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71.
Wright ND Bahrami B Johnson E Di Malta G Rees G Frith CD Dolan RJ 《Proceedings. Biological sciences / The Royal Society》2012,279(1736):2275-2280
Collaboration can provide benefits to the individual and the group across a variety of contexts. Even in simple perceptual tasks, the aggregation of individuals' personal information can enable enhanced group decision-making. However, in certain circumstances such collaboration can worsen performance, or even expose an individual to exploitation in economic tasks, and therefore a balance needs to be struck between a collaborative and a more egocentric disposition. Neurohumoral agents such as oxytocin are known to promote collaborative behaviours in economic tasks, but whether there are opponent agents, and whether these might even affect information aggregation without an economic component, is unknown. Here, we show that an androgen hormone, testosterone, acts as such an agent. Testosterone causally disrupted collaborative decision-making in a perceptual decision task, markedly reducing performance benefit individuals accrued from collaboration while leaving individual decision-making ability unaffected. This effect emerged because testosterone engendered more egocentric choices, manifest in an overweighting of one's own relative to others' judgements during joint decision-making. Our findings show that the biological control of social behaviour is dynamically regulated not only by modulators promoting, but also by those diminishing a propensity to collaborate. 相似文献
72.
Klopell FC Lemos M Sousa JP Comunello E Maistro EL Bastos JK de Andrade SF 《Zeitschrift für Naturforschung. C, Journal of biosciences》2007,62(7-8):537-542
In this study, the antiulcerogenic effect of essential oil from Baccharis dracunculifolia was evaluated using the model of acute gastric lesions induced by ethanol. The ulcerative lesion index (ULI) was significantly reduced by oral administration of the essential oil of B. dracunculifolia at doses of 50, 250 and 500 mg/kg which reduced the lesions by 42.79, 45.70 and 61.61%, respectively. The analysis of the chemical composition of the essential oil from B. dracunculifolia by GC showed that this was composed mainly of mono- and sesquiterpenes and the majority compound was nerolidol. Therefore, antiulcerogenic activity of nerolidol (50, 250 and 500 mg/kg) was investigated using ethanol-, indomethacin- and stress-induced ulcer models in rat. In the stress-induced ulcer model, a significant reduction of the ULI in animals treated with nerolidol (50, 250 and 500 mg/kg) and cimetidine (100 mg/kg) was observed, compared to the control group (p < 0.05). The percentage of inhibition of ulcer was 41.22, 51.31, 56.57 and 53.50% in groups treated with 50, 250, 500 mg/kg of nerolidol and 100 mg/kg of cimetidine (positive control), respectively. Regarding ethanol- and indomethacin-induced ulcer models, it was observed that the treatment with nerolidol (250 and 500 mg/ kg) significantly reduced the ULI in comparison with the control group (p < 0.05). The dose of 50 mg/kg reduced the parameters analyzed but this was not statistically significant. In the ethanol-induced model percentage of inhibition of ulcer was 34.20, 52.63, 87.63 and 50.87% in groups treated with 50, 250, 500 mg/kg of nerolidol and 30 mg/kg of omeprazol (positive control), respectively. In indomethacin-ulcer the percentage of inhibition of ulcer was 34.69, 40.80, 51.02 and 46.93% in groups treated with 50, 250, 500 mg/kg of nerolidol and 100 mg/ kg of cimetidine (positive control), respectively. The results of this study show that nerolidol displays antiulcer activity, as it significantly inhibited the formation of ulcers induced in different animal models. However, further pharmacological and toxicological investigations, to delineate the mechanism(s) of action and the toxic effects, are required to allow the use of nerolidol for the treatment of gastric ulcer. 相似文献
73.
Betine Pinto Moehlecke Iser Deborah Carvalho Malta Bruce Bartholow Duncan Lenildo de Moura álvaro Vigo Maria Inês Schmidt 《PloS one》2014,9(9)
Introduction
The prevalence of diabetes is increasing worldwide. The objective of this study is to estimate the prevalence of self-reported diabetes in Brazilian adults and to describe its population correlates as well as the clinical characteristics of the reported cases.Methods
We analyzed basic and supplementary data of 54.144 subjects participating in VIGITEL 2011 (Surveillance System for Risk and Protective Factors for Chronic Diseases), a telephone survey based on a probabilistic sample of subjects ≥18 years old residing in Brazilian state capitals and the Federal District. Estimates reported are weighted so as to represent the surveyed population.Results
The prevalence of self-reported diabetes was 6.3% (95% CI 5.9–6.7), increasing markedly with age and nutritional status, and decreasing with level of education. Prevalence was higher among those self-declaring their race/color as black. Most cases (90%) reported the diagnosis being made at 35 years or older. The vast majority (99.8%) of self-reported cases informed having previously performed at least one glucose test, and 76% of those not reporting diabetes also informed having previously performed glucose testing. Most cases (92.6%) reported following some form of diabetes treatment, 79% taking medication.Conclusion
The estimated prevalence of known diabetes found, 6.3%, is consistent with estimates given by international summaries. The additional data collected in VIGITEL 2011 regarding previous glucose testing and current treatment support the use of telephone-based information to monitor the prevalence of known diabetes in Brazilian capitals. 相似文献74.
Anaclara Pincelli Marly A. Cardoso Maíra B. Malta Igor C. Johansen Rodrigo M. Corder Vanessa C. Nicolete Irene S. Soares Marcia C. Castro Marcelo U. Ferreira 《PLoS neglected tropical diseases》2021,15(7)
BackgroundMalaria causes significant morbidity and mortality in children under 5 years of age in sub-Saharan Africa and the Asia-Pacific region. Neonates and young infants remain relatively protected from clinical disease and the transplacental transfer of maternal antibodies is hypothesized as one of the protective factors. The adverse health effects of Plasmodium vivax malaria in early childhood–traditionally viewed as a benign infection–remain largely neglected in relatively low-endemicity settings across the Amazon.Methodology/Principal findingsOverall, 1,539 children participating in a birth cohort study in the main transmission hotspot of Amazonian Brazil had a questionnaire administered, and blood sampled at the two-year follow-up visit. Only 7.1% of them experienced malaria confirmed by microscopy during their first 2 years of life– 89.1% of the infections were caused by P. vivax. Young infants appear to be little exposed to, or largely protected from infection, but children >12 months of age become as vulnerable to vivax malaria as their mothers. Few (1.4%) children experienced ≥4 infections during the 2-year follow-up, accounting for 43.4% of the overall malaria burden among study participants. Antenatal malaria diagnosed by microscopy during pregnancy or by PCR at delivery emerged as a significant correlate of subsequent risk of P. vivax infection in the offspring (incidence rate ratio, 2.58; P = 0.002), after adjusting for local transmission intensity. Anti-P. vivax antibodies measured at delivery do not protect mothers from subsequent malaria; whether maternal antibodies transferred to the fetus reduce early malaria risk in children remains undetermined. Finally, recent and repeated vivax malaria episodes in early childhood are associated with increased risk of anemia at the age of 2 years in this relatively low-endemicity setting.Conclusions/SignificanceAntenatal infection increases the risk of vivax malaria in the offspring and repeated childhood P. vivax infections are associated with anemia at the age of 2 years. 相似文献
75.
Irene Pala Manfred Schartl Miguel Brito Joana Malta Vacas Maria Manuela Coelho 《Proceedings. Biological sciences / The Royal Society》2010,277(1699):3519-3525
The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the distribution range of the complex. Here we show that the allele-specific patterns of silencing vary within the complex, according to the geographical origin and the type of genome involved in the hybridization process. In southern populations, triploids of S. alburnoides show an overall tendency for silencing the allele from the minority genome, while northern population polyploids exhibit preferential biallelic gene expression patterns, irrespective of genomic composition. The present findings further suggest that gene copy silencing and variable expression of specific allele combinations may be important processes in vertebrate polyploid evolution. 相似文献
76.
Research note: Identity of the Qingdao algal bloom 总被引:2,自引:0,他引:2
Frederik Leliaert Xiaowen Zhang Naihao Ye Erik-jan Malta Aschwin H. Engelen Frédéric Mineur Heroen Verbruggen Olivier De Clerck 《Phycological Research》2009,57(2):147-151
In early July 2008, news agencies worldwide reported on a vast algal bloom that was threatening the upcoming Olympic sailing events in Qingdao, China. The identity of the culpable alga, however, remained undiscussed. We have identified the alga that caused the bloom by means of morphological and molecular data, including sequence data of the plastid encoded large subunit ribulose 1,5-bisphosphate carboxylase gene ( rbc L) and the nuclear encoded rDNA internal transcribed spacer (ITS) region. The bloom-forming alga falls within the morphological limits of the green seaweed Ulva prolifera O.F. Müller (' Enteromorpha prolifera (O.F. Müller) J. Agardh') but our phylogenetic analyses show that it forms a clade with representatives of the Ulva linza-procera-prolifera (LPP) complex. The Chinese rbc L sequences are identical to those of specimens collected from Japan, New Zealand, Finland and Portugal, suggesting that the taxon is widely distributed. rDNA ITS sequences showed a close affinity with Japanese isolates of the species complex. The Qingdao bloom is a typical illustration of a green tide, which occurs increasingly along several coasts worldwide. 相似文献
77.
The chromosome complement of a local population of Astyanax scabripinnis in Brazil was investigated with emphasis on the study of the heterochromatin attached to the A-chromosomes and present in
the macro B-chromosome. Analysis after C-banding, silver and CMA3 staining, incorporation of 5-bromo-2′-deoxyuridine and chromosome digestion with nine restriction endonucleases revealed
that the heterochromatin in the B-chromosomes was different from that found in the A-chromosomes. A polymorphism due to the
presence of a supernumerary heterochromatic chromosome segment was observed in the population investigated. Some aspects related
to the origin of the heterochromatin polymorphism in Astyanax scabripinnis are discussed.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
78.
Chemical treatment of uranium mine acid drainage generates sludge containing high radioactivity levels with, for example, 238U and 226Ra concentrations at about 18 and 9 kBq kg−1 dry weight, respectively. Spontaneous vegetation, such as grass (Polygonum sp.), reeds (Phragmites australis), and bullrush (Typha latifolia) growing in sludge dewatering ponds concentrated uranium and uranium daughter radionuclides. However, bullrush growing in natural wetlands by the stream receiving treated mine water discharges contained even higher radionuclide concentrations, e.g., 21 Bq kg−1 dry weight of 238U, about four times higher than bullrush growing on sludge, probably because the uranium in water is more bioavailable to Typha than uranium in the chemical sludge. It is suggested that wetlands with plant species could be used as a secondary treatment to further reduce radioactivity in chemically treated uranium mine water and to improve water quality in streams receiving treated water discharges. Furthermore, it is concluded that vegetation both from sludge drying ponds and from streams receiving treated water discharges, due to the high radionuclide concentrations in the vegetation, is not suitable as cattle feeding. 相似文献
79.
Rui Fernando da Silva Andréa Carla de Almeida Barros Márcia Pletsch Adriana Carla Cavalcante Malta Argolo Brancilene Santos de Araujo 《World journal of microbiology & biotechnology》2010,26(10):1761-1767
Scavenging and anti-Staphylococcus
aureus activities of extracts, fractions and subfractions from the in vitro mycelium of two strains of the edible mushroom Volvariella volvacea were determined. Chloroform subfractions of the ATCC62890 strain showed the highest inhibition percentage of the DPPH radical
(over 80%) after 180 min. When chloroform and hexane subfractions of the R83 strain were combined they showed moderate (inhibition
zone of 8.99 ± 0.78 mm) to high (inhibition zone of 13.06 ± 0.41 mm) activity against the Gram-positive bacteria Staphylococcus
aureus, which are 74.4 and 51.2% of tetracycline (inhibition zone of 17.55 ± 0.11 mm). Partitioning suggested that the substances
in the chloroform and hexane fractions of the R83 strain act synergistically to give the antimicrobial activity, while separating
the substances of the ATCC62890 subfractions reduced their activity. In general, the R83 strain seems to be a source of antimicrobial
substances, while the ATCC62890 strain appears to be an alternative source of antioxidants. 相似文献
80.
Caio Noritake Louzada Ana Paula de Souza Maistro Emygdio Leite de Araujo Monteiro-Filho 《Acta ethologica》2014,17(2):113-117
Some difficulties arise in studying the behaviour of marine mammals at their natural habitat mainly because they spend most of their time underwater and have complex behaviours. Therefore, many protocols and sample methods are available to better assess the behavioural ecology of this animals. Here, we compared two behavioural recording methods. The first one was the direct visual observation. The second one was recording using a digital video recorder. We hypothesise that the possibility of watching recorded videos repeatedly leads to a higher quantification of behaviours compared with the direct observation method. We found a slight variation in the frequency of behaviours according to the method used. Furthermore, we found that the video recordings should not be used as a replacement for the direct observation method. Finally, we highlighted the strengths and weaknesses of both methods. We recommend that in behavioural research, the use of video recording should be careful; it is preferable that an experienced researcher uses the direct observation method, while it is best for a person with low know–how to the use the video recording method. 相似文献