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HAROLD St. JOHN F.L.S. 《Biological journal of the Linnean Society. Linnean Society of London》1972,4(4):305-310
Sydney Parkinson, aged 18, was Sir Joseph Banks' private assistant and artist on Captain Cook's first voyage around the world. Parkinson died on the voyage. Among his effects delivered to his brother Stanfield were drawings and notes which the latter published as a journal. Included in it is a chapter on the economic plants of Tahiti, and most of them are given scientific names, some of which were new. In 1941 Fosberg adopted two of them to form names which were new combinations under Artocarpus , and Inocarpus . The writer now indicates that Parkinson's names of 1773 were mononomials, hence invalid, but that in the German edition of 1774, edited by Herr "Z", the names are valid binomials. For the two plants mentioned, the authorship of the combinations is revised. 相似文献
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Jonas G. Barlind Linda K. Buckett Sharon G. Crosby Öjvind Davidsson Hans Emtenäs Anne Ertan Ulrik Jurva Malin Lemurell Pablo Morentin Gutierrez Karolina Nilsson Gavin O’Mahony Annika U. Petersson Alma Redzic Fredrik Wågberg Zhong-Qing Yuan 《Bioorganic & medicinal chemistry letters》2013,23(9):2721-2726
[Acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome. In this Letter we report our discovery and optimisation of a novel series of MGAT2 inhibitors. The development of the SAR of the series and a detailed discussion around some key parameters monitored and addressed during the lead generation phase will be given. The in vivo results from an oral lipid tolerance test (OLTT) using the MGAT2 inhibitor (S)-10, shows a significant reduction (68% inhibition relative to na?ve, p <0.01) in plasma triacylglycerol (TAG) concentration. 相似文献
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Dan Cog?lniceanu Laurentiu Rozylowicz Paul Székely Ciprian Samoil? Florina St?nescu Marian Tudor Diana Székely Ruben Iosif 《ZooKeys》2013,(341):49-76
The reptile fauna of Romania comprises 23 species, out of which 12 species reach here the limit of their geographic range. We compiled and updated a national database of the reptile species occurrences from a variety of sources including our own field surveys, personal communication from specialists, museum collections and the scientific literature. The occurrence records were georeferenced and stored in a geodatabase for additional analysis of their spatial patterns. The spatial analysis revealed a biased sampling effort concentrated in various protected areas, and deficient in the vast agricultural areas of the southern part of Romania. The patterns of species richness showed a higher number of species in the warmer and drier regions, and a relatively low number of species in the rest of the country. Our database provides a starting point for further analyses, and represents a reliable tool for drafting conservation plans. 相似文献
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Sylvie Cablé Michèle Kedinger Michel Dauça 《Differentiation; research in biological diversity》1993,54(2):99-108
Abstract. The development of peroxisomes and expression of their enzymes were investigated in differentiating intestinal epithelial cells during their migration along the crypt-villus axis. Sequential cell populations harvested by a low-temperature method were identified by microscopy, determination of alkaline phosphatase and sucrase activities and incorporation of [3 H]-thymidine into DNA. Ultrastructural cytochemistry after staining for catalase activity, revealed the presence of peroxisomes in undifferentiated stem cells located in the crypt region. Morphometry indicated that the number of these organelles increased as intestinal epithelial cells differentiate. Catalase activity was higher in the crypt cells than in the mature enterocytes harvested from villus tips. On the other hand, an increasing gradient of activity was observed from crypts to villus tips for peroxisomal oxidases, i.e. fatty acyl coA oxidase, D-amino acid oxidase and polyamine oxidase. These findings indicate that biogenesis of peroxisomes occurs during migration of intestinal epithelial cells along the crypt-villus axis and that peroxisomal oxidases contribute substantially to the biochemical maturation of enterocytes. 相似文献
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