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101.
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Background  

Main claims of the literature are that functional recovery of the paretic upper limb is mainly defined within the first month post stroke and that rehabilitation services should preferably be applied intensively and in a task-oriented way within this particular time window. EXplaining PLastICITy after stroke (acronym EXPLICIT-stroke) aims to explore the underlying mechanisms of post stroke upper limb recovery. Two randomized single blinded trials form the core of the programme, investigating the effects of early modified Constraint-Induced Movement Therapy (modified CIMT) and EMG-triggered Neuro-Muscular Stimulation (EMG-NMS) in patients with respectively a favourable or poor probability for recovery of dexterity.  相似文献   
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104.

Background  

Intoxication from the psychostimulant methamphetamine (METH) because of cardiovascular collapse is a common cause of death within the abuse population. For obvious reasons, the heart has been taken as the primary target for this METH-induced toxicity. The demonstration that failure of brain stem cardiovascular regulation, rather than the heart, holds the key to cardiovascular collapse induced by the pesticide mevinphos implicates another potential underlying mechanism. The present study evaluated the hypothesis that METH effects acute cardiovascular depression by dampening the functional integrity of baroreflex via an action on brain stem nuclei that are associated with this homeostatic mechanism.  相似文献   
105.
The differences in shell structure and population turnover between organic-poor, impunctate (Hemithiris) and organic-rich, punctate brachiopod (Terebratalia) in a mixed-bottom, siliciclastic setting (San Juan Islands, WA) lead to different taphonomic damage and fidelity with respect to community-level abundance in death assemblages. In comparing shell interiors of similar-sized specimens, Terebratalia is predominantly affected by fibre detachment and shows almost no microbioerosion at the SEM scale; whereas, Hemithiris shows less marked fibre detachment at the SEM scale and is more intensely affected by microbioerosion both at SEM and light microscope (LM) scales. Fibre detachment related to rapid, microbially-induced organic matter decay appears to be the main destructive process acting on Terebratalia. Higher bioerosion levels in Hemithiris at SEM and LM scales are probably related to a combination of a low maceration rate and a preferential settlement by borers. From their vastly different abundances in life assemblages it can be deduced that Terebratalia produces dead shells at a much higher rate than Hemithiris. Therefore, the proportion of altered Terebratalia, relative to Hemithiris, is expected to be decreased due to its higher production of recently dead cohorts. That Terebratalia is also characterized by high damage levels shows that differential population turnover alone is not responsible for the differences in taphonomic damage. This shows that organic-rich and organic-poor shells are characterized by differential post-mortem durability. Although very few Hemithiris are present in the life assemblages, high durability ensures its relative over-representation in death assemblages. Terebratalia is not strongly under-represented in death assemblages, despite its high destruction rate, because of large production of recently dead shells. Even with the biasing effect of differential durability, the good fidelity reported in previous live-dead studies can be enhanced by higher population turnover of numerically dominant taxa, leading to constant input of recently dead shells into death assemblages.  相似文献   
106.

Background  

Using a functional genomics approach we addressed the impact of folate overproduction on metabolite formation and gene expression in Lactobacillus plantarum WCFS1. We focused specifically on the mechanism that reduces growth rates in folate-overproducing cells.  相似文献   
107.
Spermatozoa of Bufo bufo japonicus were briefly treated with Triton X-100 to remove their plasma membrane, and were injected into oocytes at various stages of maturation division. All the sperm injected into mature coelomic eggs transformed into pronuclei and synthesized DNA, as a normally fertilizing sperm does. The sperm injected into oocytes at the germinal vesicle (GV) stage did not show any change as long as the GV remained intact. In the oocytes which were induced to mature by progesterone, the injected sperm displayed characteristic features in synchrony with those of the resident female nucleus. These included the formation of several sperm-derived chromosomes in association with multipolar spindles in the oocytes from the stage of the germinal vesicle breakdown to the first polar spindle; the appearance of swollen, vesicular nuclei without concomitant DNA synthesis in those at the stage of the first polar body emission; and the reappearance of the condensed chromosomes with giant spindles in those at the stage of the second meiotic metaphase. Pricking of these last oocytes induced the formation of several male pronuclei and DNA synthesis. These results prove that the injection of detergent-treated sperm employed here provides an excellent means of studying the cytoplasmic state that regulates nuclear behavior.  相似文献   
108.
To analyse the status and phylogeny of the genusPhyllocladus,seedsof all seven species of the genus were studied. The complexof features of thePhyllocladusreproductive system point to theisolated position of the genus within the conifers. Relationswith Podocarpaceae s. l., Taxaceae s. l. and Cephalotaxaceaeappeared to be remote because a complex of features clearlydistinguishesPhyllocladusfrom the afore-mentioned taxa. We findit advisable to circumscribe the family Phyllocladaceae as Bessey(1907) did, and place it into the order Taxales Knobl. in Warming(1890). From investigations of the seeds it appears the genusPhyllocladusconsistsof seven species, forming five groups. There is a significanttendency for transformation of the female reproductive structureswithin the generic boundaries ofPhyllocladus—seeds, originallysolitary, tending to aggregate in various kinds of compact clusters.Copyright1999 Annals of Botany Company PhyllocladusL. C. & A. Rich, ex Mirb., seed anatomy, seed morphology, systematics, phylogenetic relationships, Phyllocladaceae, Podocarpaceae s. str., Acmopyleaceae, Nageiaceae, Austrotaxaceae, Amentotaxaceae, Torreyaceae, Taxaceae, s. str., Cephalotaxaceae, Taxales.  相似文献   
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