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951.
Khokhlova VN Karelin AA Belotserkovskiĭ MV Stetsiuk OU 《Antibiotiki i khimioterapii͡a》2011,56(5-6):19-29
The data on the microbiological investigation of clinical materials from patients with complicated skin and soft tissue infections in 6 European countries were analysed. The analysis of the bacterial pathogens spectrum provided the microbial view and efficient use of novel antimicrobials in clinical trials. 相似文献
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Svetoch EA Borzilov AI Eruslanov BV Korobova OV Kombarova TI Levchuk VP Teĭmurazov MG Stepanshin IuG Marinin LI Diatlov IA 《Antibiotiki i khimioterapii͡a》2011,56(9-10):13-18
The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B. anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections. 相似文献
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Gotovtseva VIu Grammatikova NÉ Bibikova MV Katlinskiĭ AV 《Antibiotiki i khimioterapii͡a》2011,56(7-8):3-6
Natural complex compounds with hipolipidemic activity, having considerable inhibitory effect on expression of bacteria virulence factors were isolated. Inhibitory properties of the compounds with respect to pyocyanine and protease formation, as well as their influence on the quorum sensing mechanism in Chromobacterium violacium were shown. 相似文献
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Ponomareva AA Rykova EIu Cherdyntseva NV Choĭnzonov EL Laktionov PP Vlasov VV 《Molekuliarnaia biologiia》2011,45(2):203-217
The major approaches to different lung cancer marker development are outlined in the review, including genetic, epigenetic, protein, transcryptomic, proteomic, metabolic, and miRNA markers. As far as epigenetic changes are among the earliest events in malignant transformation, methylated markers are thoroughly discussed. Special attention is given to minimally invasive tumor markers, which could be detected in easily accessible biological fluids, because they can be useful for screening and early diagnostics of cancer (before its clinical manifestation) as well as for verification of standard methods of diagnostics. Extracellular nucleic acids, circulating in blood (cirNA), are highlighted as the potential source of material for the early lung cancer diagnostics, prediction of antitumor treatment efficiency, post-treatment monitoring and disease prognosis. 相似文献