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181.
Tamar Schaap 《Human genetics》1989,82(1):79-81
Summary The frequency of recombination in the regions adjacent to the fragile X locus was studied in two groups of carriers: daughters of transmitting males and transmitters of maternally inherited fragile X chromosomes. Approximately one-half of the offspring of the former and one quarter of the off-spring of the latter are recombinant. Recombinants and parentals are equally distributed among affected and normal off-spring in the two groups. These results indicate that crossing-over at or around the fragile X locus occurs in every meiosis in doughters of transmitting males, although the recombinant chromatids do not necessarily carry the fragile X mutation. Hence, crossing-over is unequivocally associated with, but is not the direct cause of, the transition from the primary genetic lesion to the final mutation. 相似文献
182.
A model of handwriting 总被引:1,自引:1,他引:0
The research reported here is concerned with hand trajectory planning for the class of movements involved in handwriting. Previous studies show that the kinematics of human two-joint arm movements in the horizontal plane can be described by a model which is based on dynamic minimization of the square of the third derivative of hand position (jerk), integrated over the entire movement. We extend this approach to both the analysis and the synthesis of the trajectories occurring in the generation of handwritten characters. Several basic strokes are identified and possible stroke concatenation rules are suggested. Given a concise symbolic representation of a stroke shape, a simple algorithm computes the complete kinematic specification of the corresponding trajectory. A handwriting generation model based on a kinematics from shape principle and on dynamic optimization is formulated and tested. Good qualitative and quantitative agreement was found between subject recordings and trajectories generated by the model. The simple symbolic representation of hand motion suggested here may permit the central nervous system to learn, store and modify motor action plans for writing in an efficient manner. 相似文献
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185.
It is proposed that surface scums of densely packed planktoniccyanobacteria (blue-green algae) which exist for weeks to months,measure several decimeters in thickness and are covered by acrust of photo-oxidized cells, be called hyperscums. Hyperscumsof Microcystis aeruginosa formed during prolonged periods ofcalm weather in wind-protected sites in a hypertrophic lakesubject to low wind speeds (Hart beespoort Dam, South Africa).A hyperscum that extended over 12 hectares and persistedfor 103 days during winter 1983 was studied. Chlorophyll a concentrationsranged from 100 to 300 mg l2 Microcystis cell concentrationsreached 1.76x109 cells ml1 or 116 cm3l1. The hyperscumenvironment was anoxic, aphotic, with a fluctuating temperatureregime and low pH values. The densely packed Microcystis cellssurvived these conditions for more than 2 months. This was shownby comparing the potential photosynthetic capacity of Microcystisfrom the hyperscum with that of Microcystis from the main basinof the lake. However, after 3 months the hyperscum algae losttheir photosynthetic capacity and decomposition processes prevailed.The hyperscum gradually shrank in size until a storm causedits complete disintegration. 相似文献
186.
Karin Tamar Pelagia Mitsi Salvador Carranza 《Journal of Zoological Systematics and Evolutionary Research》2019,57(2):369-382
Asaccus geckos are distributed in southwest Asia, mainly in Iran and Arabia. Currently, seven Asaccus species are recognized in Arabia, all endemic to the isolated Hajar Mountains in Oman and the UAE, an area regarded as a biodiversity and endemicity hotspot. Previous phylogenetic studies have shown a non‐monophyletic structure of the Arabian Asaccus species, with the Hajar endemic A. montanus diverging first from the remaining Iranian and Arabian taxa, thus suggesting a possible Arabian origin for the genus. Despite the species’ obvious phylogeographical importance, no study has yet explored its intraspecific diversity. In this study, we assessed the genetic diversity and phylogeography of A. montanus and its phylogenetic relationships with the rest of the Arabian Asaccus species and some available representatives from Iran. We used both mitochondrial and nuclear data to assess phylogenetic relationships based on haplotype networks, concatenated datasets and species trees, performed species delimitation analyses, and estimated divergence times and genetic diversity. We suggest Asaccus began diverging during the Middle Oligocene, a period of major tectonic activity in and around Arabia. Our results mainly support previous phylogenetic studies and uncover the presence of cryptic diversity within A. montanus. Asaccus montanus diverged in the Jebel Akhdar Mountain range into two deep allopatric lineages during the Late Pliocene. Our findings suggest further taxonomic research is necessary for this species, especially due to its vulnerable status and restricted range in an area of great conservation importance. 相似文献
187.
Theodoros B Grivas Marian H Wade Stefano Negrini Joseph P O'Brien Toru Maruyama Martha C Hawes Manuel Rigo Hans Rudolf Weiss Tomasz Kotwicki Elias S Vasiliadis Lior Neuhaus Sulam Tamar Neuhous 《Scoliosis》2007,2(1):1-23
This report is the SOSORT Consensus Paper on School Screening for Scoliosis discussed at the 4th International Conference on Conservative Management of Spinal Deformities, presented by SOSORT, on May 2007. The objectives were numerous, 1) the inclusion of the existing information on the issue, 2) the analysis and discussion of the responses by the meeting attendees to the twenty six questions of the questionnaire, 3) the impact of screening on frequency of surgical treatment and of its discontinuation, 4) the reasons why these programs must be continued, 5) the evolving aim of School Screening for Scoliosis and 6) recommendations for improvement of the procedure. 相似文献
188.
Chatziefthimiou AD Crespo-Medina M Wang Y Vetriani C Barkay T 《Extremophiles : life under extreme conditions》2007,11(3):469-479
Mercury rich geothermal springs are likely environments where mercury resistance is critical to microbial life and where microbe-mercury
interactions may have evolved. Eleven facultative thermophilic and chemolithoautotrophic, thiosulfate oxidizing bacteria were
isolated from thiosulfate enrichments of biofilms from mercury rich hot sulfidic springs in Mount Amiata, Italy. Some strains
were highly resistant to mercury (≥200 μM HgCl2) regardless of its presence or absence during primary enrichments, and three reduced ionic mercury to its elemental form.
The gene encoding for the mercuric reductase enzyme (MerA), was amplified by PCR from seven strains. However, one highly resistant
strain did not reduce mercury nor carried merA, suggesting an alternative resistance mechanism. All strains were members of the order Bacillales and were most closely related to previously described thermophiles belonging to the Firmicutes. Phylogenetic analyses clustered the MerA of the isolates in two supported novel nodes within the Firmicutes lineage and a comparison with the 16S rRNA gene tree suggested at least one case of horizontal gene transfer. Overall, the
results show that the thermophilic thiosulfate oxidizing isolates were adapted to life in presence of mercury mostly, but
not exclusively, by possessing MerA. These findings suggest that reduction of mercury by chemolithotrophic thermophilic bacteria
may mobilize mercury from sulfur and iron deposits in geothermal environments. 相似文献
189.
Nino Porakishvili Ketki Vispute Andrew J Steele Nadeeka Rajakaruna Nina Kulikova Tamar Tsertsvadze Amit Nathwani Rajendra N Damle Edward A Clark Kanti R Rai Nicholas Chiorazzi Peter M Lydyard 《Molecular medicine (Cambridge, Mass.)》2015,21(1):46-57
Chronic lymphocytic leukemia (CLL) development and progression are thought to be driven by unknown antigens/autoantigens through the B cell receptor (BCR) and environmental signals for survival and expansion including toll-like receptor (TLR) ligands. CD180/RP105, a membrane-associated orphan receptor of the TLR family, induces normal B cell activation and proliferation and is expressed by approximately 60% of CLL samples. Half of these respond to ligation with anti-CD180 antibody by increased activation/phosphorylation of protein kinases associated with BCR signaling. Hence CLL cells expressing both CD180 and the BCR could receive signals via both receptors. Here we investigated cross-talk between BCR and CD180-mediated signaling on CLL cell survival and apoptosis. Our data indicate that ligation of CD180 on responsive CLL cells leads to activation of either prosurvival Bruton tyrosine kinase (BTK)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT-mediated, or proapoptotic p38 mitogen-activated protein kinase (p38MAPK)-mediated signaling pathways, while selective immunoglobulin M (sIgM) ligation predominantly engages the BTK/PI3K/AKT pathway. Furthermore, pretreatment of CLL cells with anti-CD180 redirects IgM-mediated signaling from the prosurvival BTK/PI3K/AKT toward the proapoptotic p38MAPK pathway. Thus preengaging CD180 could prevent further prosurvival signaling mediated via the BCR and, instead, induce CLL cell apoptosis, opening the door to therapeutic profiling and new strategies for the treatment of a substantial cohort of CLL patients. 相似文献
190.