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Building strong relationships between conservation genetics and primary industry leads to mutually beneficial genomic advances
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Stephanie J. Galla Thomas R. Buckley Rob Elshire Marie L. Hale Michael Knapp John McCallum Roger Moraga Anna W. Santure Phillip Wilcox Tammy E. Steeves 《Molecular ecology》2016,25(21):5267-5281
Several reviews in the past decade have heralded the benefits of embracing high‐throughput sequencing technologies to inform conservation policy and the management of threatened species, but few have offered practical advice on how to expedite the transition from conservation genetics to conservation genomics. Here, we argue that an effective and efficient way to navigate this transition is to capitalize on emerging synergies between conservation genetics and primary industry (e.g., agriculture, fisheries, forestry and horticulture). Here, we demonstrate how building strong relationships between conservation geneticists and primary industry scientists is leading to mutually‐beneficial outcomes for both disciplines. Based on our collective experience as collaborative New Zealand‐based scientists, we also provide insight for forging these cross‐sector relationships. 相似文献
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Wiebke Garrels Ayan Mukherjee Stephanie Holler Nicole Cleve Thirumala R. Talluri Brigitte Barg-Kues Mike Diederich Peter Köhler Björn Petersen Andrea Lucas-Hahn Heiner Niemann Zsuzsanna Izsvák Zoltán Ivics Wilfried A. Kues 《Transgenic research》2016,25(1):63-70
Recently, we established the Sleeping Beauty transposon system for germ line competent transgenesis in the pig. Here, we extend this approach to re-target a transposon-tagged locus for a site-specific gene knock-in, and generated a syngeneic cohort of piglets carrying either the original transposon or the re-targeted event. A Cre-loxP-mediated cassette exchange of the tagging transposon with a different reporter gene was performed, followed by flow cytometric sorting and somatic cell nuclear transfer of recombined cells. In parallel, the original cells were employed in somatic cell nuclear transfer to generate clone siblings, thereby resulting in a clone cohort of piglets carrying different reporter transposons at an identical chromosomal location. Importantly, this strategy supersedes the need for an antibiotic selection marker. This approach expands the arsenal of genome engineering technologies in domestic animals, and will facilitate the development of large animal models for human diseases. Potentially, the syngeneic cohort of pigs will be instrumental for vital tracking of transplanted cells in pre-clinical assessments of novel cell therapies. 相似文献
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Maya L. Groner Luke A. Rogers Andrew W. Bateman Brendan M. Connors L. Neil Frazer Sean C. Godwin Martin Krko?ek Mark A. Lewis Stephanie J. Peacock Erin E. Rees Crawford W. Revie Ulrike E. Schl?gel 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2016,371(1689)
Effective disease management can benefit from mathematical models that identify drivers of epidemiological change and guide decision-making. This is well illustrated in the host–parasite system of sea lice and salmon, which has been modelled extensively due to the economic costs associated with sea louse infections on salmon farms and the conservation concerns associated with sea louse infections on wild salmon. Consequently, a rich modelling literature devoted to sea louse and salmon epidemiology has been developed. We provide a synthesis of the mathematical and statistical models that have been used to study the epidemiology of sea lice and salmon. These studies span both conceptual and tactical models to quantify the effects of infections on host populations and communities, describe and predict patterns of transmission and dispersal, and guide evidence-based management of wild and farmed salmon. As aquaculture production continues to increase, advances made in modelling sea louse and salmon epidemiology should inform the sustainable management of marine resources. 相似文献
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Aeryun Kim Stephanie L. Servetas Jieun Kang Jinmoon Kim Sungil Jang Yun Hui Choi Hanfu Su Yeong-Eui Jeon Youngmin A. Hong Yun-Jung Yoo D. Scott Merrell Jeong-Heon Cha 《Journal of microbiology (Seoul, Korea)》2016,54(12):846-852
The array of outer membrane proteins (OMPs) found in Helicobacter pylori provides a crucial component for persistent colonization within the gastric niche. Not only does H. pylori harbor a wide number of OMPs, but these OMPs often vary across strains; this likely contributes to immune evasion, adaptation during long term colonization, and potentially differential disease progression. Previous work from our group described OMP differences among the Bab family (babA, babB, and babC) and Hom family (homA and homB) from 80 American H. pylori clinical isolates (AH) and 80 South Korean H. pylori clinical isolates (KH). In the current study, we expanded our investigation to include the less well characterized Hom family member, HomC. 相似文献
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