全文获取类型
收费全文 | 36篇 |
免费 | 10篇 |
国内免费 | 1篇 |
专业分类
47篇 |
出版年
2021年 | 2篇 |
2020年 | 1篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 1篇 |
2013年 | 2篇 |
2012年 | 4篇 |
2011年 | 2篇 |
2010年 | 1篇 |
2006年 | 2篇 |
2005年 | 2篇 |
2003年 | 2篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1992年 | 1篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有47条查询结果,搜索用时 0 毫秒
11.
12.
The migratory and stationary ecotypes of Atlantic cod are two ecological forms that differ by migratory behavior. Recent studies have revealed extended genomic regions associated with local adaptations of the ecotypes. In this study, a panel of markers was created to identify the variants of these genomic regions. 相似文献
13.
V. I. Teterina L. V. Sukhanova B. E. Bogdanov P. N. Anoshko S. V. Kirilchik 《Russian Journal of Genetics》2005,41(7):750-754
Intraspecific genetic polymorphism of a Baikal Lake endemic, little Baikal oilfish (Comephorus dybowski Korotneff, 1905), was evaluated based on microsatellite analysis. Six microsatellite loci designed for the European sculpin, Cottus gobio, were used. Each locus was tested using 25 to 32 individuals from each of the Baikal basins (southern, middle, and northern). Analysis of genetic differentiation (F
ST and R
ST) revealed no statistical significant differences between the samples. The data showed that the target species was represented by a single panmictic stable population.__________Translated from Genetika, Vol. 41, No. 7, 2005, pp. 919–924.Original Russian Text Copyright © 2005 by Teterina, Sukhanova, Bogdanov, Anoshko, Kirilchik. 相似文献
14.
15.
Formation of the poliovirus replication complex requires coupled viral translation, vesicle production, and viral RNA synthesis 下载免费PDF全文
Poliovirus (PV) infection induces the rearrangement of intracellular membranes into characteristic vesicles which assemble into an RNA replication complex. To investigate this transformation, endoplasmic reticulum (ER) membranes in HeLa cells were modified by the expression of different cellular or viral membrane-binding proteins. The membrane-binding proteins induced two types of membrane alterations, i.e., extended membrane sheets and vesicles similar to those found during a PV infection. Cells expressing membrane-binding proteins were superinfected with PV and then analyzed for virus replication, location of membranes, viral protein, and RNA by immunofluorescence and fluorescent in situ hybridization. Cultures expressing cellular or viral membrane-binding proteins, but not those expressing soluble proteins, showed a markedly reduced ability to support PV replication as a consequence of the modification of ER membranes. The altered membranes, regardless of their morphology, were not used for the formation of viral replication complexes during a subsequent PV infection. Specifically, membrane sheets were not substrates for PV-induced vesicle formation, and, surprisingly, vesicles induced by and carrying one or all of the PV replication proteins did not contribute to replication complexes formed by the superinfecting PV. The formation of replication complexes required active viral RNA replication. The extensive alterations induced by membrane-binding proteins in the ER resulted in reduced viral protein synthesis, thus affecting the number of cells supporting PV multiplication. Our data suggest that a functional replication complex is formed in cis, in a coupled process involving viral translation, membrane modification and vesicle budding, and viral RNA synthesis. 相似文献
16.
OL Garibay-Cerdenares VI Hernández-Ramírez JC Osorio-Trujillo D Gallardo-Rincón P Talamás-Rohana 《Cell Adhesion & Migration》2015,9(5):394-405
Haptoglobin (Hp) is an acute-phase protein that is produced by the liver to capture the iron that is present in the blood circulation, thus avoiding its accumulation in the blood. Moreover, Hp has been detected in a wide variety of tissues, in which it performs various functions. In addition, this protein is considered a potential biomarker in many diseases, such as cancer, including ovarian carcinoma; however, its participation in the cancerous processes has not yet been determined. The objective of this work was to demonstrate the expression of Hp and its receptor CCR2 in the ovarian cancer cells and its possible involvement in the process of cell migration through changes in the rearrangement of the actin cytoskeleton using western blot and wound-healing assays and confirming by confocal microscopy. Ovarian cancer cells express both Hp and its receptor CCR2 but only after exposure to ascitic fluid, inducing moderated cell migration. However, when the cells are exposed to exogenous Hp, the expression of CCR2 is induced together with drastic changes in the actin cytoskeleton rearrangement. At the same time, Hp induced cell migration in a much more efficient manner than did ascitic fluid. These effects were blocked when the CCR2 synthetic antagonist RS102895 was used to pretreat the cells. These results suggest that Hp-induced changes in the cell morphology, actin cytoskeleton structure, and migration ability of tumor cells, is possibly “preparing” these cells for the potential induction of the metastatic phenotype. 相似文献
17.
18.
Chaprov K. D. Teterina E. V. Roman A. Yu. Ivanova T. A. Goloborshcheva V. V. Kucheryanu V. G. Morozov S. G. Lysikova E. A. Lytkina O. A. Koroleva I. V. Popova N. Ia. Antohin A. I. Ovchinnikov R. K. Kukharsky M. S. 《Molecular Biology》2021,55(1):133-142
Molecular Biology - Aggregated forms of α-synuclein are core components of pathohistological inclusions known as Lewy bodies in substantia nigra (SN) neurons of patients with Parkinson’s... 相似文献
19.
FRANCESC SARDÀ‐PALOMERA GERARD BOTA CARLOS VIÑOLO ORIOL PALLARÉS VÍCTOR SAZATORNIL LLUÍS BROTONS SPARTACUS GOMÁRIZ FRANCESC SARDÀ 《Ibis》2012,154(1):177-183
Unmanned aircraft systems (UAS) are remote‐controlled devices capable of collecting information from difficult‐to‐access places while minimizing disturbance. Although UAS are increasingly used in many research disciplines, their application to wildlife research remains to be explored in depth. Here, we report on the use of a small UAS to monitor temporal changes in breeding population size in a Black‐headed Gull Chroicocephalus ridibundus colony. This method makes it possible to obtain georeferenced data on nest locations without causing colony disturbance, which would not otherwise be possible via direct ground observations. 相似文献
20.
Courtney D. Fitzhugh Matthew M. Hsieh Darlene Allen Wynona A. Coles Cassie Seamon Michael Ring Xiongce Zhao Caterina P. Minniti Griffin P. Rodgers Alan N. Schechter John F. Tisdale James G. Taylor VI 《PloS one》2015,10(11)