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61.
62.
Length‐weight relationships (LWRs) of four freshwater fish species from the Brahmaputra and Barak river basins,northeast India
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S. Basumatary H. Choudhury B. Talukdar D. Sarma 《Zeitschrift fur angewandte Ichthyologie》2018,34(1):208-209
The present study describes the length‐weight relationships (LWRs) were determined for four fish species, collected from the Brahmaputra and Barak river basins in northeast India using cast nets (2.5 × 1 m; 10–15 mm mesh size) and gillnets (30 × 0.9 m; 5–10 mm mesh size), from June 2016 to July 2017. The b values in LWRs were determined as 2.70 for Badis tuivaiei Vishwanath & Shanta, 2004, 2.93 for Canthophrys gongota (Hamilton, 1822), 2.62 for Glyptothorax botius (Hamilton, 1822), and 3.22 for Gogangra viridescens (Hamilton, 1822). 相似文献
63.
Mrinmay Chakrabarti Swapan K. Ray 《Apoptosis : an international journal on programmed cell death》2016,21(3):312-328
Glioblastoma is the deadliest brain tumor in humans. High systemic toxicity of conventional chemotherapies prompted the search for natural compounds for controlling glioblastoma. The natural flavonoids luteolin (LUT) and silibinin (SIL) have anti-tumor activities. LUT inhibits autophagy, cell proliferation, metastasis, and angiogenesis and induces apoptosis; while SIL activates caspase-8 cascades to induce apoptosis. However, synergistic anti-tumor effects of LUT and SIL in glioblastoma remain unknown. Overexpression of tumor suppressor microRNA (miR) could enhance the anti-tumor effects of LUT and SIL. Here, we showed that 20 µM LUT and 50 µM SIL worked synergistically for inhibiting growth of two different human glioblastoma U87MG (wild-type p53) and T98G (mutant p53) cell lines and natural combination therapy was more effective than conventional chemotherapy (10 µM BCNU or 100 µM TMZ). Combination of LUT and SIL caused inhibition of growth of glioblastoma cells due to induction of significant amounts of apoptosis and complete inhibition of invasion and migration. Further, combination of LUT and SIL inhibited rapamycin (RAPA)-induced autophagy, a survival mechanism, with suppression of PKCα and promotion of apoptosis through down regulation of iNOS and significant increase in expression of the tumor suppressor miR-7-1-3p in glioblastoma cells. Our in vivo studies confirmed that overexpression of miR-7-1-3p augmented anti-tumor activities of LUT and SIL in RAPA pre-treated both U87MG and T98G tumors. In conclusion, our results clearly demonstrated that overexpression of miR-7-1-3p augmented the anti-tumor activities of LUT and SIL to inhibit autophagy and induce apoptosis for controlling growth of different human glioblastomas in vivo. 相似文献
64.
Administration of low dose estrogen attenuates persistent inflammation,promotes angiogenesis,and improves locomotor function following chronic spinal cord injury in rats
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65.
Satria P. Sajuthi Neeraj K. Sharma Jeff W. Chou Nicholette D. Palmer David R. McWilliams John Beal Mary E. Comeau Lijun Ma Jorge Calles-Escandon Jamehl Demons Samantha Rogers Kristina Cherry Lata Menon Ethel Kouba Donna Davis Marcie Burris Sara J. Byerly Maggie C. Y. Ng Nisa M. Maruthur Sanjay R. Patel Lawrence F. Bielak Leslie A. Lange Xiuqing Guo Michèle M. Sale Kei Hang K. Chan Keri L. Monda Gary K. Chen Kira Taylor Cameron Palmer Todd L. Edwards Kari E. North Christopher A. Haiman Donald W. Bowden Barry I. Freedman Carl D. Langefeld Swapan K. Das 《Human genetics》2016,135(8):869-880
66.
Kwangwoo Kim So-Young Bang Dae Hyun Yoo Soo-Kyung Cho Chan-Bum Choi Yoon-Kyoung Sung Tae-Hwan Kim Jae-Bum Jun Young Mo Kang Chang-Hee Suh Seung-Cheol Shim Shin-Seok Lee Jisoo Lee Won Tae Chung Seong-Kyu Kim Jung-Yoon Choe Swapan K. Nath Hye-Soon Lee Sang-Cheol Bae 《PloS one》2016,11(2)
The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid level, to better understand disease association with the HLA-DR locus. To this end, we improved an existing HLA reference panel to impute variants in all protein-coding HLA-DR beta genes. Using the reference panel, HLA variants were inferred from high-density SNP data of 9,271 RA-control subjects and 5,342 SLE-control subjects. Disease association tests were performed by logistic regression and log-likelihood ratio tests. After imputation using the newly constructed HLA reference panel and statistical analysis, we observed that HLA-DRB1 variants better accounted for the association between MHC and susceptibility to RA and SLE than did the other three HLA-DRB variants. Moreover, there were no secondary effects in HLA-DRB3, HLA-DRB4, or HLA-DRB5 in RA or SLE. Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE. 相似文献
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M Talukdar A Duarah S Talukdar MB Gohain R Debnath A Yadav DK Jha TC Bora 《World journal of microbiology & biotechnology》2012,28(8):2703-2712
Large number of strains was isolated from soils of Kaziranga National Park of North-East India using selective isolation procedure. They were assigned to the genus Micromonospora on the basis of their typical colonial and pigmentation features. The taxonomic identities of the isolates were confirmed on the basis of their molecular characters (16SrDNA). A total of one hundred Micromonospora strains were isolated during the present investigation. The diagnostic cell wall sugar and amino acids were determined from these Micromonospora strains. After preliminary screening most of the isolates exhibited excellent anti-infective activity against human bacterial pathogens Staphylococcus aureas, Bacillus subtilis, Proteus vulgaris, Echerichia coli, Pseudomonas aeroginosa and fungal pathogens Aspergillus niger, Fusarium oxysporum and Candida albicans. Among these isolates one strain designated as HK-10 showed promising activity against human pathogens S. aureas, B. subtilis, P. vulgaris and P. aeroginosa. 相似文献
70.
Burnham EL McCord JM Bose S Brown LA House R Moss M Gaydos J 《American journal of physiology. Lung cellular and molecular physiology》2012,302(7):L688-L699
Alcohol use disorders (AUDs), including alcohol abuse and dependence, have been linked to the development of acute lung injury (ALI). Prior clinical investigations suggested an association between AUDs and abnormal alveolar epithelial permeability mediated through pulmonary oxidative stress that may partially explain this relationship. We sought to determine if correcting pulmonary oxidative stress in the setting of AUDs would normalize alveolar epithelial permeability in a double-blinded, randomized, placebo-controlled trial of Protandim, a nutraceutical reported to enhance antioxidant activity. We randomized 30 otherwise healthy AUD subjects to receive directly observed inpatient oral therapy with either Protandim (1,350 mg/day) or placebo. Subjects underwent bronchoalveolar lavage (BAL) and blood sampling before study drug administration and after 7 days of therapy; all AUD subjects completed the study protocol without adverse events. BAL total protein was measured at each timepoint as an indicator of alveolar epithelial permeability. In subjects with AUDs, before study drug initiation, BAL total protein values were not significantly higher than in 11 concurrently enrolled controls (P = 0.07). Over the 7-day study period, AUD subjects did not exhibit a significant change in BAL total protein, regardless of their randomization to Protandim {n = 14, -2% [intraquartile range (IQR), -56-146%]} or to placebo [n = 16, 77% (IQR -20-290%); P = 0.19]. Additionally, among those with AUDs, no significant changes in BAL oxidative stress indexes, epithelial growth factor, fibroblast growth factor, interleukin-1β, or interleukin-10 were observed regardless of drug type received. Plasma thiobarbituric acid reactive substances, a marker of lipid peroxidation, decreased significantly over time among AUD subjects randomized to placebo (P < 0.01). These results suggest that Protandim for 7 days in individuals with AUDs who are newly abstinent does not alter alveolar epithelial permeability. However, our work demonstrates the feasibility of safely conducting clinical trials that include serial bronchoscopies in a vulnerable population at risk for acute lung injury. 相似文献