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排序方式: 共有341条查询结果,搜索用时 31 毫秒
111.
Sunny Manohar Shabana I. Khan Shamseer Kulangara Kandi Kranthi Raj Guojing Sun Xiaochuan Yang Angie D. Calderon Molina Nanting Ni Binghe Wang Diwan S. Rawat 《Bioorganic & medicinal chemistry letters》2013,23(1):112-116
A series of novel monocarbonyl analogues of curcumin have been designed, synthesized and tested for their activity against Molt4, HeLa, PC3, DU145 and KB cancer cell lines. Six of the analogues showed potent cytotoxicity towards these cell lines with IC50 values below 1 μM, which is better than doxorubicin, a US FDA approved drug. Several analogues were also found to be active against both CQ-resistant (W2 clone) and CQ-sensitive (D6) strains of Plasmodium falciparum in an in-vitro antimalarial screening. This level of activity warrants further investigation of the compounds for development as anticancer and antimalarial agents. 相似文献
112.
Kulkarni M Njie-Mbye YF Okpobiri I Zhao M Opere CA Ohia SE 《Neurochemical research》2011,36(8):1540-1545
Hydrogen sulfide (H2S) is a novel gasotransmitter with physiological and pathological functions in vascular homeostasis, cardiovascular system
and central nervous system. In the present study, we determined the endogenous levels of H2S in various tissues of the bovine eye. We also examined the basal levels of H2S in response to donors (sodium hydrosulfide, NaHS and sodium sulfide, Na2S), substrate (l-cysteine), inhibitors (propargylglycine, PAG and aminooxyacetic acid, AOA) and activator (S-adenosyl-l-methionine, SAM) of this gas in the bovine retina. H2S was measured using a well established spectrophotometric method. The highest concentration of endogenous H2S was detected in cornea (19 ± 2.85 nmoles/mg protein, n = 6) and retina (17 ± 2.1 nmoles/mg protein, n = 6). Interestingly, H2S was not present in vitreous humor. The inhibitors of CSE and CBS; PAG (1 mM) and AOA (1 mM), significantly attenuated the
production of H2S in the bovine retina by 56.8 and 42%, respectively. On the other hand the activator of CBS; SAM (100 μM), H2S donors; NaHS (1 μM) and Na2S (100 μM), significantly increased endogenous levels of H2S in bovine retina. l-cysteine (10–300 μM) produced a significant (P < 0.05) concentration-dependent increase in H2S levels reaching a maximal at 300 μM. We conclude that H2S is endogenously produced in various tissues of the isolated bovine eye. Moreover, endogenous levels of H2S are enhanced in the presence of substrate (l-cysteine), an activator of CBS (SAM) and H2S donors but are blocked by inhibitors of enzymes that synthesize this gas in neural retina. 相似文献
113.
Abraham S Hadd MJ Tran L Vickers T Sindac J Milanov ZV Holladay MW Bhagwat SS Hua H Ford Pulido JM Cramer MD Gitnick D James J Dao A Belli B Armstrong RC Treiber DK Liu G 《Bioorganic & medicinal chemistry letters》2011,21(18):5296-5300
The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model. 相似文献
114.
Xiao Sun Yingzhi Liu Ziheng Huang Wenye Xu Wei Hu Lina Yi Zhe Liu Hung Chan Judeng Zeng Xiaodong Liu Huarong Chen Jun Yu Francis Ka Leung Chan Siew Chien Ng Sunny Hei Wong Maggie Haitian Wang Tony Gin Gavin Matthew Joynt David Shu Cheong Hui Xuan Zou Yuelong Shu Christopher Hon Ki Cheng Shisong Fang Huanle Luo Jing Lu Matthew Tak Vai Chan Lin Zhang William Ka Kei Wu 《Cell death and differentiation》2022,29(6):1240
115.
Xiaoting Chen Hung Chan Lin Zhang Xiaodong Liu Idy H. T. Ho Xiang Zhang Jeffery Ho Wei Hu Yuanyuan Tian Shanglong Kou Chee Sam Chan Jun Yu Sunny H. Wong Tony Gin Matthew T. V. Chan Xuegang Sun William K. K. Wu 《Journal of cellular and molecular medicine》2019,23(6):4290-4300
Impaired autophagic degradation of intracellular lipids is causally linked to the development of non‐alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein, we investigated the effects of polydatin, a natural precursor of resveratrol, in a murine nutritional model of NASH and a cell line model of steatosis. Results showed that oral administration of polydatin protected against hepatic lipid accumulation and alleviated inflammation and hepatocyte damage in db/db mice fed methionine‐choline deficient diet. Polydatin also alleviated palmitic acid‐induced lipid accumulation in cultured hepatocytes. In both models, polydatin restored lysosomal function and autophagic flux that were impaired by NASH or steatosis. Mechanistically, polydatin inhibited mTOR signalling and up‐regulated the expression and activity of TFEB, a known master regulator of lysosomal function. In conclusion, polydatin ameliorated NASH through restoring autophagic flux. The polydatin‐regulated autophagy was associated with inhibition of mTOR pathway and restoration of lysosomal function by TFEB. Our study provided affirmative preclinical evidence to inform future clinical trials for examining the potential anti‐NASH effect of polydatin in humans. 相似文献
116.
We hypothesized that C-reactive protein (CRP) may affect the cell cycle and induce apoptotic changes of monocytes. CRP (∼25 μg/ml) significantly increased expressions of B-cell translocation gene 2 (BTG2) mRNA and protein in human monocytes through pathways involving CD32/NADPH oxidase 2/p53, which eventually induced G2/M phase arrest and apoptotic cell death. Such pro-apoptotic effect of CRP was not found in thioglycollate-elicited intraperitoneal monocytes/macrophages harvested from BTG2-knockout male C57BL/6 mice (n = 5). Within atheromatous plaques obtained from CRP-transgenic male LDLR−/− C57BL/6 mice (n = 5) and human coronary arteries, BTG2 co-localized with CRP, p53 and monocytes/macrophages. Therefore the pro-apoptotic pathway of CRP-CD32-Nox2-p53-BTG2 may contribute to the retardation of the atherogenic process. 相似文献
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119.
Nardus Mollentze Louis H. Nel Sunny Townsend Kevin le Roux Katie Hampson Daniel T. Haydon Samuel Soubeyrand 《Proceedings. Biological sciences / The Royal Society》2014,281(1782)
We describe a statistical framework for reconstructing the sequence of transmission events between observed cases of an endemic infectious disease using genetic, temporal and spatial information. Previous approaches to reconstructing transmission trees have assumed all infections in the study area originated from a single introduction and that a large fraction of cases were observed. There are as yet no approaches appropriate for endemic situations in which a disease is already well established in a host population and in which there may be multiple origins of infection, or that can enumerate unobserved infections missing from the sample. Our proposed framework addresses these shortcomings, enabling reconstruction of partially observed transmission trees and estimating the number of cases missing from the sample. Analyses of simulated datasets show the method to be accurate in identifying direct transmissions, while introductions and transmissions via one or more unsampled intermediate cases could be identified at high to moderate levels of case detection. When applied to partial genome sequences of rabies virus sampled from an endemic region of South Africa, our method reveals several distinct transmission cycles with little contact between them, and direct transmission over long distances suggesting significant anthropogenic influence in the movement of infected dogs. 相似文献
120.