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931.
Mohammad Fathalipour Masoomeh Eghtedari Fernanda Borges Tiago Silva Fatemeh Moosavi Omidreza Firuzi Hossein Mirkhani 《化学与生物多样性》2019,16(12)
The purpose of this study was to examine the neuroprotective effects of caffeic acid hexyl ( CAF6 ) and dodecyl ( CAF12 ) amide derivatives on the early stage of retinopathy in streptozotocin‐induced diabetic rats. Animals were divided in five groups (n=8/group); one group consisted of non‐diabetic rats as control, while the other four were diabetic animals either non‐treated or treated with CAF6 , CAF12 or resveratrol intravitreally for four weeks. Retinal superoxide dismutase (SOD) activity and 8‐iso‐prostaglandin F2α (iPF2α) levels were evaluated by an ELISA assay. Phosphorylation of ERK1/2 and AKT was determined by immunoblotting in retinal homogenates. Retinal morphology was also examined using light microscopy. Treatment with CAF6 and CAF12 increased retinal SOD activity, while it decreased iPF2α levels in diabetic rats. Phosphorylation of ERK1/2 was increased, while AKT phosphorylation was decreased in diabetic rats compared to normal control and these alterations were significantly reversed in diabetic rats treated with CAF6 and CAF12 . Furthermore, thickness of the whole retinal layer, outer nuclear layer, and ganglion cell count were decreased in diabetic rats compared to control and CAF6 and CAF12 treatments prevented these changes. CAF6 and CAF12 seem to be effective agents for treatment of diabetic retinopathy via attenuation of retinal oxidative stress and improvement of neuronal survival signaling. 相似文献
932.
Mychel Raony Paiva Teixeira Morais Tiago da Silva Teófilo Bruna K. G. Azevedo Diogo Manuel Lopes Paiva Cavalcanti José Domingues Fontenele-Neto 《Journal of morphology》2019,280(7):968-981
Previous studies have suggested that the smooth-billed ani (Crotophaga ani, Linnaeus, 1758) breeds opportunistically following unpredictable rainfall in drought areas. To obtain proof of this phenomenon, the present study described and compared reproductive morphology and cell proliferation in the gonads of free-living smooth-billed anis during a wet season (April to June 2012) and the following dry season (July to September 2012) in a semiarid area using light and electron microscopy (transmission and scanning) and the AgNOR method. The morphological findings indicated distinct levels of reproductive activity related to seasonal changes. Morphological and morphometric analyses of the gonads confirmed intense gametogenic activity during the wet season, whereas gonadal involution occurred after rainfall ceased. The sizes of the testes and ovaries were significantly reduced compared to those in the wet season. The volumetric fraction of the seminiferous tubules in the testis decreased considerably, and no preovulatory follicles were detected in the ovary in the dry season. Moreover, the AgNOR count in the gonads revealed a significant decline in cell recruitment for gametogenesis after rainfall ceased. The histological findings indicated partial gonadal activation throughout the dry season. The analysis of the seminiferous epithelium confirmed the early testicular recrudescence phase, and sporadic postovulatory follicles indicated random ovulation during this time. The excurrent ducts and the oviduct also underwent remarkable involution in the dry season. Taken together, these findings confirm opportunistic breeding by smooth-billed anis in a semiarid habitat and suggest that gonadal recrudescence has been established as a reproductive strategy to cope with unexpected precipitation events. 相似文献
933.
934.
Tiago Buckup 《Archives of biochemistry and biophysics》2009,483(2):219-8337
Pump-degenerate four wave mixing (Pump-DFWM) is used for investigating the vibrational dynamics in the excited state of β-carotene in solution. In this 2D technique, an initial pump pulse promotes the system to the excited state, which is then probed by the succeeding DFWM sequence. We focus particularly on the internal conversion between the S2 and S1 state with high temporal and spectral resolution. The frequency shift of the excited state vibrations is measured and is explained as mode-specific vibrational cooling. Our results suggest an internal conversion in a time range between 260 and 500 fs without any intermediate states. 相似文献
935.
Pablo A. P. Antiqueira Paula M. de Omena Thiago Gonalves-Souza Camila Vieira Gustavo H. Migliorini Mnica F. Kersch-Becker Tiago N. Bernab Ftima C. Recalde Sandra Benavides- Gordillo Gustavo Q. Romero 《Oecologia》2020,192(3):745-753
Biotic and abiotic factors may individually or interactively disrupt plant–pollinator interactions, influencing plant fitness. Although variations in temperature and precipitation are expected to modify the overall impact of predators on plant–pollinator interactions, few empirical studies have assessed if these weather conditions influence anti-predator behaviors and how this context-dependent response may cascade down to plant fitness. To answer this question, we manipulated predation risk (using artificial spiders) in different years to investigate how natural variation in temperature and precipitation may affect diversity (richness and composition) and behavioral (visitation) responses of flower-visiting insects to predation risk, and how these effects influence plant fitness. Our findings indicate that predation risk and an increase in precipitation independently reduced plant fitness (i.e., seed set) by decreasing flower visitation. Predation risk reduced pollinator visitation and richness, and altered species composition of pollinators. Additionally, an increase in precipitation was associated with lower flower visitation and pollinator richness but did not alter pollinator species composition. However, maximum daily temperature did not affect any component of the pollinator assemblage or plant fitness. Our results indicate that biotic and abiotic drivers have different impacts on pollinator behavior and diversity with consequences for plant fitness components. Even small variation in precipitation conditions promotes complex and substantial cascading effects on plants by affecting both pollinator communities and the outcome of plant–pollinator interactions. Tropical communities are expected to be highly susceptible to climatic changes, and these changes may have drastic consequences for biotic interactions in the tropics. 相似文献
936.
Kelsey D. McDermott M. Agustina Frechou Jake T. Jordan Sunaina S. Martin J. Tiago Gonçalves 《Aging cell》2023,22(9):e13924
Aging is associated with cognitive deficits, with spatial memory being very susceptible to decline. The hippocampal dentate gyrus (DG) is important for processing spatial information in the brain and is particularly vulnerable to aging, yet its sparse activity has led to difficulties in assessing changes in this area. Using in vivo two-photon calcium imaging, we compared DG neuronal activity and representations of space in young and aged mice walking on an unfamiliar treadmill. We found that calcium activity was significantly higher and less tuned to location in aged mice, resulting in decreased spatial information encoded in the DG. However, with repeated exposure to the same treadmill, both spatial tuning and information levels in aged mice became similar to young mice, while activity remained elevated. Our results show that spatial representations of novel environments are impaired in the aged hippocampus and gradually improve with increased familiarity. Moreover, while the aged DG is hyperexcitable, this does not disrupt neural representations of familiar environments. 相似文献
937.
938.
International Journal of Primatology - Vertebrate predation was a vital behavior during human evolution. Some Afro-Eurasian primates, such as baboons (Papio spp.) and chimpanzees (Pan troglodytes),... 相似文献
939.
Abstract. The common waxbill Estrilda astrild was first introduced to Portugal from Africa in 1964, and has spread across much of the country and into Spain. We modelled the expansion of the common waxbill on a 20 × 20 km UTM grid in 4‐year periods from 1964 to 1999. The time variation of the square root of the occupied area shows that this expansion process is stabilizing in Portugal, and reasons for this are discussed. Several methods used to model biological expansions are not appropriate for the present case, because little quantitative data are available on the species ecology and because this expansion has been spatially heterogeneous. Instead, colonization on a grid was modelled as a function of several biophysical and spatio‐temporal variables through the fitting of a multivariate autologistic equation. This approach allows examination of the underlying factors affecting the colonization process. In the case of the common waxbill it was associated positively with its occurrence in adjacent cells, and affected negatively by altitude and higher levels of solar radiation. 相似文献
940.
Xiang Ji Tiago Ferreira Beth Friedman Rui Liu Hannah Liechty Erhan Bas Jayaram Chandrashekar David Kleinfeld 《Neuron》2021,109(7):1168-1187.e13
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