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991.
Letavic MA Keith JM Jablonowski JA Stocking EM Gomez LA Ly KS Miller JM Barbier AJ Bonaventure P Boggs JD Wilson SJ Miller KL Lord B McAllister HM Tognarelli DJ Wu J Abad MC Schubert C Lovenberg TW Carruthers NI 《Bioorganic & medicinal chemistry letters》2007,17(4):1047-1051
A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed. 相似文献
992.
Black LA Nersesian DL Sharma P Ku YY Bennani YL Marsh KC Miller TR Esbenshade TA Hancock AA Cowart M 《Bioorganic & medicinal chemistry letters》2007,17(5):1443-1446
4-[6-(2-Tertiaryaminoethyl)naphthalen-2-yl]benzonitriles are conformationally constrained histamine H3 receptor antagonists with high potency and selectivity. The analogs were designed around a naphthalene core, with the goal of enhancing lipophilicity and CNS penetration, as compared to a previously reported benzofuran series. The SAR of the tertiary amine moiety is similar to that reported for the benzofuran series, with analogs bearing a 2-methylpyrrolidine substituent possessing the greatest rat and human H3 receptor binding affinities. 相似文献
993.
Cantin LD Magnuson S Gunn D Barucci N Breuhaus M Bullock WH Burke J Claus TH Daly M Decarr L Gore-Willse A Hoover-Litty H Kumarasinghe ES Li Y Liang SX Livingston JN Lowinger T Macdougall M Ogutu HO Olague A Ott-Morgan R Schoenleber RW Tersteegen A Wickens P Zhang Z Zhu J Zhu L Sweet LJ 《Bioorganic & medicinal chemistry letters》2007,17(10):2869-2873
Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit increased insulin secretion. Using an HTS approach, we have identified quinoline-based PDE-10A inhibitors as insulin secretagogues in vitro. Optimized compounds were evaluated in vivo where improvements in glucose tolerance and increases in insulin secretion were measured. 相似文献
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995.
Teepe AG Loprete DM He Z Hoggard TA Hill TW 《Fungal genetics and biology : FG & B》2007,44(6):554-562
The calC2 mutation in Aspergillus nidulans causes hypersensitivity to Calcofluor White, along with other drug sensitivities that indicate a defect in cell wall integrity. We have cloned CalC by complementation, isolating the A. nidulans orthologue of protein kinase C (PkcA). The pkcA allele of the calC2 strain contains a mutation predicted to introduce a charged arginine residue in place of neutral glycine at a conserved site located immediately beside the C1B regulatory domain. Both PkcA and calC2 map to the same region of chromosome VIII. A PkcA::GFP chimera localizes to hyphal apices and growing septa, as well as to the conidiogenous apices of phialides, indicating a role for PkcA in polarized cell wall growth. These observations support the hypothesis that the role of PkcA in A. nidulans, is comparable to that played by Pkc1p in the Saccharomyces cerevisiae cell wall integrity pathway. 相似文献
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997.
Revell TK Dunbar SG 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》2007,148(2):393-398
One of the proposed ecological functions of sleep is to conserve energy. The majority of studies that support this theory have been done on endothermic animals whose body temperatures drop during sleep due to the reduced neurological control of thermoregulation. In the present study, we examined typical temperatures to which the Desert Iguana, Dipsosaurus dorsalis, is exposed to in the field and found that mean high temperatures ranged from 24-58 degrees C throughout the active portion of the year. We also examined the ecological savings that sleep could provide for this ectothermic iguana using a closed system respirometer. We found that laboratory-acclimated iguanas are able to save significantly more (27.6%) energy by sleeping than by being awake and that field iguanas also had significant savings of energy (69.1%) while asleep. However, iguanas could save more energy by remaining awake at cooler temperatures than by sleeping at warmer temperatures. In addition, we found no correlation for time of night with metabolic rate. Our study supports the hypothesis that one potential function of sleep is to conserve energy. 相似文献
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