全文获取类型
收费全文 | 265篇 |
免费 | 21篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 11篇 |
2020年 | 8篇 |
2019年 | 10篇 |
2018年 | 8篇 |
2017年 | 5篇 |
2016年 | 11篇 |
2015年 | 14篇 |
2014年 | 20篇 |
2013年 | 29篇 |
2012年 | 31篇 |
2011年 | 30篇 |
2010年 | 14篇 |
2009年 | 17篇 |
2008年 | 14篇 |
2007年 | 10篇 |
2006年 | 10篇 |
2005年 | 5篇 |
2004年 | 8篇 |
2003年 | 7篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有286条查询结果,搜索用时 234 毫秒
191.
192.
Zhao Huanhuan Savin Keith W. Li Yongjun Breen Edmond J. Maharjan Pankaj Tibbits Josquin F. Kant Surya Hayden Matthew J. Daetwyler Hans D. 《Molecular breeding : new strategies in plant improvement》2022,42(4):1-16
Molecular Breeding - Improvement of grain protein content (GPC), loaf volume, and resistance to rusts was achieved in 11 Indian wheat cultivars that are widely grown in four different agro-climatic... 相似文献
193.
194.
Surya Prakash Bhatt Anoop Misra Priyanka Nigam Randeep Guleria M. A. Qadar Pasha 《PloS one》2015,10(11)
Objective
In this study, we have attempted comparison of detailed body composition phenotype of Asian Indians with non-alcoholic fatty liver disease (NAFLD) vs. those without, in a case controlled manner. We also aim to analyse prediction equations for NAFLD for non-diabetic Asian Indians, and compare performance of these with published prediction equations researched from other populations.Methods
In this case-control study, 162 cases and 173 age-and sex-matched controls were recruited. Clinical, anthropometric, metabolic, and body composition profiles, and liver ultrasound were done. Fasting insulin levels, value of homeostasis model assessment of insulin resistance (HOMA-IR), and serum high sensitive C-reactive protein (hs-CRP) levels were evaluated. Multivariate logistic and linear regression analyses were used to arrive at prediction equations for fatty liver [Indian fatty liver index (IFLI)].Results
As compared to those without fatty liver, those with fatty liver exhibited the following; Excess dorsocervical fat (‘Buffalo hump’), skin tags, xanthelasma, ‘double chin’, arcus; excess total, abdominal and subcutaneous adiposity, and high blood pressure, blood glucose, measures of insulin resistance (fasting insulin and HOMA-IR values), lipids and hs-CRP levels. Two prediction equations were developed; Clinical [Indian Fatty Liver Index-Clinical; IFLI-C]: 1(double chin) +15.5 (systolic blood pressure) +13.8 (buffalo hump); and IFLI-Clinical and Biochemical (CB): serum triglycerides+12 (insulin)+1(systolic blood pressure) +18 (buffalo hump). On ROC Curve analysis, IFLI performed better than all published prediction equations, except one.Conclusion
Non-diabetic Asian Indians with NAFLD researched by us were overweight/obese, had excess abdominal and subcutaneous fat, multiple other phenotypic markers, had higher insulin resistance, glycemia, dyslipidemia and subclinical inflammation than those without. Prediction score developed by us for NAFLD; IFLI-C and IFLI-CB, should be useful for clinicians and researchers. 相似文献195.
196.
197.
Surya K. De Vida Chen John L. Stebbins Li-Hsing Chen Jason F. Cellitti Thomas Machleidt Elisa Barile Megan Riel-Mehan Russell Dahl Li Yang Aras Emdadi Ria Murphy Maurizio Pellecchia 《Bioorganic & medicinal chemistry》2010,18(2):590-596
A series of thiadiazole derivatives has been designed as potential allosteric, substrate competitive inhibitors of the protein kinase JNK. We report on the synthesis, characterization and evaluation of a series of compounds that resulted in the identification of potent and selective JNK inhibitors targeting its JIP-1 docking site. 相似文献
198.
Multi stage high rate biomethanation of poultry litter with self mixed anaerobic digester 总被引:1,自引:0,他引:1
A. Gangagni Rao S. Surya PrakashJohny Joseph A. Rajashekhara ReddyP.N. Sarma 《Bioresource technology》2011,102(2):729-735
A multi stage high rate biomethanation process with novel self mixed anaerobic digester (SMAD) was developed in the present study to reduce the hydraulic residence time (HRT), increase the volatile solids (VS) loading rate, improve the VS destruction efficiency and enhance the methane yield. Specific design features of SMAD were useful in mixing the digester contents without consuming power and de-alienated the problem of scum formation. In the first phase, poultry litter having 10% total solids (TS) was subjected to high rate biomethanation in multi stage configuration (SMAD-I and II in series with UASB reactor). It was observed that gross VS reduction of 58%, gross methane yield of 0.16 m3 kg−1 (VS reduced) and VS loading rate of 3.5 kg VS m−3 day−1 at HRT of 13 days was obtained. In the second phase SMAD-II was bypassed from the process scheme keeping the other parameters same as in the first phase. The results obtained were not as encouraging as in the first phase. The study showed that multi stage configuration with SMAD design improved the anaerobic digestion process efficiency of poultry litter. 相似文献
199.
Feng Y Barile E De SK Stebbins JL Cortez A Aza-Blanc P Villanueva J Heryln M Krajewski S Pellecchia M Ronai ZA Chiang GG 《Pigment cell & melanoma research》2011,24(4):703-713
In melanoma, the activation of pro-survival signaling pathways, such as the AKT and NF-κB pathways, is critical for tumor growth. We have recently reported that the AKT inhibitor BI-69A11 causes efficient inhibition of melanoma growth. Here, we show that in addition to its AKT inhibitory activity, BI-69A11 also targets the NF-κB pathway. In melanoma cell lines, BI-69A11 inhibited TNF-α-stimulated IKKα/β and IκB phosphorylation as well as NF-κB reporter gene expression. Furthermore, the effective inhibition of melanoma growth by BI-69A11 was attenuated upon NF-κB activation. Mechanistically, reduced NF-κB signaling by BI-69-A11 is mediated by the inhibition of sphingosine kinase 1, identified in a screen of 315 kinases. Significantly, we demonstrate that BI-69A11 is well tolerated and orally active against UACC 903 and SW1 melanoma xenografts. Our results demonstrate that BI-69A11 inhibits both the AKT and the NF-κB pathways and that the dual targeting of these pathways may be efficacious as a therapeutic strategy in melanoma. 相似文献
200.