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91.
The lipocalin Xlcpl1 expressed in the neural plate of Xenopus laevis embryos is a secreted retinaldehyde binding protein. 总被引:1,自引:1,他引:0 下载免费PDF全文
G. Lepperdinger B. Strobl A. Jilek A. Weber J. Thalhamer H. Flckner C. Mollay 《Protein science : a publication of the Protein Society》1996,5(7):1250-1260
The cellular and structural properties and binding capabilities of a lipocalin expressed in the early neural plate of Xenopus laevis embryos and the adult choroid plexus have been investigated. It was found that this lipocalin, termed Xlcpl1, binds retinal at a nanomolar concentration, retinoic acid in the micromolar range, but does not show binding to retinol. Furthermore, this protein also binds D/L thyroxine. The Xlcpl1 cDNA was expressed in cell culture using the vaccinia virus expression system. In AtT20 cells, Xlcpl1 was secreted via the constitutive secretory pathway. We therefore assume that cpl1 binds retinaldehyde during the transport through the compartments of the secretory pathway that are considered to be the storage compartments of retinoids. Therefore, cpl1-expressing cells will secrete the precursors of active retinoids such as retinoic acid isomers. These retinoids may enter the cytosol by diffusion or receptor-controlled mechanisms, as has been shown for exogenously applied retinoids. Based on these data, it is suggested that cpl1 is an integral member of the retinoid signaling pathway and, therefore, it plays a key role in pattern formation in early embryonic development. 相似文献
92.
A role for DNA methylation in vertebrate gene expression? 总被引:1,自引:0,他引:1
J S Strobl 《Molecular endocrinology (Baltimore, Md.)》1990,4(2):181-183
93.
Prof. P. Gabriel Strobl 《Plant Systematics and Evolution》1884,34(8):293-297
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94.
Prof. P. Gabriel Strobl 《Plant Systematics and Evolution》1886,36(7):237-240
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95.
Prof. P. Gabriel Strobl 《Plant Systematics and Evolution》1884,34(10):368-371
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96.
P. Gabriel Strobl 《Plant Systematics and Evolution》1874,24(1):27-30
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97.
Prof. P. Gabriel Strobl 《Plant Systematics and Evolution》1884,34(12):435-440
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98.
Prof. P. Gabriel Strobl 《Plant Systematics and Evolution》1884,34(3):101-104
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99.
Raimund M. Vielnascher Eva Hainzl Nicole R. Leitner Michael Rammerstorfer David Popp Agnieszka Witalisz Rita Rom Marina Karaghiosoff Thomas Kolbe Simone Müller Thomas Rülicke Caroline Lassnig Birgit Strobl Mathias Müller 《Transgenic research》2014,23(3):519-529
Tyrosine kinase 2 (TYK2) has a pivotal role in immunity to infection and tumor surveillance. It is associated with several cytokine receptor chains including type I interferon (IFN) receptor 1 (IFNAR1), interleukin- (IL-) 12 receptor beta 1 (IL-12Rb1) and IL-10R2. We have generated a mouse with a conditional Tyk2 null allele and proved integrity of the conditional Tyk2 locus. TYK2 was successfully removed by the use of ubiquitous and tissue-specific Cre-expressing mouse strains. Myeloid TYK2 was found to critically contribute to the defense against murine cytomegalovirus. Ubiquitous TYK2 ablation severely impaired tumor immunosurveillance, while deletion in myeloid, dendritic or T cells alone showed no effect. The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer. 相似文献
100.
BC Wilson D Burnett R Rappaport LJ Parry EK Fletcher 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》2009,153(1):69-74
Relaxins are peptides similar in secondary structure to insulins. In teleost genomes, five or six relaxin genes have been identified. Two relaxins group closely with mammalian relaxin-3 on phylogenetic analysis and are named relaxin-3a and b. We refer to the remainder as relaxins c to f. Ovarian expression of relaxin-3a, d and f genes, and the relaxin-3 receptor gene Rxfp3, was studied in Danio rerio using RT-PCR. Immunohistochemistry was used to determine the distribution of relaxin-3 peptides and RXFP3 in the ovary of Fundulus heteroclitus (killifish). Thirdly, enzyme immunoassays and ovarian follicular culture were used to determine the effect of treatment with human recombinant relaxin-3 on the production of 17beta-estradiol and 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one in killifish ovarian follicles. Relaxin-3a, d, f, and Rxfp3 genes were expressed regardless of sex or reproductive condition. Relaxin-3 immunostaining was present in mid to late follicular stages within cortical alveoli of the oocyte cytopasm, whereas receptor staining was localized to follicular cells. Treatment with relaxin-3 enhanced 17beta-estradiol production in early and late maturing follicles, but did not have an effect in vitellogenic follicles. Relaxin-3 appeared to suppress the release of MIS production. This suggests that relaxin peptides may be involved with estradiol-dependant events in follicular development. 相似文献