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BK McNab 《New Zealand journal of zoology.》2016,43(2):179-190
The energy expenditure of the tūī (Prosthemadera novaeseelandiae), a meliphagid endemic to New Zealand, was measured and compared with 20 species of honeyeaters (family Meliphagidae) to determine whether its expenditure is influenced either by life in a moist, temperate climate or an island residence. Body mass in the honeyeaters accounted for 91.5% of the variation in basal rate. The combination of body mass, climate and the maximal limit to an altitudinal distribution explained 98.6% of the variation in basal rate with tropical, low-altitude species having the highest mass-independent rate. The basal rates of meliphagids in tropical highlands are similar to those in temperate lowlands, which may reflect similar food supplies. The tūī mass-independent expenditure appears to reflect an active lifestyle in a temperate climate with no evidence that an island residence influenced its rate, whereas sedentary birds on New Zealand have responded to island life with a depressed basal rate. An effective analysis of the variation in energy expenditure requires the inclusion of the ecological and behavioural characteristics that distinguish species. 相似文献
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Raghavan S Tria GS Shen HC Ding FX Taggart AK Ren N Wilsie LC Krsmanovic ML Holt TG Wolff MS Waters MG Hammond ML Tata JR Colletti SL 《Bioorganic & medicinal chemistry letters》2008,18(11):3163-3167
The design, synthesis, and biological activity of a series of cycloalkene acid-based niacin receptor agonists are described. This led to the discovery that tetrahydro anthranilic acid is an excellent surrogate for anthranilic acid. Several compounds were identified that were potent against the niacin receptor, had enhanced cytochrome P450 selectivity against subtypes CYP2C8 and CYP2C9, and improved oral exposure in mice. 相似文献
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Hong C. Shen Fa-Xiang Ding Sheo B. Singh Gopalakrishnan Parthasarathy Stephen M. Soisson Sookhee N. Ha Xun Chen Srinivas Kodali Jun Wang Karen Dorso James R. Tata Milton L. Hammond Malcolm MacCoss Steven L. Colletti 《Bioorganic & medicinal chemistry letters》2009,19(6):1623-1627
Platensimycin (1) displays antibacterial activity due to its inhibition of the elongation condensing enzyme (FabF), a novel mode of action that could potentially lead to a breakthrough in developing a new generation of antibiotics. The medicinal chemistry efforts were focused on the modification of the enone moiety of platensimycin and several analogs showed significant activity against FabF and possess antibacterial activity. 相似文献
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Hong C. Shen Fa-Xiang Ding Siyi Wang Suoyu Xu Hsuan-shen Chen Xinchun Tong Vincent Tong Kaushik Mitra Sanjeev Kumar Xiaoping Zhang Yuli Chen Gaochao Zhou Lee-Yuh Pai Magdalena Alonso-Galicia Xiaoli Chen Bei Zhang James R. Tata Joel P. Berger Steven L. Colletti 《Bioorganic & medicinal chemistry letters》2009,19(13):3398-3404
Spirocyclic secondary amine-derived trisubstituted ureas were identified as highly potent, bioavailable and selective soluble epoxide hydrolase (sEH) inhibitors. Despite good oral exposure and excellent ex vivo target engagement in blood, one such compound, rac-1a, failed to lower blood pressure acutely in spontaneously hypertensive rats (SHRs). This study posed the question as to whether sEH inhibition provides a robust mechanism leading to a significant antihypertensive effect. 相似文献
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We present a mathematical method for acceleration workspace analysis of cooperating multi-finger robot systems using a model of point-contact with friction. A new unified formulation from dynamic equations of cooperating multi-finger robots is derived considering the force and acceleration relationships between the fingers and the object to be handled. From the dynamic equation, maximum translational and rotational acceleration bounds of an object are calculated under given constraints of contact conditions, configurations of fingers, and bounds on the torques of joint actuators for each finger. Here, the rotational acceleration bounds can be applied as an important manipulability index when the multi-finger robot grasps an object. To verify the proposed method, we used a set of case studies with a simple multi-finger mechanism system. The achievable acceleration boundary in task space can be obtained successfully with the proposed method and the acceleration boundary depends on the configurations of fingers. 相似文献
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Subcellular redistribution of liver α-glucan phosphorylase during alterations in glycogen content 总被引:5,自引:0,他引:5
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J. R. Tata 《The Biochemical journal》1964,90(2):284-292