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951.
Thomas Riedel Hazuki Teshima J?rn Petersen Anne Fiebig Karen Davenport Hajnalka Daligault Tracy Erkkila Wei Gu Christine Munk Yan Xu Amy Chen Amrita Pati Natalia Ivanova Lynne A. Goodwin Patrick Chain John C. Detter Manfred Rohde Sabine Gronow Nikos C. Kyrpides Tanja Woyke Markus G?ker Thorsten Brinkhoff Hans-Peter Klenk 《Standards in genomic sciences》2013,8(3):389-402
Leisingera aquimarina Vandecandelaere et al. 2008 is a member of the genomically well characterized Roseobacter clade within the family Rhodobacteraceae. Representatives of the marine Roseobacter clade are metabolically versatile and involved in carbon fixation and biogeochemical processes. They form a physiologically heterogeneous group, found predominantly in coastal or polar waters, especially in symbiosis with algae, in microbial mats, in sediments or associated with invertebrates. Here we describe the features of L. aquimarina DSM 24565T together with the permanent-draft genome sequence and annotation. The 5,344,253 bp long genome consists of one chromosome and an unusually high number of seven extrachromosomal elements and contains 5,129 protein-coding and 89 RNA genes. It was sequenced as part of the DOE Joint Genome Institute Community Sequencing Program 2010 and of the activities of the Transregional Collaborative Research Centre 51 funded by the German Research Foundation (DFG). 相似文献
952.
Paul G. Beyersmann Olga Chertkov J?rn Petersen Anne Fiebig Amy Chen Amrita Pati Natalia Ivanova Alla Lapidus Lynne A. Goodwin Patrick Chain John C. Detter Manfred Rohde Sabine Gronow Nikos C. Kyrpides Tanja Woyke Meinhard Simon Markus G?ker Hans-Peter Klenk Thorsten Brinkhoff 《Standards in genomic sciences》2013,8(3):403-419
In 2009 Phaeobacter caeruleus was described as a novel species affiliated with the marine Roseobacter clade, which, in turn, belongs to the class Alphaproteobacteria. The genus Phaeobacter is well known for members that produce various secondary metabolites. Here we report of putative quorum sensing systems, based on the finding of six N-acyl-homoserine lactone synthetases, and show that the blue color of P. caeruleus is probably due to the production of the secondary metabolite indigoidine. Therefore, P. caeruleus might have inhibitory effects on other bacteria. In this study the genome of the type strain DSM 24564T was sequenced, annotated and characterized. The 5,344,419 bp long genome with its seven plasmids contains 5,227 protein-coding genes (3,904 with a predicted function) and 108 RNA genes. 相似文献
953.
Wayne Reeve Kemanthi Nandasena Ron Yates Ravi Tiwari Graham O’Hara Mohamed Ninawi Olga Chertkov Lynne Goodwin David Bruce Chris Detter Roxanne Tapia Shunseng Han Tanja Woyke Sam Pitluck Matt Nolan Miriam Land Alex Copeland Konstantinos Liolios Amrita Pati Konstantinos Mavromatis Victor Markowitz Nikos Kyrpides Natalia Ivanova Lynne Goodwin Uma Meenakshi John Howieson 《Standards in genomic sciences》2013,9(2):294-303
Mesorhizobium opportunistum strain WSM2075T was isolated in Western Australia in 2000 from root nodules of the pasture legume Biserrula pelecinus that had been inoculated with M. ciceri bv. biserrulae WSM1271. WSM2075T is an aerobic, motile, Gram negative, non-spore-forming rod that has gained the ability to nodulate B. pelecinus but is completely ineffective in N2 fixation with this host. This report reveals that the genome of M. opportunistum strain WSM2075T contains a chromosome of size 6,884,444 bp, encoding 6,685 protein-coding genes and 62 RNA-only encoding genes. The genome contains no plasmids, but does harbor a 455.7 kb genomic island from Mesorhizobium ciceri bv. biserrulae WSM1271 that has been integrated into a phenylalanine-tRNA gene. 相似文献
954.
Thomas Kruse Julien Maillard Lynne Goodwin Tanja Woyke Hazuki Teshima David Bruce Chris Detter Roxanne Tapia Cliff Han Marcel Huntemann Chia-Lin Wei James Han Amy Chen Nikos Kyrpides Ernest Szeto Victor Markowitz Natalia Ivanova Ioanna Pagani Amrita Pati Sam Pitluck Matt Nolan Christof Holliger Hauke Smidt 《Standards in genomic sciences》2013,8(3):375-388
Dehalobacter restrictus strain PER-K23 (DSM 9455) is the type strain of the species Dehalobacter restrictus. D. restrictus strain PER-K23 grows by organohalide respiration, coupling the oxidation of H2 to the reductive dechlorination of tetra- or trichloroethene. Growth has not been observed with any other electron donor or acceptor, nor has fermentative growth been shown. Here we introduce the first full genome of a pure culture within the genus Dehalobacter. The 2,943,336 bp long genome contains 2,826 protein coding and 82 RNA genes, including 5 16S rRNA genes. Interestingly, the genome contains 25 predicted reductive dehalogenase genes, the majority of which appear to be full length. The reductive dehalogenase genes are mainly located in two clusters, suggesting a much larger potential for organohalide respiration than previously anticipated. 相似文献
955.
Renate B. Schnabel Matthias Michal Sandra Wilde J?rg Wiltink Philipp S. Wild Christoph R. Sinning Edith Lubos Francisco M. Ojeda Tanja Zeller Thomas Munzel Stefan Blankenberg Manfred E. Beutel 《PloS one》2013,8(12)
Background
Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited.Methods and Results
In 10,000 individuals (mean age 56±11 years, 49.4% women) of the population-based Gutenberg Health Study we assessed depression by the Patient Health Questionnaire (PHQ-9) and a history of depression in relation to manifest atrial fibrillation (n = 309 cases). The median (25th/75th percentile) PHQ-9 score of depressive symptoms was 4 (2/6) in atrial fibrillation individuals versus 3 (2/6) individuals without atrial fibrillation, . Multivariable regression analyses of the severity of depressive symptoms in relation to atrial fibrillation in cardiovascular risk factor adjusted models revealed a relation of PHQ-9 values and atrial fibrillation (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01–1.08; P = 0.023). The association was stronger for the somatic symptom dimension of depression (OR 1.08, 95% CI 1.02–1.15; P = 0.0085) than for cognitive symptoms (OR 1.05, 95% CI 0.98–1.11; P = 0.15). Results did not change markedly after additional adjustment for heart failure, partnership status or the inflammatory biomarker C-reactive protein. Both, self-reported physical health status, very good/good versus fair/bad, (OR 0.54, 95% CI 0.41–0.70; P<0.001) and mental health status (OR 0.61 (0.46–0.82); P = 0.0012) were associated with atrial fibrillation in multivariable-adjusted models.Conclusions
In a population-based sample we observed a higher burden of depressive symptoms driven by somatic symptom dimensions in individuals with atrial fibrillation. Depression was associated with a worse perception of physical or mental health status. Whether screening and treatment of depressive symptoms modulates disease progression and outcome needs to be shown. 相似文献956.
Michael Weiss Anna I. Kesberg Kurt M. LaButti Sam Pitluck David Bruce Loren Hauser Alex Copeland Tanja Woyke Stephen Lowry Susan Lucas Miriam Land Lynne Goodwin Staffan Kjelleberg Alasdair M. Cook Matthias Buhmann Torsten Thomas David Schleheck 《Standards in genomic sciences》2013,8(2):239-254
Comamonas testosteroni KF-1 is a model organism for the elucidation of the novel biochemical degradation pathways for xenobiotic 4-sulfophenylcarboxylates (SPC) formed during biodegradation of synthetic 4-sulfophenylalkane surfactants (linear alkylbenzenesulfonates, LAS) by bacterial communities. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 6,026,527 bp long chromosome (one sequencing gap) exhibits an average G+C content of 61.79% and is predicted to encode 5,492 protein-coding genes and 114 RNA genes. 相似文献
957.
Marco Dogs Sonja Voget Hazuki Teshima J?rn Petersen Karen Davenport Hajnalka Dalingault Amy Chen Amrita Pati Natalia Ivanova Lynne A. Goodwin Patrick Chain John C. Detter Sonja Standfest Manfred Rohde Sabine Gronow Nikos C. Kyrpides Tanja Woyke Meinhard Simon Hans-Peter Klenk Markus G?ker Thorsten Brinkhoff 《Standards in genomic sciences》2013,9(2):334-350
958.
Bettina Reichenbacher Gary R. Feulner Tanja Schulz‐Mirbach 《Journal of morphology》2009,270(4):469-484
Aphanius Nardo is a large genus of teleost fishes in the Old World, with 19 described species. Several of these species have only recently been recognized and additional species can be expected from isolated populations in remote areas. We show here that otolith morphology and statistical analyses of otolith variables can contribute to the detection of genetic differentiation in Aphanius. We studied samples of eight Aphanius dispar populations from the southeastern part of the Arabian Peninsula. Two populations originate from freshwater habitats far inland and probably have been isolated since the late Holocene some 4,000 years ago, three populations come from freshwater habitats with occasional connections to the sea, one population originates from a coastal site, and two were artificially introduced populations. The coastal population is interpreted as possessing the basic otolith type of A. dispar. The basic otolith type also occurs in fishes from the freshwater habitat which is located closest to the coast. Otoliths from the two other freshwater populations with occasional connections to the coast differ slightly from the basic type. However, the two populations from the long‐term isolated freshwater habitats far inland show distinct morphological changes. Our results are consistent with the hypotheses that i) otolith morphology is primarily genetically determined and is little influenced by physical parameters of the habitat, and ii) isolated A. dispar populations may be capable of evolving into new species within short periods of time. J. Morphol., 2009. © 2008 Wiley‐Liss, Inc. 相似文献
959.
The process of cell migration is definied by biochemical and biophysical properties of the invading cells. Accelarated investigations in the field of biomechanics are of high impact regarding the process of the migration into a 3‐D matrix of tumor cells. In contrast to use of several protein markers that determine tumor malignancy, a single cell mechanical parameter may delevop as a reliable, standard tool for tumor diagnostics. The cell mechanics of living cells shed light on tumor disease especially on the process of metastasis that involves the invasion of tumor cells through connective tissue. 相似文献
960.
Heidi O. Nousiainen Ileana B. Quintero Timo T. My?h?nen Vootele Voikar Jelena Mijatovic Mikael Segerstr?le Annakaisa M. Herrala Natalia Kulesskaya Anitta E. Pulkka Tanja Kivinummi Usama Abo-Ramadan Tomi Taira T. Petteri Piepponen Heikki Rauvala Pirkko Vihko 《PloS one》2014,9(5)
Prostatic acid phosphatase (PAP), the first diagnostic marker and present therapeutic target for prostate cancer, modulates nociception at the dorsal root ganglia (DRG), but its function in the central nervous system has remained unknown. We studied expression and function of TMPAP (the transmembrane isoform of PAP) in the brain by utilizing mice deficient in TMPAP (PAP−/− mice). Here we report that TMPAP is expressed in a subpopulation of cerebral GABAergic neurons, and mice deficient in TMPAP show multiple behavioral and neurochemical features linked to hyperdopaminergic dysregulation and altered GABAergic transmission. In addition to increased anxiety, disturbed prepulse inhibition, increased synthesis of striatal dopamine, and augmented response to amphetamine, PAP-deficient mice have enlarged lateral ventricles, reduced diazepam-induced loss of righting reflex, and increased GABAergic tone in the hippocampus. TMPAP in the mouse brain is localized presynaptically, and colocalized with SNARE-associated protein snapin, a protein involved in synaptic vesicle docking and fusion, and PAP-deficient mice display altered subcellular distribution of snapin. We have previously shown TMPAP to reside in prostatic exosomes and we propose that TMPAP is involved in the control of GABAergic tone in the brain also through exocytosis, and that PAP deficiency produces a distinct neurological phenotype. 相似文献