全文获取类型
收费全文 | 173篇 |
免费 | 6篇 |
专业分类
179篇 |
出版年
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2016年 | 3篇 |
2015年 | 5篇 |
2014年 | 12篇 |
2013年 | 2篇 |
2012年 | 8篇 |
2011年 | 11篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 14篇 |
2007年 | 4篇 |
2006年 | 6篇 |
2005年 | 5篇 |
2004年 | 5篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2001年 | 7篇 |
2000年 | 8篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1994年 | 3篇 |
1983年 | 2篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1974年 | 2篇 |
1967年 | 1篇 |
1966年 | 3篇 |
1965年 | 2篇 |
1964年 | 1篇 |
1960年 | 2篇 |
1959年 | 2篇 |
1954年 | 1篇 |
1953年 | 1篇 |
1952年 | 1篇 |
1950年 | 1篇 |
1948年 | 1篇 |
1936年 | 2篇 |
1934年 | 2篇 |
1933年 | 2篇 |
1930年 | 1篇 |
1928年 | 1篇 |
1920年 | 1篇 |
1912年 | 1篇 |
1904年 | 1篇 |
1901年 | 2篇 |
排序方式: 共有179条查询结果,搜索用时 15 毫秒
161.
Waschinski CJ Barnert S Theobald A Schubert R Kleinschmidt F Hoffmann A Saalwächter K Tiller JC 《Biomacromolecules》2008,9(7):1764-1771
The antimicrobial activity of poly(2-methyl-1,3-oxazoline)s (PMOX) with the antimicrobial N,N-dimethyldodecylammonium (DDA) end group is greatly dependent on the nature of the group at the distal end of the polymer, the satellite group. Three comparable PMOX with a DDA end group and different satellite groups (methyl, decyl, hexadecyl) were investigated with respect to the reasons for the huge differences in their biocidal behavior. Static light scattering (SLS) and pulsed field gradient diffusion NMR measurements revealed that the samples show comparable aggregation conduct, thus, not being responsible for the varying biological activity. Experiments using different liposomal systems as models for bacterial cell membranes have been performed. It was found that differential interactions between the respective polymers and the phospholipid membranes constitute the reason for the varying effectiveness observed in antimicrobial susceptibility determinations. 相似文献
162.
Economic improvement of the fermentative production of gallidermin by Staphylococcus gallinarum 总被引:1,自引:0,他引:1
Gallidermin production by Staphylococcus gallinarum was optimal using a new developed medium consisting of 50 g yeast extract l–1, 45 g CaCl2 l–1 and 5 g maltose l–1. Medium optimisation led to the cost of the medium decreasing by 93% compared to the previously used medium and in addition gained a higher product yield. A scale-up of the process based on the new medium was successfully tested up to a working volume of 200 l. 相似文献
163.
Boyd HF Fell SC Flynn ST Hickey DM Ife RJ Leach CA Macphee CH Milliner KJ Moores KE Pinto IL Porter RA Rawlings DA Smith SA Stansfield IG Tew DG Theobald CJ Whittaker CM 《Bioorganic & medicinal chemistry letters》2000,10(22):2557-2561
From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human lipoprotein-associated phospholipase A2. These compounds show greatly enhanced activity in isolated plasma. Selected derivatives such as compounds 51 and 52 are orally active with a good duration of action. 相似文献
164.
165.
G. W. Theobald 《BMJ (Clinical research ed.)》1965,2(5457):330-333
166.
167.
168.
Douglas L Theobald 《Biology direct》2011,6(1):1-25
Life is a chemical reaction. Three major transitions in early evolution are considered without recourse to a tree of life. The origin of prokaryotes required a steady supply of energy and electrons, probably in the form of molecular hydrogen stemming from serpentinization. Microbial genome evolution is not a treelike process because of lateral gene transfer and the endosymbiotic origins of organelles. The lack of true intermediates in the prokaryote-to-eukaryote transition has a bioenergetic cause. This article was reviewed by Dan Graur, W. Ford Doolittle, Eugene V. Koonin and Christophe Malaterre. 相似文献
169.
170.
The correlation between the consumption of amino acids and the production of the polypeptide antibiotic gallidermin by Staphylococcus gallinarum Tü 3928 was investigated by on-line determination of amino acids and pulse experiments. A prolonged production phase together with an increase in gallidermin formation of about 25% was obtained during pulse and fed-batch experiments with the amino acids glutamic acid, glycine, serine and threonine. 相似文献