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11.
I. A. Tikhomirova S. G. Mikhailova S. V. Lychenko A. O. Oslyakova 《Human physiology》2012,38(1):56-62
The microcirculation state was assessed in the group of patients with ischemic stroke (n = 30) and the control group of healthy individuals (n = 27) using laser Doppler flowmetry and the wavelet analysis of the amplitude-frequency range of microvascular blood flow
oscillations combined with absorption spectroscopy. The hemorheological parameters (blood and plasma viscosity, the degree
of red blood cell aggregability and deformability) were assessed in both groups, as were their correlations with the microcirculation
parameters. Decreased tissue perfusion (by 25%) and specific oxygen consumption (by 21%) were revealed in a cerebrovascular
accident. Changes in the tone-forming regulatory mechanisms of microcirculation of vasodilating nature (decreased microvascular
tone, activation of the secretory function of endothelium) may be regarded as a compensatory reaction aimed at maintaining
the blood supply of organs and tissues in stroke. The blood viscosity increase in patients due to the plasma viscosity increase
and increased red blood cell aggregability and their decreased deformability cause the blood flow to slow down and the wall
shear stress to increase, which activates the endothelial secretory function and vasodilation of microvessels. Correlation
between the rheological parameters and the passive (respiratory and cardiac) rhythm amplitudes was observed in the control
group. In patients, the hemorheological parameters were correlated with the characteristics of the active factors of microvascular
blood flow modulation (endothelial, neurogenic, and myogenic), which confirms the role of changed blood properties and regulatory
tone-forming mechanisms in the maintenance of tissue perfusion in cerbrovascular accidents. 相似文献
12.
13.
I. A. Tikhomirova A. V. Murav’ev L. A. Mikhailichenko E. V. Golubkova 《Human physiology》2006,32(6):748-749
The extent of aggregation, electrophoretic mobility, and zeta potential of human erythrocytes were measured in the presence of some hormones and prostaglandins. Catecholamines, adrenomimetics, and prostaglandins were found to significantly increase the extent of aggregation; the electrophysiological characteristics of the cells were affected in different ways. 相似文献
14.
In the experiments with a heat-resistant line of Drosophila melanogaster, it has been shown that organismal heat-resistance is formed during ontogenesis, prior to hatching, though it can be changed, in accordance with the temperature conditions after hatching (acclimation). Heat-resistance of germ cells is formed during the pupal stage; it depends on the development temperature and remains unchanged thereafter. The mutation rate (the frequency of dominant lethals) in oocytes depends on the development temperature and not on the temperature life conditions of imago. Therefore, it may be concluded that heat-resistance of germ cells as well as their reaction on extreme temperatures are autonomous, meaning their independence of this property in the organism. 相似文献
15.
A new procedure for the isolation of homogeneous transketolase from baker's yeast based on the use of enzyme-specific antibodies immobilized on a insoluble matrix has been developed. The enzyme yield is 90% of its total content in the original yeast extract. The eluate from the immunocolumn was found to contain a previously unknown form of transketolase which represents an enzyme-RNA complex. 相似文献
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17.
A. V. Muravyov I. A. Tikhomirova E. P. Petrochenko N. V. Kislov Ju. V. Malysheva 《Biochemistry (Moscow) Supplemental Series A: Membrane and Cell Biology》2017,11(1):62-67
The relationships between the red blood cell (RBC) membrane elasticity and RBC aggregation in healthy individuals and in patients with anemia of malignant tumors treated with human erythropoietin drug epoetin alfa (EA) were analyzed. It was found that prior to the treatment of patients, incubation of RBCs with EA was accompanied by an increase of RBC deformability and the reduction of their aggregation (RBCA). In these circumstances the two characteristics of the RBC microrheology correlated negatively with each other (r =–0.734, p < 0.05). In contrast, aggregation and deformability of RBCs from healthy individuals increased under the influence of EA and positively correlated with each other (r = 0.580, p < 0.05). After a 4-week treatment of patients with EA, aggregation response of the patients’ RBCs was increased by 29% (p < 0.05) and was close to that of healthy RBCs. This change of the RBC aggregation response may be connected with an alteration of the sensitivity of the membrane cationic channel to EA and an increase of the cell deformability. This possibility was supported by experiments with the use of Ca2+-channel blocker verapamil and Ca2+-chelating agent EDTA. Under these conditions a decrease of the RBC aggregation varied from 40 to 50% (p < 0.05). It was suggested that the effectors of calcium regulatory cascade upon exposure to EA may be membrane integrin receptors of type IIb–IIIa. This assumption was confirmed by experiments employing the inhibitors of these receptors (tirofibam and integrelin) and a preparation of monoclonal antibodies against IIb–IIIa receptors (monafram), which produced a significant decrease (20–30%, p < 0.05) of the RBC aggregation. Thus, our findings suggest that the altered aggregation response of RBCs in anemic patients with malignant tumors can be restored by the correction of anemia with epoetin alfa. 相似文献
18.
N. A. Tikhomirova S. A. Ushakova G. S. Kalacheva 《Russian Journal of Plant Physiology》2009,56(1):22-28
Plant productivity of a common glasswort Salicornia europaea L. was investigated in relation to the type of nitrogen nutrition and as a function of macronutrient concentrations mimicking the mineral composition of human urine. The source of nutrient nitrogen had no substantial effect on productivity of Salicornia europaea. In plants grown on media with amide as a nitrogen source, the content of nitrogenous substances, including glutamic and aspartic amino acids, was higher than in plants grown with nitrate. In plants grown on media with mineral composition analogous to that of human urine, the shoots accumulated Na and K in almost equally high amounts, on the background of high and nearly equal Na and K concentrations in the nutrient media. 相似文献
19.
M. L. Oparin I. A. Kondratenkov O. S. Oparina A. B. Mamayev E. I. Tikhomirova 《Biology Bulletin》2017,44(10):1289-1294
This paper examines the influence of the location of settlements, railroads, and highways on the spatial structure of the Otis tarda population in the Trans-Volga region that was studied in the years 1998–2016 in a model area of 12000 km2 that is located in the southern part of the Saratov Trans-Volga region. The zone of the impact made by our estimated disturbance factor due to the movement of people and a variety of ground vehicles along various-purpose roads on the territorial distribution of bustards in autumn can be denoted as a 300–500 m width band on both sides of the transport communications. Shelterbelts that were created along transport communications render a beneficial effect on the distribution of O. tarda and reduce the influence of the disturbance factor. Furthermore, crop rotation fields with side sizes of more than 1 km can be considered a factor that compensates for the anxiety of birds. We have found that in the Saratov Trans-Volga region, because of the large size of crop rotation fields and significant development of roadside and shelter belts, no special measures are required to protect O. tarda such as restrictions on the movement of people and vehicles over the territory where this species lives. 相似文献
20.
S. V. Boronnikova Z. G. Kokaeva S. A. Gostimsky O. P. Dribnokhodova N. N. Tikhomirova 《Russian Journal of Genetics》2007,43(5):530-535
Genetic polymorphism of the Uralian relict plant species, large-flowered foxglove Digitalis grandiflora Mill. (family Scrophulariaceae), was examined using RAPD and ISSR techniques. A total of 149 RAPD and 74ISSR markers were tested. The indices characterizing polymorphism and genetic diversity were calculated. The data obtained pointed to a high level of genetic variation of D. grandiflora (P 95 = 65%). The cenopopulation examined was weakly differentiated with most of genetic diversity accounted by within-population differentiation. 相似文献