全文获取类型
收费全文 | 464篇 |
免费 | 42篇 |
专业分类
506篇 |
出版年
2020年 | 4篇 |
2017年 | 5篇 |
2016年 | 6篇 |
2015年 | 5篇 |
2014年 | 10篇 |
2013年 | 21篇 |
2012年 | 18篇 |
2011年 | 21篇 |
2010年 | 9篇 |
2009年 | 13篇 |
2008年 | 9篇 |
2007年 | 12篇 |
2006年 | 14篇 |
2005年 | 12篇 |
2004年 | 17篇 |
2003年 | 7篇 |
2002年 | 18篇 |
2001年 | 12篇 |
2000年 | 7篇 |
1999年 | 12篇 |
1997年 | 4篇 |
1996年 | 5篇 |
1992年 | 5篇 |
1991年 | 11篇 |
1990年 | 12篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1985年 | 8篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1977年 | 11篇 |
1976年 | 5篇 |
1974年 | 7篇 |
1973年 | 8篇 |
1972年 | 7篇 |
1970年 | 6篇 |
1969年 | 5篇 |
1968年 | 4篇 |
1962年 | 4篇 |
1903年 | 7篇 |
1892年 | 4篇 |
1890年 | 9篇 |
1889年 | 5篇 |
1888年 | 5篇 |
1887年 | 7篇 |
排序方式: 共有506条查询结果,搜索用时 0 毫秒
101.
102.
103.
Lawson Tait 《BMJ (Clinical research ed.)》1888,2(1460):1416-1417
104.
105.
MJ Allen K Tait M Mühling K Weynberg C Bradley U Trivedi K Gharbi J Nissimov K Mavromatis CN Jensen G Grogan ST Ali 《Journal of bacteriology》2012,194(17):4753-4754
Stenotrophomonas maltophilia PML168 was isolated from Wembury Beach on the English Coast from a rock pool following growth and selection on agar plates. Here we present the permanent draft genome sequence, which has allowed prediction of function for several genes encoding enzymes relevant to industrial biotechnology, including a novel flavoprotein monooxygenase. 相似文献
106.
Anna L. Koessinger Catherine Cloix Dominik Koessinger Dieter Henrik Heiland Florian J. Bock Karen Strathdee Kevin Kinch Laura Martínez-Escard Nikki R. Paul Colin Nixon Gaurav Malviya Mark R. Jackson Kirsteen J. Campbell Katrina Stevenson Sandeep Davis Yassmin Elmasry Asma Ahmed Jim OPrey Gabriel Ichim Oliver Schnell William Stewart Karen Blyth Kevin M. Ryan Anthony J. Chalmers Jim C. Norman Stephen W. G. Tait 《Cell death and differentiation》2022,29(10):2089
Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour persistence or recurrence. We investigated the therapeutic potential of targeting anti-apoptotic BCL-2 proteins in GBM. Levels of anti-apoptotic BCL-xL and MCL-1 were consistently increased in GBM compared with non-malignant cells and tissue. Moreover, we found that relative to their differentiated counterparts, patient-derived GBM stem-like cells also displayed higher expression of anti-apoptotic BCL-2 family members. High anti-apoptotic BCL-xL and MCL-1 expression correlated with heightened susceptibility of GBM to BCL-2 family protein-targeting BH3-mimetics. This is indicative of increased apoptotic priming. Indeed, GBM displayed an obligate requirement for MCL-1 expression in both tumour development and maintenance. Investigating this apoptotic sensitivity, we found that sequential inhibition of BCL-xL and MCL-1 led to robust anti-tumour responses in vivo, in the absence of overt toxicity. These data demonstrate that BCL-xL and MCL-1 pro-survival function is a fundamental prerequisite for GBM survival that can be therapeutically exploited by BH3-mimetics.Subject terms: Cancer genetics, Cell biology 相似文献
107.
The economic importance of bovine theilerioses has prompted several new approaches to understanding the diseases in the hope of developing more efficient methods of control. Most Theileria species that infect cattle cause a lymphoproli ferative disease. Sporozoites, injected into the host bloodstream by the tick vectors, rapidly invade host lymphocytes and stimulate rapid division of infected cells. As these rupture, merozoites are released which invade red blood cells ready to infect feeding ticks again. The process by which Theileria parasites can control host lymphocytes, and induce them to divide in synchrony with the parasites themselves, is poorly understood but seems to be the key to pathogenesis. In this article, Michael Dyer and Andrew Tait discuss the possible mechanisms of cellular control in the light of recent work revealing sequences homologous to oncogenes in the DNA of T. annulata. 相似文献
108.
109.
Niemi NM Lanning NJ Klomp JA Tait SW Xu Y Dykema KJ Murphy LO Gaither LA Xu HE Furge KA Green DR MacKeigan JP 《Molecular and cellular biology》2011,31(7):1357-1368
Evasion of apoptosis is a significant problem affecting an array of cancers. In order to identify novel regulators of apoptosis, we performed an RNA interference (RNAi) screen against all kinases and phosphatases in the human genome. We identified MK-STYX (STYXL1), a catalytically inactive phosphatase with homology to the mitogen-activated protein kinase (MAPK) phosphatases. Despite this homology, MK-STYX knockdown does not significantly regulate MAPK signaling in response to growth factors or apoptotic stimuli. Rather, RNAi-mediated knockdown of MK-STYX inhibits cells from undergoing apoptosis induced by cellular stressors activating mitochondrion-dependent apoptosis. This MK-STYX phenotype mimics the loss of Bax and Bak, two potent guardians of mitochondrial apoptotic potential. Similar to loss of both Bax and Bak, cells without MK-STYX expression are unable to release cytochrome c. Proapoptotic members of the BCL-2 family (Bax, Bid, and Bim) are unable to trigger cytochrome c release in MK-STYX-depleted cells, placing the apoptotic deficiency at the level of mitochondrial outer membrane permeabilization (MOMP). MK-STYX was found to localize to the mitochondria but is neither released from the mitochondria upon apoptotic stress nor proximal to the machinery currently known to control MOMP, indicating that MK-STYX regulates MOMP using a distinct mechanism. 相似文献
110.