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91.
Mohammad Arif Ashraf Achia Khatun Tanzila Sharmin Faraid Mobin Arifur Rahman Tanu Toufique Morshed Tawkir Ahmad Fakir Rifat Ara Begum AHM Nurun Nabi 《Bioinformation》2014,10(6):384-386
The term of medicinal plants include a various types of plants used in herbalism with medicinal activities. These plants are
considered as rich resources of ingredients which can be used as complementary and alternative medicines and, also in drug
developments and synthesis. In addition, some plants regarded as valuable origin of nutrition. Thus, all these plants are
recommended as therapeutic agents. Information related to medicinal plants and herbal drugs accumulated over the ages are
scattered and unstructured which make it prudent to develop a curated database for medicinal plants. MPDB 1.0 database is
dedicated to provide the first window to find the plants around Bangladesh claimed to have medicinal and/or nutritive values by
accumulating data from the published literatures. This database contains 406 medicinal plants with their corresponding scientific,
family and local names as well as utilized parts for treatment from different districts of Bangladesh. Information regarding
ailments is available for 353 plants. In addition, we have found active compounds for 78 plants with their corresponding PubMed
ID.
Availability
www.medicinalplantbd.net 相似文献92.
Kristen L. Lokken Jason P. Mooney Brian P. Butler Mariana N. Xavier Jennifer Y. Chau Nicola Schaltenberg Ramie H. Begum Werner Müller Shirley Luckhart Renée M. Tsolis 《PLoS pathogens》2014,10(5)
Non-typhoidal Salmonella serotypes (NTS) cause a self-limited gastroenteritis in immunocompetent individuals, while children with severe Plasmodium falciparum malaria can develop a life-threatening disseminated infection. This co-infection is a major source of child mortality in sub-Saharan Africa. However, the mechanisms by which malaria contributes to increased risk of NTS bacteremia are incompletely understood. Here, we report that in a mouse co-infection model, malaria parasite infection blunts inflammatory responses to NTS, leading to decreased inflammatory pathology and increased systemic bacterial colonization. Blunting of NTS-induced inflammatory responses required induction of IL-10 by the parasites. In the absence of malaria parasite infection, administration of recombinant IL-10 together with induction of anemia had an additive effect on systemic bacterial colonization. Mice that were conditionally deficient for either myeloid cell IL-10 production or myeloid cell expression of IL-10 receptor were better able to control systemic Salmonella infection, suggesting that phagocytic cells are both producers and targets of malaria parasite-induced IL-10. Thus, IL-10 produced during the immune response to malaria increases susceptibility to disseminated NTS infection by suppressing the ability of myeloid cells, most likely macrophages, to control bacterial infection. 相似文献
93.
Sabira Begum Anjum Ayub Syeda Qamar Zehra Bina Shaheen Siddiqui M. Iqbal Choudhary Samreen 《化学与生物多样性》2014,11(5):709-718
Two new natural triterpenes, lantaninilic acid and lantoic acid, along with the known triterpenes lantadene A, and oleanolic, ursolic, betulinic, lantanolic, and camaric acid, were obtained from the aerial parts of Lantana camara through bioassay‐guided isolation, monitoring the in vitro antileishmanial activity against promastigotes of Leishmania major. Oleanolic acid ( 3 ), ursolic acid ( 4 ), lantadene A ( 5 ), and lantanilic acid ( 7 ) showed significant leishmanicidal activities with IC50 values of 53.0, 12.4, 20.4, and 21.3 μM , respectively. The IC50 value of ursolic acid ( 4 ; 12.4 μM ) was found to be comparable with that of the standard drugs, pentamidine (IC50 15.0 μM ) and amphotericin B (IC50 0.31 μM ). The in vitro activities of L. camara and its constituents against promastigotes of Leishmania major are reported here for the first time. 相似文献
94.
95.
Pelin Cengiz Douglas B. Kintner Vishal Chanana Hui Yuan Erinc Akture Pinar Kendigelen Gulnaz Begum Emin Fidan Kutluay Uluc Peter Ferrazzano Dandan Sun 《PloS one》2014,9(1)
Hypoxia ischemia (HI)-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark of neonatal HI is the development of reactive astrogliosis in the hippocampus. However, the impact of reactive astrogliosis in hippocampal damage after neonatal HI is not fully understood. In the current study, we investigated the role of Na+/H+ exchanger isoform 1 (NHE1) protein in mouse reactive hippocampal astrocyte function in an in vitro ischemia model (oxygen/glucose deprivation and reoxygenation, OGD/REOX). 2 h OGD significantly increased NHE1 protein expression and NHE1-mediated H+ efflux in hippocampal astrocytes. NHE1 activity remained stimulated during 1–5 h REOX and returned to the basal level at 24 h REOX. NHE1 activation in hippocampal astrocytes resulted in intracellular Na+ and Ca2+ overload. The latter was mediated by reversal of Na+/Ca2+ exchange. Hippocampal astrocytes also exhibited a robust release of gliotransmitters (glutamate and pro-inflammatory cytokines IL-6 and TNFα) during 1–24 h REOX. Interestingly, inhibition of NHE1 activity with its potent inhibitor HOE 642 not only reduced Na+ overload but also gliotransmitter release from hippocampal astrocytes. The noncompetitive excitatory amino acid transporter inhibitor TBOA showed a similar effect on blocking the glutamate release. Taken together, we concluded that NHE1 plays an essential role in maintaining H+ homeostasis in hippocampal astrocytes. Over-stimulation of NHE1 activity following in vitro ischemia disrupts Na+ and Ca2+ homeostasis, which reduces Na+-dependent glutamate uptake and promotes release of glutamate and cytokines from reactive astrocytes. Therefore, blocking sustained NHE1 activation in reactive astrocytes may provide neuroprotection following HI. 相似文献
96.
Aneire Ehmar Khan Pauline Franka Denise Scheelbeek Asma Begum Shilpi Queenie Chan Sontosh Kumar Mojumder Atiq Rahman Andy Haines Paolo Vineis 《PloS one》2014,9(9)
Background
Hypertensive disorders in pregnancy are among the leading causes of maternal and perinatal death in low-income countries, but the aetiology remains unclear. We investigated the relationship between salinity in drinking water and the risk of (pre)eclampsia and gestational hypertension in a coastal community.Methods
A population-based case-control study was conducted in Dacope, Bangladesh among 202 pregnant women with (pre)eclampsia or gestational hypertension, enrolled from the community served by the Upazilla Health Complex, Dacope and 1,006 matched controls from the same area. Epidemiological and clinical data were obtained from all participants. Urinary sodium and sodium levels in drinking water were measured. Logistic regression was used to calculate odds ratios, and 95% confidence intervals.Findings
Drinking water sources had exceptionally high sodium levels (mean 516.6 mg/L, S.D 524.2). Women consuming tube-well (groundwater) were at a higher disease risk than rainwater users (p<0.001). Adjusted risks for (pre)eclampsia and gestational hypertension considered together increased in a dose-response manner for increasing sodium concentrations (300.01–600 mg/L, 600.1–900 mg/L, >900.01 mg/L, compared to <300 mg/L) in drinking water (ORs 3.30 [95% CI 2.00–5.51], 4.40 [2.70–7.25] and 5.48 [3.30–9.11] (p-trend<0.001). Significant associations were seen for both (pre)eclampsia and gestational hypertension separately.Interpretation
Salinity in drinking water is associated with increased risk of (pre)eclampsia and gestational hypertension in this population. Given that coastal populations in countries such as Bangladesh are confronted with high salinity exposure, which is predicted to further increase as a result of sea level rise and other environmental influences, it is imperative to develop and evaluate affordable approaches to providing water with low salt content. 相似文献97.
Thermodynamic properties of a Yukawa system consisting of dust particles in plasma are studied in the presence of an external magnetic field. It is assumed that dust particles interact with each other by a modified potential in the presence of a magnetic field. A molecular dynamics code is developed to calculate this internal energy for the entire system. Based on the values of the internal energy given by the code, the Helmholtz free energy and pressure are calculated for the system. 相似文献
98.
99.
Using several model organisms it has been shown earlier that protein designability is related to contact density or fraction
of buried residues and influence protein evolutionary rates dramatically. Here, using Homo sapiens as a model organism, we have analyzed two main folding classes (all-α and all-β) to examine the factors affecting their evolutionary
rates. Since, secondary structures are the most fundamental components of the protein folding classes, we explored the effect
of protein secondary structure composition on evolution. Our results show that sheet and helix fractions exhibit positive
and negative correlations, respectively, with the rate of protein evolution. On dividing the secondary structure components
according to solvent accessibility, linear regression model identified two factors namely buried sheet fraction and relative
aggregation propensity. Both these factors together can explain about 13.4% variability in the rate of human protein evolution, while buried sheet
residues can alone account to 9.9% variability. 相似文献
100.