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71.
72.
Ana P Teixeira Carlos Alves Paula M Alves Manuel JT Carrondo Rui Oliveira 《BMC bioinformatics》2007,8(1):30
Background
The progress in the "-omic" sciences has allowed a deeper knowledge on many biological systems with industrial interest. This knowledge is still rarely used for advanced bioprocess monitoring and control at the bioreactor level. In this work, a bioprocess control method is presented, which is designed on the basis of the metabolic network of the organism under consideration. The bioprocess dynamics are formulated using hybrid rigorous/data driven systems and its inherent structure is defined by the metabolism elementary modes. 相似文献73.
Carmen Lai Hugo M Horlings Marc J van de Vijver Eric H van Beers Petra M Nederlof Lodewyk FA Wessels Marcel JT Reinders 《BMC bioinformatics》2007,8(1):422
Background
Array comparative genome hybridization (aCGH) provides information about genomic aberrations. Alterations in the DNA copy number may cause the cell to malfunction, leading to cancer. Therefore, the identification of DNA amplifications or deletions across tumors may reveal key genes involved in cancer and improve our understanding of the underlying biological processes associated with the disease. 相似文献74.
75.
The mechanisms responsible for the resistance to the anabolic actions of IGF-I induced by zinc deficiency are not understood. We showed that zinc chelation by DTPA (diethylenetriaminepenta-acetic acid) inhibits [3H]thymidine incorporation stimulated by IGF-I in Rat-1 fibroblasts. This inhibition was specific of zinc chelation since it was prevented by the addition of zinc to DTPA. The stimulation of MAPK, which is crucial for the [3H]thymidine incorporation induced by IGF-I in Rat-1 cells, was partially blunted by DTPA. Therefore, the inhibition of the mitogenic action of IGF-I in Rat-1 fibroblasts by DTPA is potentially caused by decreased MAPK activation by IGF-I. 相似文献
76.
77.
Schwaiger FW; Weyers E; Buitkamp J; Ede AJ; Crawford A; Epplen JT 《Molecular biology and evolution》1994,11(2):239-249
Exon 2 sequences of an expressed MHC-DRB locus from sheep were examined for
polymorphisms in both the antigen-binding regions and the adjacent intronic
mixed simple tandem repeat. Twenty-one novel exon 2 Ovar-DRB alleles were
identified. Short nucleotide motifs are extensively shared between certain
exon 2 regions of Ovar-DRB alleles. The simple repeat variations, the
number of different amino acids at usually polymorphic sites, and the
number of silent substitutions were reduced in the intraspecies analyses of
sheep DRB sequences, compared with those of cattle and goats. It was
paradoxical that the abundance of different sheep alleles was similar to
that of cattle and goats. This paradox may be explained by postulating a
relatively small number of "ancient" alleles, with the present-day Ovar-DRB
alleles being generated by reciprocal exchange of nucleotide motifs. At the
antigen-binding sites, new combinations of amino acids were maintained in
Ovar-DRB alleles by strong positive selection. In sheep--and less
pronounced in goats and cattle--the DRB alleles can be divided into two
groups. In one group, silent substitutions are increased when compared with
the other. This suggests separate evolutionary pathways for certain groups
of DRB alleles within a species. The simple repetitive sequences are also
discussed with respect to the evolution of DRB alleles.
相似文献
78.
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Bindels LB Beck R Schakman O Martin JC De Backer F Sohet FM Dewulf EM Pachikian BD Neyrinck AM Thissen JP Verrax J Calderon PB Pot B Grangette C Cani PD Scott KP Delzenne NM 《PloS one》2012,7(6):e37971
The gut microbiota has recently been proposed as a novel component in the regulation of host homeostasis and immunity. We have assessed for the first time the role of the gut microbiota in a mouse model of leukemia (transplantation of BaF3 cells containing ectopic expression of Bcr-Abl), characterized at the final stage by a loss of fat mass, muscle atrophy, anorexia and inflammation. The gut microbial 16S rDNA analysis, using PCR-Denaturating Gradient Gel Electrophoresis and quantitative PCR, reveals a dysbiosis and a selective modulation of Lactobacillus spp. (decrease of L. reuteri and L. johnsonii/gasseri in favor of L. murinus/animalis) in the BaF3 mice compared to the controls. The restoration of Lactobacillus species by oral supplementation with L. reuteri 100-23 and L. gasseri 311476 reduced the expression of atrophy markers (Atrogin-1, MuRF1, LC3, Cathepsin L) in the gastrocnemius and in the tibialis, a phenomenon correlated with a decrease of inflammatory cytokines (interleukin-6, monocyte chemoattractant protein-1, interleukin-4, granulocyte colony-stimulating factor, quantified by multiplex immuno-assay). These positive effects are strain- and/or species-specific since L. acidophilus NCFM supplementation does not impact on muscle atrophy markers and systemic inflammation. Altogether, these results suggest that the gut microbiota could constitute a novel therapeutic target in the management of leukemia-associated inflammation and related disorders in the muscle. 相似文献