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31.
On the occasion of the first international workshop on systems radiation biology we review the role of cell renewal systems
in maintaining the integrity of the mammalian organism after irradiation. First, 11 radiation emergencies characterized by
chronic or protracted exposure of the human beings to ionizing irradiation were “revisited”. The data provide evidence to
suggest that at a daily exposure of about 10–100 mSv, humans are capable of coping with the excess cell loss for weeks or
even many months without hematopoietic organ failure. Below 10 mSv/day, the organisms show some cellular or subcellular indicators
of response. At dose rates above 100 mSv/day, a progressive shortening of the life span of the irradiated organism is observed.
To elucidate the mechanisms relevant to tolerance or failure, the Megakaryocyte–thrombocyte cell renewal system was investigated.
A biomathematical model of this system was developed to simulate the development of thrombocyte concentration as a function
of time after onset of chronic radiation exposure. The hematological data were taken from experimental chronic irradiation
studies with dogs at the Argonne National Laboratory, USA. The results of thrombocyte response patterns are compatible with
the notion of an “excess cell loss” (compared to the steady-state) in all proliferative cell compartments, including the stem
cell pool. The “excess cell loss” is a function of the daily irradiation dose rate. Once the stem cell pool is approaching
an exhaustion level, a “turbulence region” is reached. Then it takes a very little additional stress for the system to fail.
We conclude that in mammalian radiation biology (including radiation medicine), it is important to understand the physiology
and pathophysiology of cell renewal systems in order to allow predicting the development of radiation induced lesions. 相似文献
32.
Deciduous lower premolars (milk teeth) of the Eocene artiodactyl family Cebochoeridae possess accessory denticles and are
remarkably similar to both deciduous and adult teeth of the cetacean family Basilosauridae, suggesting that morphological
characters of juvenile dentitions are important to understanding the phylogenetic origin of whales and morphological transitions
in the cetartiodactyl lineage. Incorporation of these new characters into a larger phylogenetic analysis of morphological
characters of artiodactyls, mesonychids, and basal and recent whales supports a monophyletic Cetartiodactyla, but does not
directly support a whale–hippo relationship. However, the presence of accessory denticles on some artiodactyl dentitions weakens
the morphological support for a monophyletic Artiodactyla, suggesting either that whales and cebochoerids may be more closely
related than had been thought, or that cebochoerids share a developmental pathway with cetaceans. 相似文献
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37.
Theodor Frhr. v. Brand 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1928,8(3-4):613-624
Zusammenfassung Der Ätherextrakt von Fasciola hepatica setzt sich nach meinen Untersuchungen folgendermaßen zusammen (in abgerundeten Prozentzahlen: Lecithin und andere Phosphatide. 30% Gesättigte Fettsäuren als Glyzeride vorliegend. 4,, Ungesättigte Fettsäuren als Glyzeride vorliegend' 12,, Glyzerin 2,, Cholesterin. 19,, Fettsäuren in Seifenform vorliegend 15,, Asche aus der Seife 1,, Nicht näher charakterisierte Lipoide. 17 相似文献
38.
Markus Wilmsen Michaela Berensmeier Franz Theodor Fürsich Mahmoud Reza Majidifard Felix Schlagintweit 《Facies》2018,64(2):11
An integrated study of the litho-, bio-, and microfacies of several sections has greatly improved the knowledge on the stratigraphy and depositional setting of the Coniacian to Campanian Haftoman Formation in the Khur area of the northern Yazd Block, Central Iran. Generally, the Haftoman Formation rests on a major tectonic unconformity and commences with a basal conglomerate followed by up to 900 m of shallow-water carbonates with local red sandstone intercalations. Five different depositional environments (from distal to proximal) characterize the facies associations (FA) of the Haftoman Formation: silty, spiculitic wackestone (proximal basin, FA I), bio-/intraclastic wacke-, pack-, and grainstone (marginal shoals, FA II), bioclastic rud-/float-/boundstone (outer platform, FA III), silty mud-/wackestone (lagoonal inner platform, FA IV), and sandstone/sandy limestone (areas close to the mouth of ephemeral streams, FA V). The litho-, micro-, and biofacies of the Haftoman Formation are typical for an epeiric carbonate platform characterized by an arid climate and lagoonal circulation, resulting in nutrient-poor waters, warm temperatures, and high salinities. The Haftoman Platform was attached to an emergent arid hinterland formed by the Anarak Metamorphic Complex to the west and southwest of the study area. Unconformity-bounded depositional units indicate sea-level changes that may correspond to 400-kyr high-frequency sequences but further studies are needed to fully exploit the potential of sequence stratigraphy for regional and inter-regional correlation of the Haftoman Formation. 相似文献
39.
Arista Fourie Michael J. Wingfield Brenda D. Wingfield Magriet A. van der Nest M. Theodor Loots Irene Barnes 《Fungal biology》2018,122(7):717-729
Ceratocystis fimbriata is a fungal plant pathogen that causes black rot on Ipomoea batatas. Based on inoculation studies on numerous tree species, the pathogen is known to be host specific. The closely related species, Ceratocystis manginecans, causes severe wilt on a broad range of tree hosts, including Mangifera indica, Acacia mangium and other leguminous tree species. The genetic factors underlying the pathogenicity and host specificity of Ceratocystis species have rarely been investigated. In this study, an F1 population of 70 recombinant progeny from a cross between C. fimbriata and C. manginecans was generated and the inheritance of various phenotypic traits was investigated. Results showed that colony colour, growth rate, asexual spore production and aggressiveness to I. batatas and A. mangium are all quantitative traits with high levels of heritability. However, conidia production and aggressiveness appeared to be regulated by a small number of genes. No correlation could be found between aggressiveness and other phenotypic traits, suggesting that these are inherited independently. This is the first study to consider genetic inheritance of pathogenicity and host specificity in Ceratocystis species and the results will contribute, in future, to the identification of quantitative trait loci and candidate genes associated with the traits investigated. 相似文献
40.
Control of plastid division by means of nuclear DNA amount 总被引:2,自引:0,他引:2
Theodor Butterfass 《Protoplasma》1973,76(2):167-195
Summary For a given cell type and genotype a close positive correlation exists between the number of plastids in a cell and the amount of DNA in the nucleus. Comprehensive evidence is presented. The duplication of the DNA amount entails an increase of the plastid number in differentiating cells by about 70%. Exceptions reported in the literature are critically examined. The odds are in favour of the assumption that exceptions to the rule which are not due to special circumstances do not exist. In meristematic cells even a duplication of the plastid number will occur, for cells without plastids are not to be found. The plastids are always ready to divide, the interpretation goes, but the size of their populations is limited by the amount of nuclear DNA. Thus meristematic cells manage to control their plastid populations by releasing once in a cell cycle the brakes imposed upon plastid division, whereupon the plastids make use of their newly won freedom, dividing until the old ratio between plastid number and nuclear DNA amount is established again. As a shorter time is needed for plastid division than for mitosis, there is no danger of cells arising without plastids; no distributing mechanism is required if at least three to four plastids are present in a cell. The findings are consistent with and would appear to be best explained by the theory of the symbiotic origin of the plastids. 相似文献