerospace systems, especially for the spherical one whose geometric layout is more closely approaching Chu’s limit, thus yielding significant bandwidth improvements relative to the linear and planar counterparts. Yet broad applications of the volumetric ESAs are still hindered since the low cost fabrication has remained a tremendous challenge. Here we report a state-of-the-art technology to transfer electrically conductive composites (ECCs) from a planar mould to a volumetric thermoplastic substrate by using pad-printing technology without pattern distortion, benefit from the excellent properties of the ECCs as well as the printing-calibration method that we developed. The antenna samples prepared in this way meet the stringent requirement of an ESA (ka is as low as 0.32 and the antenna efficiency is as high as 57%), suggesting that volumetric electronic components i.e. the antennas can be produced in such a simple, green, and cost-effective way. This work can be of interest for the development of studies on green and high performance wireless communication devices. 相似文献