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排序方式: 共有536条查询结果,搜索用时 15 毫秒
521.
A thorough review of the medical literature is made regarding Chagas' disease in Mexico and elsewhere since 1939, when Trypanosoma cruzi was first reported in this country, until 1991. The location where human cases, non human reservoirs and vectors have been found and are pointed out by means of tables and charts. Comments are made regarding the results reported. The importance of increasing the studies of Chagas' disease in Mexican Republic is stressed. 相似文献
522.
Le Duc Huy Ta Carina Jing Xuan Tay Christophe Lay Paola Florez de Sessions Cheryl Pei Ting Tan Michelle Jia Yu Tay Hui Xing Lau Atiqa Binte Zulkifli Gaik Chin Yap Elizabeth Huiwen Tham Eliza Xin Pei Ho Anne Eng Neo Goh Keith M Godfrey Johan G Eriksson Jan Knol Peter D Gluckman Yap Seng Chong Jerry Kok Yen Chan Kok Hian Tan Kok Wee Chong Si Hui Goh Zai Ru Cheng Bee Wah Lee Lynette Pei-chi Shek Evelyn Xiu Ling Loo 《Environmental microbiology》2021,23(12):7710-7722
Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S-PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human-associated bacteria Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium (Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human-associated bacteria (Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium). Exposure to natural environmental microbiota may be beneficial to modulate shed human-associated microbiota in an indoor environment. 相似文献
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S. K. Tay A. Singer J. F. A. Griffin D. G. Wickens T. L. Dormandy 《Free radical research》1987,3(1):27-31
The molar ratio between a diene-conjugated linoleic-acid isomer (18:2(9, 11)) and the parent linoleic acid (18:2(9, 12)), both esterified as phospholipids, was significantly different in exfoliated cells from normal cervices and from cervices with colposcopic and cytological evidence of precancer. The measurement may provide a simple and perhaps improved alternative to cytological screening. 相似文献
525.
Joachimsthal E.L. Ivanov V. Tay S.T.L. Tay J.H. 《World journal of microbiology & biotechnology》2003,19(5):527-533
The use of fluorescence in situ hybridization (FISH) in conjunction with flow cytometry is a popular method of analysing environmental microbial populations. However, false-positive results can be produced if the specificity of oligonucleotide probe binding is not considered. An aim of this research was to evaluate the specificity of labelled oligonucleotide probe binding in FISH by flow cytometry. An excess of unlabelled probe was used to competitively inhibit the specific binding of labelled probe. Comparisons were made between the mean cell fluorescence and the number of fluorescently stained cells in a pure culture of Escherichia coli ATCC 53323. Specific binding of species-specific probes for the detection of E. coli was in the range 47–70% of total binding. A eukaryote probe and a nonsense probe, used as negative controls, had no specific binding with cells of E. coli. The significance of the results obtained is that the enumeration of specifically probe-bound microbial cells by FISH and flow cytometry must be made by an application of labelled and unlabelled probes to distinguish specifically stained cells. This is also a more practical method for the analysis of environmental samples compared to washing of excess non-specifically bound probe, due to the reduction of cell loss from the analysis. 相似文献
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Jian‐fei Yan Wen‐pin Qin Bo‐cheng Xiao Qian‐qian Wan Franklin R. Tay Li‐na Niu Kai Jiao 《Biological reviews of the Cambridge Philosophical Society》2020,95(4):960-985
In the progression of osteoarthritis, pathological calcification in the affected joint is an important feature. The role of these crystallites in the pathogenesis and progression of osteoarthritis is controversial; it remains unclear whether they act as a disease initiator or are present as a result of joint damage. Recent studies reported that the molecular mechanisms regulating physiological calcification of skeletal tissues are similar to those regulating pathological or ectopic calcification of soft tissues. Pathological calcification takes place when the equilibrium is disrupted. Calcium phosphate crystallites are identified in most affected joints and the presence of these crystallites is closely correlated with the extent of joint destruction. These observations suggest that pathological calcification is most likely to be a disease initiator instead of an outcome of osteoarthritis progression. Inhibiting pathological crystallite deposition within joint tissues therefore represents a potential therapeutic target in the management of osteoarthritis. 相似文献
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