排序方式: 共有147条查询结果,搜索用时 31 毫秒
141.
Ewan M Smith Nour
El
Houda Benbahouche Katherine Morris Ania Wilczynska Sarah Gillen Tobias Schmidt Hedda
A Meijer Rebekah Jukes-Jones Kelvin Cain Carolyn Jones Mark Stoneley Joseph
A Waldron Cameron Bell Bruno
D Fonseca Sarah Blagden Anne
E Willis Martin Bushell 《Nucleic acids research》2021,49(1):458
The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of the protein synthesis machinery. This is achieved, in part, via the co-ordinated regulation of mRNAs that contain a terminal oligopyrimidine tract (TOP) at their 5′ends, although the mechanisms by which this occurs downstream of mTOR signalling are still unclear. We used RNA-binding protein (RBP) capture to identify changes in the protein-RNA interaction landscape following mTOR inhibition. Upon mTOR inhibition, the binding of LARP1 to a number of mRNAs, including TOP-containing mRNAs, increased. Importantly, non-TOP-containing mRNAs bound by LARP1 are in a translationally-repressed state, even under control conditions. The mRNA interactome of the LARP1-associated protein PABPC1 was found to have a high degree of overlap with that of LARP1 and our data show that PABPC1 is required for the association of LARP1 with its specific mRNA targets. Finally, we demonstrate that mRNAs, including those encoding proteins critical for cell growth and survival, are translationally repressed when bound by both LARP1 and PABPC1. 相似文献
142.
Nour El Houda Mimouni Isabel Paiva Anne-Laure Barbotin Fatima Ezzahra Timzoura Damien Plassard Stephanie Le Gras Gaetan Ternier Pascal Pigny Sophie Catteau-Jonard Virginie Simon Vincent Prevot Anne-Laurence Boutillier Paolo Giacobini 《Cell metabolism》2021,33(3):513-530.e8
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143.
Baati Houda Siala Mariem Azri Chafai Ammar Emna Dunlap Christopher Trigui Mohamed 《Extremophiles : life under extreme conditions》2022,26(2):1-10
Extremophiles - We studied the fungal DNA present in a lake sediment core obtained from Trinity Peninsula, Hope Bay, north-eastern Antarctic Peninsula, using metabarcoding through high-throughput... 相似文献
144.
Houda Ilahi Jihed Hsouna Walid Ellouze Takwa Gritli Saif-allah Chihaoui Fathi Barhoumi Mohamed Najib Elfeddy Sarra Bachkouel Lahcen Ouahmane James T. Tambong Bacem Mnasri 《Systematic and applied microbiology》2021,44(4):126221
Nodulated Pisum sativum plants showed the presence of native rhizobia in 16 out of 23 soil samples collected especially in northern and central Tunisia. A total of 130 bacterial strains were selected and three different ribotypes were revealed after PCR-RFLP analysis. Sequence analyses of rrs and four housekeeping genes (recA, atpD, dnaK and glnII) assigned 35 isolates to Rhizobium laguerreae, R. ruizarguesonis, Agrobacterium radiobacter, Ensifer meliloti and two putative genospecies. R. laguerreae was the most dominant species nodulating P. sativum with 63%. The isolates 21PS7 and 21PS15 were assigned to R. ruizarguesonis, and this is the first report of this species in Tunisia. Two putative new lineages were identified, since strains 25PS6, 10PS4 and 12PS15 clustered distinctly from known rhizobia species but within the R. leguminosarum complex (Rlc) with the most closely related species being R. indicum with 96.4% sequence identity. Similarly, strains 16PS2, 3PS9 and 3PS18 showed 97.4% and 97.6% similarity with R. sophorae and R. laguerreae, respectively. Based on 16S-23S intergenic spacer (IGS) fingerprinting, there was no clear association between the strains and their geographic locations. According to nodC and nodA phylogenies, strains of Rlc species and, interestingly, strain 8PS18 identified as E. meliloti, harbored the symbiotic genes of symbiovar viciae and clustered in two different clades showing heterogeneity within the symbiovar. All these strains nodulated and fixed nitrogen with pea plants. However, the strains belonging to A. radiobacter and the two remaining strains of E. meliloti were unable to nodulate P. sativum, suggesting that they were non-symbiotic strains. The results of this study further suggest that the Tunisian Rhizobium community is more diverse than previously reported. 相似文献
145.
Cetin Saatci Ahmet Okay Caglayan Yusuf Ozkul Serpil Tahiri Ahmet Bulent Turhan Munis Dundar 《Cancer epidemiology》2009,33(1):47-50
Background: A plant powder called “Maras powder” is widely used instead of cigarette smoking in the South-Eastern region of Turkey. It has been confirmed that this powder comprises tobacco Nicotiana rustica L. Methods: The aim of this study was to assess the effect of Maras powder and cigarette smoking on the P16 promotor hypermethylation. Twenty-two Maras powder users (Group I), 12 cigarette smokers (Group II), and 16 healthy controls who neither smoked nor used Maras powder (Group III) were included in the study. Hypermethylation of the P16 gene was examined using methylation-specific PCR (MSP) method in the blood of the three groups. Results: Aberrant P16 methylation was found in 7 of the 22 (31.8%) in Group I, in 3 of 12 (25%) in Group II, and in 1 of 16 (6.25%) in Group III. Conclusion: Maras powder may be as harmful as cigarette smoking, leading to hypermethylation in P16 and warrants detailed studies on this subject. 相似文献
146.
Systematic Parasitology - Septitrema lichae n. g., n. sp. (Monogenea: Monocotylidae: Merizocotylinae) is described from the nasal tissue of the deep-sea kitefin shark, Dalatias licha (Bonnaterre)... 相似文献
147.
Min-Wen Ku Maryline Bourgine Pierre Authié Jodie Lopez Kirill Nemirov Fanny Moncoq Amandine Noirat Benjamin Vesin Fabien Nevo Catherine Blanc Philippe Souque Houda Tabbal Emeline Simon David Hardy Marine Le Dudal Françoise Guinet Laurence Fiette Hugo Mouquet Pierre Charneau 《Cell host & microbe》2021,29(2):236-249.e6
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