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121.
The 29-kilodalton thiol-dependent peroxidase of Entamoeba histolytica is a factor involved in pathogenesis and survival of the parasite during oxidative stress
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The 29-kDa surface antigen (thiol-dependent peroxidase; Eh29) of Entamoeba histolytica exhibits peroxidative and protective antioxidant activities. During tissue invasion, the trophozoites are exposed to oxidative stress and need to deal with highly toxic reactive oxygen species (ROS). In this investigation, attempts have been made to understand the role of the 29-kDa peroxidase gene in parasite survival and pathogenesis. Inhibition of eh29 gene expression by antisense RNA technology has shown approximately 55% inhibition in eh29 expression, maximum ROS accumulation, and significantly lower viability in 29-kDa downregulated trophozoites during oxidative stress. The cytopathic and cytotoxic activities were also found to decrease effectively in the 29-kDa downregulated trophozoites. Size of liver abscesses was substantially lower in hamsters inoculated with 29-kDa downregulated trophozoites compared to the normal HM1:IMSS. These findings clearly suggest that the 29-kDa protein of E. histolytica has a role in both survival of trophozoites in the presence of ROS and pathogenesis of amoebiasis. 相似文献
122.
Stress fiber growth and remodeling determines cellular morphomechanics under uniaxial cyclic stretch
Chatterjee Aritra Kondaiah Paturu Gundiah Namrata 《Biomechanics and modeling in mechanobiology》2022,21(2):553-567
Biomechanics and Modeling in Mechanobiology - Stress fibers in the cytoskeleton are essential in maintaining cellular shape and influence cellular adhesion and migration. Cyclic uniaxial stretching... 相似文献
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Josette Zaklit Indira Chatterjee Normand Leblanc Gale L. Craviso 《生物化学与生物物理学报:生物膜》2019,1861(6):1180-1188
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Wen Yen Li Dhruba J. Chatterjee Bhasker V. Shetty Ellen Y. Wu Franco Muggia Robert T. Koda 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1995,673(2)
AG 331 is a novel thymidylate synthase inhibitor currently in Phase I clinical trial. To determine the pharmacokinetic parameters of AG 331 in human subjects, a suitable analytical method was developed using high-performance liquid chromatography. Serum and urine samples were prepared using both solid-phase extraction and solvent extraction. Either 4,4′-diaminodiphenyl sulfone or benz[cd]indole-2(1H)-one were used as internal standards for the method. A reversed-phase C18 analytical column completely resolved the drug and internal standard peaks from non-specific substances present in biological matrix. The method was validated for precision, accuracy, and reproducibility in serum and was linear over a concentration range of 50–2000 ng/ml, with a limit of detection of 20.0 ng/ml and a quantifiable limit of 50 ng/ml. 相似文献
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Habib AA Chatterjee S Park SK Ratan RR Lefebvre S Vartanian T 《The Journal of biological chemistry》2001,276(12):8865-8874
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Vitamin D and genomic stability 总被引:7,自引:0,他引:7
Chatterjee M 《Mutation research》2001,475(1-2):69-87
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