全文获取类型
收费全文 | 677篇 |
免费 | 37篇 |
出版年
2021年 | 7篇 |
2019年 | 5篇 |
2018年 | 10篇 |
2017年 | 6篇 |
2016年 | 11篇 |
2015年 | 11篇 |
2014年 | 14篇 |
2013年 | 37篇 |
2012年 | 27篇 |
2011年 | 28篇 |
2010年 | 24篇 |
2009年 | 25篇 |
2008年 | 35篇 |
2007年 | 19篇 |
2006年 | 24篇 |
2005年 | 35篇 |
2004年 | 27篇 |
2003年 | 38篇 |
2002年 | 24篇 |
2001年 | 23篇 |
2000年 | 19篇 |
1999年 | 23篇 |
1998年 | 7篇 |
1997年 | 6篇 |
1996年 | 3篇 |
1995年 | 6篇 |
1994年 | 6篇 |
1992年 | 23篇 |
1991年 | 23篇 |
1990年 | 16篇 |
1989年 | 24篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1979年 | 6篇 |
1978年 | 8篇 |
1976年 | 3篇 |
1975年 | 5篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1972年 | 6篇 |
1970年 | 9篇 |
1969年 | 9篇 |
1968年 | 10篇 |
1967年 | 5篇 |
1966年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有714条查询结果,搜索用时 250 毫秒
101.
New serotype 7 of bovine adenovirus 总被引:1,自引:0,他引:1
102.
103.
104.
105.
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: effects on peripheral sensory nerve function,structure and molecular changes
下载免费PDF全文
![点击此处可从《Journal of neurochemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
106.
Yasuo Imanishi Masaaki Inaba Hitoshi Seki Hidenori Koyama Yoshiki Nishizawa Hirotoshi Morii Shuzo Otani 《The Journal of steroid biochemistry and molecular biology》1999,70(4-6)
1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is known to be involved in regulating the proliferation of parathyroid cells and PTH synthesis through reactions involving its nuclear receptor. We evaluated the effects of 1,25-(OH)2D3 and its hexafluorinated analog, 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 (26,27-F6-1,25-(OH)2D3), on parathyroid cells. The 1,25-(OH)2D3 and 26,27-F6-1,25-(OH)2D3 each inhibited [3H]thymidine incorporation and ornithine decarboxylase (ODC) activity, which is important in cell proliferation, in primary cultured bovine parathyroid cells. The inhibitory effect of 26,27-F6-1,25-(OH)2D3 on PTH secretion from parathyroid cells was significantly more potent than that of 1,25-(OH)2D 3 between 10−11 M and 10−8 M. Study of 26,27-F6-1,25-(OH)2D3 metabolism in parathyroid cells in vitro elucidated its slower degradation than that of 1,25-(OH)2D3. After 48 h of incubation with [1β-3H]26,27-F6-1,25-(OH)2D3, two HPLC peaks, one for [1β-3H]26,27-F6-1,25-(OH)2D3, and a second larger peak for [1β-3H]26,27-F6-1,23(S),25-(OH)3D3, were detected. No metabolites were detected after the same period of incubation with 1,25-(OH)2[26,27-3H]D3. We observed that 26,27-F6-1,23(S),25-(OH)3D3 was as potent as 1,25-(OH)2D3 in inhibiting the proliferation of parathyroid cells.Data suggest that the greater biological activity of 26,27-F6-1,25-(OH)2D3 is explained by its slower metabolisms and by the retention of the biological potency of 26,27-F6-1,25-(OH)2D3 even after 23(S)-hydroxylation. 相似文献
107.
108.
109.
In this study, we describe intraspecies variation in the alphaC connector region of the bovine fibrinogen Aalpha gene. Sequencing and genotyping of six bovine breeds revealed 7 to 10 tandem repeats in the alphaC connector region. In addition, we observed length differences between B. indicus and B. taurus, with the B. indicus having longer fibrinogen alphaC connectors (10-repeat alleles) than B. taurus (7- and 9-repeats). The difference in tandem repeats may be related to the function of blood coagulation system. 相似文献
110.
Honda T Tajima H Kaneko Y Ban M Inaba T Takeno Y Okamoto K Aono H 《Bioorganic & medicinal chemistry letters》2008,18(9):2939-2943
We found 4-pyridylmethylthio derivative 1 to be very effective in using antiangiogenesis activity to prevent proliferation of HUVECs (Human Umbilical Vein Endothelial Cells), which was induced by vascular endothelial growth factor (VEGF). Compound 1 was equally effective in inhibiting VEGF receptor2 tyrosine kinase (KDR, IC50 = 26 nM). We deduced that the inhibition was the result of binding the catalytic domain of VEGF receptor2 tyrosine kinase in a similar fashion to both phthalazine derivative PTK787 2 and anthranylamide derivative AAL993 3. In this report, we will describe the conformational analyses, from ab initio MO calculation and X-ray crystallographic analyses, of compound 1 and the analogs, which include non-active 9, all in comparison with 2 and 3. The conformation–activity relationships suggest that a nonbonded intramolecular interaction between the sulfur and the carbonyl oxygen of 1 was very important in inhibiting KDR. 相似文献