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111.
Crystal structure of Ufc1, the Ufm1-conjugating enzyme 总被引:2,自引:0,他引:2
Mizushima T Tatsumi K Ozaki Y Kawakami T Suzuki A Ogasahara K Komatsu M Kominami E Tanaka K Yamane T 《Biochemical and biophysical research communications》2007,362(4):1079-1084
Ubiquitin and ubiquitin-like protein-conjugating enzymes play central roles in posttranslational modification processes. The ubiquitin-fold modifier 1 (Ufm1), one of a variety of ubiquitin-like modifiers, is covalently attached to target proteins via Uba5 and Ufm1-conjugating enzyme 1 (Ufc1), which are analogous to the E1 and E2 ubiquitylation enzymes. As Ufm1-related proteins are conserved in metazoa and plants, the Ufm1 system likely plays important roles in various multicellular organisms. Herein, we report the X-ray structure of human Ufc1 determined at 1.6 A resolution. The Ufc1 structure comprises a canonical E2 domain and an additional N-terminal domain. The Uba5 binding site on Ufc1 was assigned by structural comparison of Ufc1 and Ubc12 and related mutational analyses. In addition, we show that the N-terminal unique domain of Ufc1 contributes to thermal stability. 相似文献
112.
Aoi W Naito Y Nakamura T Akagiri S Masuyama A Takano T Mizushima K Yoshikawa T 《The Journal of nutritional biochemistry》2007,18(2):140-145
Milk fermented with a starter containing Lactobacillus helveticus and Saccharomyces cerevisiae is drunk on a daily basis by many people in Japan and has several beneficial effects. We studied the influence of this fermented milk product on muscle damage after prolonged exercise in rats. Wistar rats were divided into four groups: rested controls, rested rats given fermented milk diet, exercised rats and exercised rats given fermented milk diet. After 3 weeks of acclimatization, both exercise groups were made to run on a treadmill at 26 m/min for 60 min. Exercise increased the serum creatine kinase level, as well as myeloperoxidase activity and the level of thiobarbituric-acid-reactive substances in the gastrocnemius muscle after 24 h. These changes were ameliorated by intake of fermented milk. An increase of CINC-1 was also ameliorated by fermented milk. Furthermore, milk diet increased the mRNA and protein levels of protective proteins such as antioxidants and chaperone proteins. These results indicate that fermented milk can ameliorate delayed-onset muscle damage after prolonged exercise, which is associated with an increased antioxidant capacity of muscles. 相似文献
113.
Maruyama T Yamamoto Y Kano Y Kurazono M Matsuhisa E Takata H Takata T Atsumi K Iwamatsu K Shitara E 《Bioorganic & medicinal chemistry》2007,15(19):6379-6387
A new series of 1beta-methyl carbapenems possessing a 6,7-disubstituted imidazo[5,1-b]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus was prepared, and the activities of these compounds against methicillin-resistant Staphylococcus aureus (MRSA) were evaluated. To study the effect of basic moieties on anti-MRSA activity, we introduced an amino, or imino, or amidino group at the 6-position of imidazo[5,1-b]thiazole in place of the carbamoylmethyl moiety of CP5068. Anti-MRSA activities of almost all basic group-substituted carbapenems were improved, though some of the compounds showed stronger acute toxicity in mice than IPM. In order to decrease the toxicity without decreasing the activity, we introduced various additional functionalities around the basic moiety. Finally, we obtained CP5484, which has excellent anti-MRSA activity and low acute toxicity. 相似文献
114.
Journal of Ethology - Males of the Japanese scorpionfly, Panorpa japonica, often perform male–male competitions for food to offer to females as a nuptial gift. Previous studies have suggested... 相似文献
115.
Journal of Ethology - Circadian rhythm is an important factor for long-distance movement in insect species. Previous studies have shown the relationship between movement and circadian rhythm,... 相似文献
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Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori‐associated Diseases: A Case‐control Study
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Kondo M Sanuki R Ueno S Nishizawa Y Hashimoto N Ohguro H Yamamoto S Machida S Terasaki H Adamus G Furukawa T 《PloS one》2011,6(5):e19911