全文获取类型
收费全文 | 290篇 |
免费 | 13篇 |
出版年
2021年 | 14篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 10篇 |
2014年 | 11篇 |
2013年 | 20篇 |
2012年 | 10篇 |
2011年 | 17篇 |
2010年 | 16篇 |
2009年 | 4篇 |
2008年 | 14篇 |
2007年 | 18篇 |
2006年 | 11篇 |
2005年 | 14篇 |
2004年 | 10篇 |
2003年 | 9篇 |
2002年 | 5篇 |
2001年 | 6篇 |
2000年 | 4篇 |
1999年 | 3篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 3篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 6篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 3篇 |
1966年 | 2篇 |
1965年 | 2篇 |
1964年 | 1篇 |
1962年 | 1篇 |
1960年 | 1篇 |
1954年 | 1篇 |
1952年 | 1篇 |
排序方式: 共有303条查询结果,搜索用时 0 毫秒
61.
Two novel triterpenes belonging to swertane skeleton, besides gammacer-16-en-3β-ol and 21αH-hop- 22(29)-en-3β-ol, of rare occurrence have been isolated from Swertia chirata, along with some common triterpenoids. Their structures were established on the basis of spectral and chemical evidence. 相似文献
62.
Joseph K. Agyin Bindu Santhamma Sudipa S. Roy 《Bioorganic & medicinal chemistry letters》2013,23(23):6455-6458
Multiple myeloma (MM) is an incurable neoplasm characterized by devastating and progressive bone destruction. Standard chemotherapeutic agents have not been effective at significantly prolonging the survival of MM patients and these agents are typically associated with often severe, dose-limiting side effects. There is great need for methods to target the delivery of novel, effective cytotoxic agents specifically to bone, where myeloma cells reside. We have synthesized and evaluated the effects of the bone-targeted proteasome inhibitors PS-341-BP-1, PS-341-BP-2 and MG-262-BP on cell proliferation using the mouse 5TGM1 and human RPMI 8226 cell lines in vitro. The compounds exhibit strong cytotoxicity on MM cell lines and reduce the number of viable cells in a dose dependent manner. 相似文献
63.
64.
K Chakravarty P Leahy D Becard P Hakimi M Foretz P Ferre F Foufelle R W Hanson 《The Journal of biological chemistry》2001,276(37):34816-34823
65.
66.
Barawkar DA Bandyopadhyay A Deshpande A Koul S Kandalkar S Patil P Khose G Vyas S Mone M Bhosale S Singh U De S Meru A Gundu J Chugh A Palle VP Mookhtiar KA Vacca JP Chakravarty PK Nargund RP Wright SD Roy S Graziano MP Cully D Cai TQ Singh SB 《Bioorganic & medicinal chemistry letters》2012,22(13):4341-4347
Long chain L-2-hydroxy acid oxidase 2 (Hao2) is a peroxisomal enzyme expressed in the kidney and the liver. Hao2 was identified as a candidate gene for blood pressure (BP) quantitative trait locus (QTL) but the identity of its physiological substrate and its role in vivo remains largely unknown. To define a pharmacological role of this gene product, we report the development of selective inhibitors of Hao2. We identified pyrazole carboxylic acid hits 1 and 2 from screening of a compound library. Lead optimization of these hits led to the discovery of 15-XV and 15-XXXII as potent and selective inhibitors of rat Hao2. This report details the structure activity relationship of the pyrazole carboxylic acids as specific inhibitors of Hao2. 相似文献
67.
Saha A Gomes A Giri B Chakravarty AK Biswas AK Dasgupta SC Gomes A 《Indian journal of experimental biology》2006,44(4):279-285
Pathophysiology due to snakebite is a combined effect of various actions of the complex venom constituents. Importance of protein toxins in snake envenomation is well known. The present investigation reports the existence of nonprotein/nonpetide low molecular weight toxin in Indian King Cobra venom, which plays an important role in envenomation consequences in experimental animal models. A group of non-peptidic toxins (OH-NPT1) was isolated from Indian King Cobra Ophiophagus hannah by thin layer chromatography and silica gel column chromatography. UV, IR, NMR and (ESI) TOF-MS studies characterized the OH-NPT1 as a mixture of aliphatic acids having molecular weights 256, 326 and 340Da. The minimum lethal dose of OH-NPT1 was found to be 2.5 microg/20g (iv) and 4microg/20g (ip) in male albino mice. The cardiotoxic property of OH-NPT1 was established through studies on isolated guinea pig heart and auricle preparations, ECG studies in albino rat and estimation of LDH1/LDH and CPK-MB/CPK ratio in Swiss albino mice. Commercial antiserum failed to neutralize the lethality and cardiotoxicity of the toxin. However, calcium and magnesium effectively neutralized the lethal action. 相似文献
68.
69.
Jonathan M Carlson Arijit Chakravarty Radhika S Khetani Robert H Gross 《BMC bioinformatics》2006,7(1):254-17
Background
The identification of statistically overrepresented sequences in the upstream regions of coregulated genes should theoretically permit the identification of potential cis-regulatory elements. However, in practice many cis-regulatory elements are highly degenerate, precluding the use of an exhaustive word-counting strategy for their identification. While numerous methods exist for inferring base distributions using a position weight matrix, recent studies suggest that the independence assumptions inherent in the model, as well as the inability to reach a global optimum, limit this approach. 相似文献70.
The whole seed extract of S. nux vomica (in low doses) effectively neutralized Daboia russelii venom induced lethal, haemorrhage, defibrinogenating, PLA2 enzyme activity and Naja kaouthia venom induced lethal, cardiotoxic, neurotoxic, PLA2 enzyme activity. The seed extract potentiated polyvalent snake venom antiserum action in experimental animals. An active compound (SNVNF) was isolated and purified by thin layer chromatography and silica gel column chromatography, which effectively antagonised D. russelii venom induced lethal, haemorrhagic, defibrinogenating, oedema, PLA2 enzyme activity and N. kaouthia induced lethal, cardiotoxic, neurotoxic, PLA, enzyme activity. Polyvalent snake venom antiserum action was significantly potentiated by the active compound. Spectral studies revealed it to be a small, straight chain compound containing methyl and amide radicals. Detailed structure elucidation of the compound (SNVNF) is warranted before its clinical trials as a snake venom antagonist. 相似文献