全文获取类型
收费全文 | 358篇 |
免费 | 32篇 |
国内免费 | 2篇 |
出版年
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 4篇 |
2018年 | 14篇 |
2017年 | 19篇 |
2016年 | 7篇 |
2015年 | 13篇 |
2014年 | 5篇 |
2013年 | 25篇 |
2012年 | 23篇 |
2011年 | 20篇 |
2010年 | 8篇 |
2009年 | 8篇 |
2008年 | 16篇 |
2007年 | 21篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 17篇 |
2003年 | 17篇 |
2002年 | 18篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 5篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 8篇 |
1989年 | 11篇 |
1988年 | 6篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1979年 | 4篇 |
1977年 | 2篇 |
1975年 | 3篇 |
1973年 | 3篇 |
1970年 | 2篇 |
1968年 | 2篇 |
1966年 | 2篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1951年 | 1篇 |
排序方式: 共有392条查询结果,搜索用时 46 毫秒
71.
Based on the morphological characteristics of the skull and teeth, Hanihara ([1991] Japan Review 2:1–33) proposed the “dual structure model” for the formation of modern Japanese populations. We examine this model by dividing it into two independent hypotheses: 1) the Upper Paleolithic population of Japan that gave rise to the Neolithic Jomon people was of southeast Asian origin, and 2) modern Ainu and Ryukyuan (Okinawa) populations are direct descendants of the Jomon people, while Hondo (Main Island)-Japanese are mainly derived from the migrants from the northeast Asian continent after the Aeneolithic Yayoi period. Our aim is to examine the extent to which the model is supported by genetic evidence from modern populations, particularly from Japan and other Asian areas. Based on genetic distance analyses using data from up to 25 “classic” genetic markers, we find first that the three Japanese populations including Ainu and Ryukyuan clearly belong to a northeast Asian cluster group. This negates the first hypothesis of the model. Then, we find that Ainu and Ryukyuans share a group contrasting with Hondo-Japanese and Korean, supporting the second hypothesis of the model. Based on these results, we propose a modified version of the dual structure model which may explain the genetic, morphological, and archaeological evidence concerning the formation of modern Japanese populations. Am J Phys Anthropol 102:437–446, 1997. © 1997 Wiley-Liss, Inc. 相似文献
72.
Establishment of a new conditionally immortalized human skeletal muscle microvascular endothelial cell line
下载免费PDF全文
![点击此处可从《Journal of cellular physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
73.
Takashi Takeshita Yutaka Yamamoto Mutsuko Yamamoto-Ibusuki Mai Tomiguchi Aiko Sueta Keiichi Murakami Yoko Omoto Hirotaka Iwase 《Translational oncology》2017,10(5):766-771
BACKGROUND: ESR1 mutation in circulating cell-free DNA (cfDNA) is emerging as a noninvasive biomarker of acquired resistance to endocrine therapy, but there is a paucity of data comparing the status of ESR1 gene in cfDNA with that in its corresponding tumor tissue. The objective of this study is to validate the degree of concordance of ESR1 mutations between plasma and tumor tissue. METHODS: ESR1 ligand-binding domain mutations Y537S, Y537N, Y537C, and D538G were analyzed using droplet digital PCR in 35 patients with metastatic breast cancer (MBC) (35 tumor tissue samples and 67 plasma samples). RESULTS: Of the 35 paired samples, 26 (74.3%) were concordant: one patient had detectable ESR1 mutations both plasma (ESR1 Y537S/Y537N) and tumor tissue (ESR1 Y537S/Y537C), and 25 had WT ESR1 alleles in both. Nine (25.7%) had discordance between the plasma and tissue results: five had mutations detected only in their tumor tissue (two Y537S, one Y537C, one D538G, and one Y537S/Y537N/D538G), and four had mutations detected only in their plasma (one Y537S, one Y537N, and two Y537S/Y537N/D538G). Furthermore, longitudinal plasma samples from 19 patients were used to assess changes in the presence of ESR1 mutations during treatment. Eleven patients had cfDNA ESR1 mutations over the course of treatment. A total of eight of 11 patients with MBC with cfDNA ESR1 mutations (72.7%) had the polyclonal mutations. CONCLUSION: We have shown the independent distribution of ESR1 mutations between plasma and tumor tissue in 35 patients with MBC. 相似文献
74.
Naohiro Sakata Yoshinobu Hoshii Tomomi Nakamura Makiko Kiyama Hirofumi Arai Masatoshi Omoto Mitsunori Morimatsu Tokuhiro Ishihara 《The journal of histochemistry and cytochemistry》2005,53(2):237-242
Apolipoprotein AI (apoAI), a major component of high-density lipoproteins, is one of the major amyloid fibril proteins and a minor constituent of the senile plaques observed in Alzheimer's disease. We examined colocalization of apoAI in various kinds of systemic amyloidosis in this study. Forty-three of 48 formalin-fixed paraffin-embedded heart specimens with various forms of systemic amyloidosis reacted immunohistochemically with anti-human apoAI antibody. ApoAI was also detected in water-extracted amyloid material by immunoblotting. In addition, we observed colocalization of apoAI and murine amyloid A (AA) amyloidosis in human apoAI transgenic mice. This is the first report of colocalization of apoAI with amyloid deposits in various forms of human systemic amyloidosis and murine AA amyloidosis in human apoAI transgenic mice. ApoAI may not always be a major component of amyloid fibrils, even when it is present in systemic amyloid deposits. 相似文献
75.
Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells 总被引:1,自引:0,他引:1
76.
Kihara T Ichikawa S Yonezawa T Lee JW Akihisa T Woo JT Michi Y Amagasa T Yamaguchi A 《Biochemical and biophysical research communications》2011,(2):211-217
We investigated the effects of acerogenin A, a natural compound isolated from Acer nikoense Maxim, on osteoblast differentiation by using osteoblastic cells. Acerogenin A stimulated the cell proliferation of MC3T3-E1 osteoblastic cells and RD-C6 osteoblastic cells (Runx2-deficient cell line). It also increased alkaline phosphatase activity in MC3T3-E1 and RD-C6 cells and calvarial osteoblastic cells isolated from the calvariae of newborn mice. Acerogenin A also increased the expression of mRNAs related to osteoblast differentiation, including Osteocalcin, Osterix and Runx2 in MC3T3-E1 cells and primary osteoblasts: it also stimulated Osteocalcin and Osterix mRNA expression in RD-C6 cells. The acerogenin A treatment for 3 days increased Bmp-2, Bmp-4, and Bmp-7 mRNA expression levels in MC3T3-E1 cells. Adding noggin, a BMP specific-antagonist, inhibited the acerogenin A-induced increase in the Osteocalcin, Osterix and Runx2 mRNA expression levels. These results indicated that acerogenin A stimulates osteoblast differentiation through BMP action, which is mediated by Runx2-dependent and Runx2-independent pathways. 相似文献
77.
78.
79.
80.
Keisuke Kuwahara Teppei Imai Akiko Nishihara Tohru Nakagawa Shuichiro Yamamoto Toru Honda Toshiaki Miyamoto Takeshi Kochi Masafumi Eguchi Akihiko Uehara Reiko Kuroda Daisuke Omoto Kayo Kurotani Ngoc Minh Pham Akiko Nanri Isamu Kabe Tetsuya Mizoue Naoki Kunugita Seitaro Dohi Japan Epidemiology Collaboration on Occupational Health Study Group 《PloS one》2014,9(5)