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排序方式: 共有173条查询结果,搜索用时 15 毫秒
101.
102.
Ventilation of liquid by the fetal lamb during asphyxia 总被引:2,自引:0,他引:2
103.
J Strang 《BMJ (Clinical research ed.)》1991,303(6809):1043-1046
104.
105.
Lauren RH Krumpe Kathryn M Schumacher James B McMahon Lee Makowski Toshiyuki Mori 《BMC biotechnology》2007,7(1):65
Background
Amino acid sequence diversity is introduced into a phage-displayed peptide library by randomizing library oligonucleotide DNA. We recently evaluated the diversity of peptide libraries displayed on T7 lytic phage and M13 filamentous phage and showed that T7 phage can display a more diverse amino acid sequence repertoire due to differing processes of viral morphogenesis. 相似文献106.
Aart C. Strang Menno L. W. Knetsch Leo H. Koole Robbert J. de Winter Allard C. van der Wal Carlie J. M. de Vries Paul P. Tak Radjesh J. Bisoendial Erik S. G. Stroes Joris I. Rotmans 《PloS one》2015,10(3)
Background and Aims
Since high-density lipoprotein (HDL) has pro-endothelial and anti-thrombotic effects, a HDL recruiting stent may prevent restenosis. In the present study we address the functional characteristics of an apolipoprotein A-I (ApoA-I) antibody coating in vitro. Subsequently, we tested its biological performance applied on stents in vivo in rabbits.Materials and Methods
The impact of anti ApoA-I- versus apoB-antibody coated stainless steel discs were evaluated in vitro for endothelial cell adhesion, thrombin generation and platelet adhesion. In vivo, response to injury in the iliac artery of New Zealand white rabbits was used as read out comparing apoA-I-coated versus bare metal stents.Results
ApoA-I antibody coated metal discs showed increased endothelial cell adhesion and proliferation and decreased thrombin generation and platelet adhesion, compared to control discs. In vivo, no difference was observed between ApoA-I and BMS stents in lumen stenosis (23.3±13.8% versus 23.3±11.3%, p=0.77) or intima surface area (0.81±0.62 mm2 vs 0.84±0.55 mm2, p=0.85). Immunohistochemistry also revealed no differences in cell proliferation, fibrin deposition, inflammation and endothelialization.Conclusion
ApoA-I antibody coating has potent pro-endothelial and anti-thrombotic effects in vitro, but failed to enhance stent performance in a balloon injury rabbit model in vivo. 相似文献107.
Dafydd R. Owen David J. Bull Mark E. Bunnage Melanie S. Glossop Robert J. Maguire Ross S. Strang 《Bioorganic & medicinal chemistry letters》2010,20(1):92-96
A suitable inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) has the potential to be a novel treatment for thrombosis. The TAFIa inhibitor UK-396082 (1) was used as a starting point to seek more potent analogues. With knowledge of encouraging human pharmacokinetics and toleration for the clinical candidate (1), the programme continued to seek structure–activity relationships (SAR) that could positively impact on both potency and half-life, and therefore the projected dose of any future nominated clinical agent. A series of oxygenated analogues based on compound 1 were prepared to evaluate changes in pharmacology, selectivity and pharmacokinetics. 相似文献
108.
Glossop MS Bazin RJ Dack KN Fox DN MacDonald GA Mills M Owen DR Phillips C Reeves KA Ringer TJ Strang RS Watson CA 《Bioorganic & medicinal chemistry letters》2011,21(11):3404-3406
Heteroarylalanine derivatives 4 were designed as potential inhibitors of neutral endopeptidase (NEP EC 3.4.24.11). Selectivity over other zinc metalloproteinases was explored through occupation of the S2′ subsite within NEP. Structural optimisation led to the identification of 5-phenyl oxazole 4f, a potent and selective NEP inhibitor. A crystal structure of the inhibitor bound complex is reported. 相似文献
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110.
Locusts and cockroaches were subjected to stress by poisoning with various insecticides, and by enforced walking. Chromatographic analysis of the dansyl derivatives of the amino compounds in the haemolymph and nervous tissue revealed that taurine more than doubled in concentration. Other amino acids showed changes in concentration, generally of a lower statistical significance. Electrophysiological tests on isolated nerve cords showed that taurine had an inhibitory effect on the spontaneous activity. This effect was found with concentrations occurring in vivo, and was proportional to concentration. 相似文献