全文获取类型
收费全文 | 2236篇 |
免费 | 137篇 |
出版年
2024年 | 7篇 |
2023年 | 20篇 |
2022年 | 32篇 |
2021年 | 59篇 |
2020年 | 29篇 |
2019年 | 42篇 |
2018年 | 61篇 |
2017年 | 49篇 |
2016年 | 68篇 |
2015年 | 104篇 |
2014年 | 101篇 |
2013年 | 154篇 |
2012年 | 185篇 |
2011年 | 158篇 |
2010年 | 113篇 |
2009年 | 96篇 |
2008年 | 154篇 |
2007年 | 136篇 |
2006年 | 117篇 |
2005年 | 120篇 |
2004年 | 85篇 |
2003年 | 75篇 |
2002年 | 87篇 |
2001年 | 31篇 |
2000年 | 24篇 |
1999年 | 23篇 |
1998年 | 32篇 |
1997年 | 16篇 |
1996年 | 13篇 |
1995年 | 14篇 |
1994年 | 8篇 |
1993年 | 9篇 |
1992年 | 13篇 |
1991年 | 14篇 |
1990年 | 12篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 14篇 |
1984年 | 7篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1976年 | 5篇 |
1969年 | 3篇 |
排序方式: 共有2373条查询结果,搜索用时 15 毫秒
971.
972.
Behavioral responses of the small hive beetle,Aethina tumida,to odors of three meliponine bee species and honey bees,Apis mellifera scutellata
下载免费PDF全文
![点击此处可从《Entomologia Experimentalis et Applicata》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Bridget O. Bobadoye Ayuka T. Fombong Nkoba Kiatoko Raina Suresh Peter E. A. Teal Daisy Salifu Baldwyn Torto 《Entomologia Experimentalis et Applicata》2018,166(7):528-534
Recent studies have shown that honey bees, bumble bees, and some meliponine bee species of the genera Trigona, Meliponula, and Dactylurina are hosts of the small hive beetle (SHB) Aethina tumidaMurray (Coleoptera: Nitidulidae), a pest of honey bee colonies in various regions of the world. Olfaction has been implicated in SHB infestations of honey bee and bumble bee colonies. We used olfactometer bioassays to investigate responses of adult male and female SHBs to odors from intact colonies and separate hive components (pot honey, pot pollen, cerumen, and propolis) of three African meliponine bee species, Meliponula ferruginea (Lepeletier) (black morphospecies), M. ferruginea (reddish brown morphospecies), and Meliponula bocandei (Spinola) (Hymenoptera: Apidae). Although both sexes of the beetle strongly preferred intact colony, pot honey, and pot pollen odors, there was no evidence of attraction to propolis and cerumen odors from the three meliponine bee species. Both sexes of SHB also strongly preferred odors from honey bees, Apis mellifera L. (Hymenoptera: Apidae), over odors from the three meliponine bee species. Our results provide substantial evidence of the host potential of African meliponine bees for the SHB, and we discuss this complex association of the SHB with species within the Apidae family. 相似文献
973.
Current study provides information on Length–weight relationship (LWR) of four fish species of family Mugilidae i.e., Planiliza macrolepis (Smith, 1846), Chelon parsia (Hamilton, 1822), Osteomugil cunnesius (Valenciennes, 1836) and Valamugil speigleri (Bleeker, 1858) from Chilika Lagoon, East coast of India. Samples were collected during monsoon (July 2016), winter (November 2016) and summer (April 2017) seasons from the fisher's boats inside the lagoon while fishing with screen barrier nets (mesh size 18‐38 mm) and gill nets (mesh size 34, 38, 46, 62 and 86 mm). The b values were determined from the data set in LWRs as 2.958 for P. macrolepis, 2.952 for O. cunnesius and 2.919 for C. parsia and 2.883 for V. peigleri. In all species, regression values were statistically significant (p < .05). 相似文献
974.
Perera Isiri Subashchandrabose Suresh R. Venkateswarlu Kadiyala Naidu Ravi Megharaj Mallavarapu 《Applied microbiology and biotechnology》2018,102(17):7351-7363
Applied Microbiology and Biotechnology - Desert ecosystem is generally considered as a lifeless habitat with extreme environmental conditions although it is colonized by extremophilic... 相似文献
975.
S. N. Suresh Vijaya Verma Shruthi Sateesh James P. Clement Ravi Manjithaya 《Journal of genetics》2018,97(3):679-701
A proteostasis view of neurodegeneration (ND) identifies protein aggregation as a leading causative reason for damage seen at the cellular and organ levels. While investigative therapies that aim at dissolving aggregates have failed, and the promises of silencing expression of ND associated pathogenic proteins or the deployment of engineered induced pluripotent stem cells (iPSCs) are still in the horizon, emerging literature suggests degrading aggregates through autophagy-related mechanisms hold the current potential for a possible cure. Macroautophagy (hereafter autophagy) is an intracellular degradative pathway where superfluous or unwanted cellular cargoes (such as peroxisomes, mitochondria, ribosomes, intracellular bacteria and misfolded protein aggregates) are wrapped in double membrane vesicles called autophagosomes that eventually fuses with lysosomes for their degradation. The selective branch of autophagy that deals with identification, capture and degradation of protein aggregates is called aggrephagy. Here, we cover the workings of aggrephagy detailing its selectivity towards aggregates. The diverse cellular adaptors that bridge the aggregates with the core autophagy machinery in terms of autophagosome formation are discussed. In ND, essential protein quality control mechanisms fail as the constituent components also find themselves trapped in the aggregates. Thus, although cellular aggrephagy has the potential to be upregulated, its dysfunction further aggravates the pathogenesis. This phenomenon when combined with the fact that neurons can neither dilute out the aggregates by cell division nor the dead neurons can be replaced due to low neurogenesis, makes a compelling case for aggrephagy pathway as a potential therapeutic option. 相似文献
976.
Four Presbytis cristata were treated with oral ivermectin at the same time as the subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0.2 mg/kg monthly and two others given 0.3 mg/kg monthly as well as three control animals became patent for microfilaraemia. However, only 1% of the infective dose was recovered as adult worms from animals in the higher drug dosage group compared to 8.2% and 6.2% in the lower dosage and control groups respectively. 相似文献
977.
Amino acid residues distinct from the determinant region can profoundly affect activation of T cell clones by related antigens 总被引:4,自引:0,他引:4
Hen egg-white lysozyme (HEL)-specific T cell clones derived from the C57BL/6 strain were found to be about 100-fold more sensitive to the closely related ring-necked pheasant lysozyme (REL) in a dose-dependent proliferation assay. This apparent heteroclicity of REL was independent of the fine specificity of the clones. However, when stimulations by corresponding cyanogen bromide-cleaved peptides (L2H and L2R) known to contain the determinants recognized by all of the clones were compared, the preference for REL was lost. Conversely, an HEL-specific, I-Ad-restricted clone that did not respond to REL responded equally well to L2H and to L2R. Because the HEL/REL reactivity differences involved only the T cells and antigen-presenting cells (APC), and were correlated with differential sensitivity to the lysosomotropic drug chloroquine, it appears that the reactivity differences relate to the manner in which lysozymes are processed by the APC. Thus, conclusions about T cell "clonal specificity," usually attributed to differences in recognition of the determinant regions, may in some cases reflect differential antigen handling that depends on sites on the molecule distant from the determinant. 相似文献
978.
Thomas V. Getchell Mary Grillo Suresh S. Tate Reiko Urade John Teeter Dr. Frank L. Margolis 《Neurochemical research》1990,15(4):449-456
We demonstrate that poly (A+)RNA isolated from catfish barbels directs the expression of functional amino acid taste receptors in theXenopus oocyte. The activity of these receptors is monitored in ovo by the two electrode voltage clamp technique. Specific conductance changes recorded in response to amino acid stimulation are analogous to those recorded electrophysiologically from intact catfish barbels. These responses exhibit specificity, reproducibility, rapid onset and termination, and desensitization to repetitive stimulation. A functional assay system that encompasses the full complement of transduction events from the ligand-receptor interaction to subsequent conductance changes is necessary to identify molecular components responsible for these events. Our results demonstrate that theXenopus oocyte can be used to characterize and identify clones coding for amino acid taste receptors analogous to its use in studying receptor molecules for other neuroactive compounds.Special issue is dedicated to Dr. Sidney Udenfriend. 相似文献
979.
Summary The structure and organization of the cytoskeleton in the vegetative cell of germinated pollen grains and pollen tubes ofPyrus communis was examined at the ultrastructural level via chemical fixation and freeze substitution, and at the light microscopic level with the aid of immunofluorescence of tubulin and rhodamine-phalloidin.Results indicate that cortical microtubules and microfilaments, together with the plasma membrane, form a structurally integrated cytoskeletal complex. Axially aligned microtubules are present in cortical and cytoplasmic regions of the pollen grain portion of the cell and the distal region of the pollen tube portion. Cytoplasmic bundles of microfilaments are found in association with elements of endoplasmic reticulum and vacuoles. Axially aligned microfilaments are also found in this region, associated with and independent of the microtubules. Microtubules are lacking in the subapical region where short, axially aligned microfilaments are found in the cell cortex. In the apical region, which also lacks microtubules, a 3-dimensional network of short microfilaments occurs. Microfilaments, but not microtubules, appear to be associated with the vegetative nucleus. 相似文献
980.
N. V. Suresh Kumar 《Journal of molecular modeling》2016,22(6):141
Using B3LYP and B97D functionals of density functional theory (DFT), homochiral and heterochiral cyclic trimerization of imidazole based heterocyclic amino acids are studied in gas phase and solvent phase, i. e., Acetonitrile. Both the functionals show that formation of homochiral cyclic tripeptide is thermodynamically and kinetically favorable over its heterochiral counterpart in gas phase. The functional, B97D, decreases the height of reaction barriers significantly compared to those predicted by the functional B3LYP. The reaction pathways explored using PCM implicit solvent model show reduced kinetic favorability for formation of the homochiral cyclic tripeptide over its heterochiral counterpart. The results are substantiated by structural aspects. 相似文献