排序方式: 共有95条查询结果,搜索用时 0 毫秒
91.
Sylvaine Giakoumi François Guilhaumon Salit Kark Antonio Terlizzi Joachim Claudet Serena Felline Carlo Cerrano Marta Coll Roberto Danovaro Simonetta Fraschetti Drosos Koutsoubas Jean‐Batiste Ledoux Tessa Mazor Bastien Mérigot Fiorenza Micheli Stelios Katsanevakis 《Diversity & distributions》2016,22(12):1220-1231
92.
Stelios F. Assimakopoulos Dimitris Konstantinou Christos Georgiou Elisabeth Chroni 《Amino acids》2010,38(3):973-974
In a recently published article in “Amino Acids” it was shown that obstructive jaundice of 9 days’ duration in rats induces
significant alterations of polyamines’ metabolism in the brain, which might play an important pathogenetic role in cholestatic
brain injury. The authors proposed that alterations of polyamines in cholestatic brain might induce neuronal toxicity through
a mechanism that implicates the production of reactive oxygen species and oxidative stress, although this parameter was not
evaluated in their study. This hypothesis is supported by our recent findings on brain oxidative status in rats with obstructive
jaundice of 10 days’ duration. Potential interrelations of the two studies’ findings are discussed in this commentary. 相似文献
93.
Achilleas Savva Foteini Petraki Polyvios Elefteriou Lambrini Sygellou Monika Voigt Myrsini Giannouli Stella Kennou Jenny Nelson Donal D. C. Bradley Christoph J. Brabec Stelios A. Choulis 《Liver Transplantation》2013,3(3):391-398
We study the origin of the improvement of the power conversion efficiency (PCE) of inverted organic solar cells when an interfacial insulating organic layer of polyoxyethylene tridecyl ether (PTE) is introduced between the indium tin oxide (ITO) bottom electrode and the TiOx interfacial layer. XPS and UPS measurements are used to investigate the energy level alignment at the interfaces within the ITO/TiOx and ITO/PTE/TiOx structures and to identify any effects due to chemical interaction and interfacial dipoles. Scanning electron microscopy studies show that the surface structure of the TiOx layer is affected, when it is coated on top of the PTE layer. Surface contact angle measurements show that the incorporated interfacial layer of PTE is more hydrophilic than ITO and thus PTE modified TiOx becomes more hydrophilic. This, in combination with the surface gaps of the PTE interfacial layer, is likely to lead to changed wetting and hydrolysis properties of TiOx when coated on ITO/PTE than on ITO alone. The different TiOx layer quality is reflected in improved electron selectivity, leading to enhanced fill factor, reduced parasitic resistance effects and higher power conversion efficiency for inverted solar cells with a PTE interfacial layer between ITO and TiOx. 相似文献
94.
Nika Rajabian Debanik Choudhury Izuagie Ikhapoh Shilpashree Saha Aishwarya S. Kalyankar Pihu Mehrotra Aref Shahini Kendall Breed Stelios T. Andreadis 《Aging cell》2023,22(3):e13764
Cellular senescence leads to the depletion of myogenic progenitors and decreased regenerative capacity. We show that the small molecule 2,6-disubstituted purine, reversine, can improve some well-known hallmarks of cellular aging in senescent myoblast cells. Reversine reactivated autophagy and insulin signaling pathway via upregulation of Adenosine Monophosphate-activated protein kinase (AMPK) and Akt2, restoring insulin sensitivity and glucose uptake in senescent cells. Reversine also restored the loss of connectivity of glycolysis to the TCA cycle, thus restoring dysfunctional mitochondria and the impaired myogenic differentiation potential of senescent myoblasts. Altogether, our data suggest that cellular senescence can be reversed by treatment with a single small molecule without employing genetic reprogramming technologies. 相似文献
95.
Caroline Goujon Rebecca A. Greenbury Stelios Papaioannou Tomas Doyle Michael H. Malim 《Journal of virology》2015,89(8):4676-4680
We have employed molecular genetic approaches to understand the domain organization of the HIV-1 resistance factor myxovirus resistance 2 (MX2). First, we describe an essential triple-arginine motif in the amino-terminal domain. Second, we demonstrate that this 91-residue domain mediates antiviral activity when appended to heterologous proteins, and we provide genetic evidence that protein oligomerization is required for MX2 function. These insights will facilitate future work aiming to elucidate MX2''s mechanism of action. 相似文献