全文获取类型
收费全文 | 296篇 |
免费 | 31篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 7篇 |
2016年 | 11篇 |
2015年 | 21篇 |
2014年 | 16篇 |
2013年 | 15篇 |
2012年 | 25篇 |
2011年 | 25篇 |
2010年 | 24篇 |
2009年 | 15篇 |
2008年 | 11篇 |
2007年 | 7篇 |
2006年 | 10篇 |
2005年 | 13篇 |
2004年 | 10篇 |
2003年 | 14篇 |
2002年 | 14篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1979年 | 1篇 |
1973年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有327条查询结果,搜索用时 31 毫秒
71.
72.
Residential agricultural pesticide exposures and risks of selected birth defects among offspring in the San Joaquin Valley of California
下载免费PDF全文
![点击此处可从《Birth defects research. Part A, Clinical and molecular teratology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
73.
Ashraf F. Zaher Suzan M. Abuel-Maaty Samir A.S. Amer Tamer M. Abdelghany 《Journal of enzyme inhibition and medicinal chemistry》2016,31(6):145-153
AbstractThree series of benzothiophene derivatives were designed and synthesized as cytotoxic agents. The compounds were subjected to in vitro antitumor screening at the National Cancer Institute (NCI), Bethesda, MD. The results of the single dose screening indicated that only the benzothieno[3,2-b]pyran series 3a–f exhibited potent and broad spectrum cytotoxic activity and was subjected to five dose cytotoxic screening. The most active compound in this study was 2-amino-6-bromo-4-(4-nitrophenyl)-4H-[1]benzothieno[3,2-b]pyran-3-carbonitrile (3e) with MG-MID GI50, TGI, and LC50 values of 0.11, 7.94 and 42.66?μM, respectively. Compound 3e exhibited broad spectrum anticancer activity against a panel of 59 cell lines. To elucidate the underlying mechanism of compound 3e cytotoxic activity, we examined its effect on cell cycle progression and its ability to induce apoptosis using human colon adenocarcinoma cell line (HCT-116). The effect of compound 3e on the cell cycle progression indicated that exposure of HCT-116 cells to compound 3e for 24 and 48?h, induced a significant disruption in the cell cycle profile including time dependent decrease in cell population at G1 phase with concomitant increase in pre-G and G2/M cell population. Moreover, compound 3e induced time dependent increase in the percentage of early and late apoptotic and necrotic cell population. In conclusion, we were able to successfully design a new series of benzothieno[3,2-b]pyran derivatives with potent cytotoxic activity and their mechanism of cytotoxicity was examined. 相似文献
74.
Robert M. Smillie Robyn Nott Suzan E. Hetherington Gunnar Öquist 《Physiologia plantarum》1987,69(3):419-428
Smillie, R. M., Nott, R., Hetherington, S. E. and Öyustt, G. 1987. Chilling injury and recovery in detached and attached leaves measured by chlorophyll fluorescence Chilling injury was compared in detached and attached leaves chilled at 0 or 0.5°C by measuring the decrease in induced chlorophyll fluorescence in vivo. The fluorescence parameter measured was FR, the maximal rate of rise of induced chlorophyll fluorescence emission after irradiating dark-adapted leaves. The plants used were bean, Phaseolus vulgaris L. cv. Pioneer, and maize, Zea mays L. cvs hybrid GH 390 and Northern Belle. Leaves were detached and placed on wet paper and covered with thin polyethylene film to prevent water loss during chilling. Leaves left attached on plants were treated similarly. When chilled in this way at 100% relative humidity, the chilling-induced decrease in FR was the same in detached and attached leaves. For the attached leaves, the same result was obtained whether just a single leaf was chilled or the whole plant. Expression of chilling injury was greatest in fully turgid leaves and comparisons can be invalid unless the water status of the detached and attached leaves are the same. Problems arising from diurnal fluctuations in water potential of plants grown in a glasshouse were circumvented by placing leaves on the wet filter paper under polyethylene film prior to chilling, which allowed high water potentials to be regained, or mist sprays in the glasshouse were employed. Determinations of the time course for changes in FR of maize (cv. Northern Belle) during chilling at 0°C showed that FR decreased exponentially, at the same rate (time to 50% decrease in FR was 9.3 h) in detached and attached leaves. Chilling injury was largely reversible for the first 20 h of chilling stress as both detached and attached leaves recovered their pre-chilling values of FR after a further 20 h at 20°C in darkness. Leaves chilled for 48 h showed partial recovery, while those chilled for 72 h did not recover. Recovery was impeded by light. Inability to recover from chilling as indicated by measurements of FR was paralleled by the incidence of visible symptoms of injury. It is concluded that detached and attached leaves behave similarly during chilling and short-term recovery, provided a similarity in treatments is rigorously maintained. 相似文献
75.
Heat tolerance and cold tolerance of cultivated potatoes measured by the chlorophyll-fluorescence method 总被引:1,自引:0,他引:1
Heat and cold tolerances were determined for 13 clones of the commonly cultivated potato, Solanum tuberosum L. Five clones were considered to be adapted to warm climates and the others to cool climates only in terms of their ability to produce tubers. The decrease in the rate of the induced rise in chlorophyll fluorescence after heating leaves at 41°C for 10 min was used to measure relative heat tolerance, and the decrease following chilling at 0°C was used to measure relative cold tolerance. The warm-adapted clones all showed enhanced heat tolerance compared with the cool-adapted clones. Higher heat tolerance was also correlated with a greater tolerance towards a cold stress of 0°C and it is suggested that the warm-adapted clones were selections showing an increased generalized capacity to withstand environmental stresses of several kinds rather than a specific genotypic adaptation to tolerate warm temperatures. Heat and cold tolerances were also determined for several other species of potato cultivated in the Andean region of South America. Of these, S. phureja, which is found at low altitudes on the eastern slopes of the Andes, showed a tolerance to heat comparable to that of the warm-adapted clones of the common potato, the two most heat tolerant of which contained some phureja in their parentage. Diploid and triploid species of cultivated potatoes were considerably more cold tolerant than the clones of the common potato, a tetraploid. The genetic variability for heat and cold tolerance in cultivated and wild potatoes is discussed in relation to increasing the tolerance of the potato to these stresses. 相似文献
76.
Parasitic interaction of Bdellovibrio bacteriovorus with other bacteria 总被引:20,自引:14,他引:6
Starr, Mortimer P. (University of California, Davis), and Nancy L. Baigent. Parasitic interaction of Bdellovibrio bacteriovorus with other bacteria. J. Bacteriol. 91:2006-2017. 1966.-The interactions of the predatory parasite, Bdellovibrio bacteriovorus, with Erwinia amylovora, Pseudomonas tabaci, and P. phaseolicola were examined by means of phase-contrast and electron microscopy. Attachment of the bdellovibrio to the host cell is apparently initially reversible; detachment occurs infrequently in the later stages. Formation of a pore in the host cell wall is followed by disorganization of the host nucleus and of the murein layer of the host cell wall. Short host cells become totally spheroplasted; the longer rods of Pseudomonas usually are partially spheroplasted. The parasite completely invades the host cell, and the cell contents of the host are digested. Bdellovibrios living as parasites inside the host increase considerably in size in comparison with those which have been living away from the host for a time. When the host protoplast is entirely lysed, the parasites leave the disintegrating "ghosted" cell envelope, and are ready to reinitiate the parasitic cycle. The time taken for a mature Bdellovibrio cell to complete the parasitic cycle may vary depending on the length of time the parasite has been away from its hosts. 相似文献
77.
78.
New thelodont scales from the type section of the Khush-Yeilagh Formation, between Shahrud and Shahpasand(Iran), are described. They are provisionally referred to as Skamolepis sp. and Turinia cf. hutkensis. Together with T. hutkensis from South-East Iran and some undescribed scales from the Givetian of Australia, these specimens are some of the youngest thelodont scales known to date, since they are of Lower Eifelian age. 相似文献
79.
80.
Shaw GM Carmichael SL Laurent C Louik C Finnell RH Lammer EJ;National Birth Defects Prevention Study 《Birth defects research. Part A, Clinical and molecular teratology》2007,79(10):708-713
BACKGROUND: There is a paucity of information about risk factors for the human eye anomalies anophthalmia and microphthalmia. In this population-based case-control study we investigated whether periconceptional intakes of supplemental folic acid, dietary folate, vitamin A, and several other nutrients were associated with these eye defects. METHODS: This study included data on deliveries that had estimated due dates from 1997-2002 and were part of the National Birth Defects Prevention Study (the National Birth Defects Prevention Study is a population-based case-control study of a wide spectrum of birth defects, incorporating data from 10 birth defects surveillance systems in the United States [Arkansas, California, Georgia/Centers for Disease Control and Prevention, Iowa, Massachusetts, New Jersey, New York, North Carolina, Texas, and Utah]). Cases were those infants or fetuses born with either anophthalmia or microphthalmia. Liveborn infants without major malformations were eligible as controls. Maternal interviews were conducted, primarily by telephone, in English or Spanish. Participation in the interview was 71% among case mothers and 68% among control mothers. Interviews were completed with 89 case mothers and 4,143 control mothers. A shortened version of the food frequency questionnaire from the Nurse's Health Study was used to assess frequency of intake of 58 food items during the year before pregnancy. RESULTS: Our results did not indicate reduced risks for these eye malformations associated with maternal intake of vitamin supplements containing folic acid. The data did not show an association between malformation risk and higher or lower intakes of vitamin A. We also did not observe strong evidence that an abundance or a lack of dietary intake of any other nutrient was associated with increased risk of the studied eye malformations. CONCLUSIONS: Our observations contribute to a limited body of findings on these rare eye defects. 相似文献