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Rajasekaran Ekambaram Akila Kannaiyan Vijayasarathy Marimuthu Vinobha Chinnaiah Swaminathan Senthil Renganathan Ananda Gopu Perumal 《Bioinformation》2014,10(3):138-143
Spatial arrangement of carbon in protein structure is analyzed here. Particularly, the carbon fractions around individual atoms arecompared. It is hoped that it follows the principle of 31.45% carbon around individual atoms. The results reveal that globularprotein''s atoms follow this principle. A comparative study on monomer versus dimer reveal that carbon is better distributed indimeric form than in its monomeric form. Similar study on solid versus liquid structures reveals that the liquid (NMR) structurehas better carbon distribution over the corresponding solid (X-Ray) structure. The carbon fraction distributions in fiber and toxinprotein are compared. Fiber proteins follow the principle of carbon fraction distribution. At the same time it has another broadspectrum of carbon distribution than in globular proteins. The toxin protein follows an abnormal carbon fraction distribution. Thecarbon fraction distribution plays an important role in deciding the structure and shape of proteins. It is hoped to help inunderstanding the protein folding and function. 相似文献
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Srividya S Roy RP Basu SK Mukhopadhyay A 《Biochemical and biophysical research communications》2000,268(3):772-777
We have shown that muramyl dipeptide (MDP) conjugated to a 10-mer polyguanylic acid (PolyG) is specifically internalized by macrophages through scavenger receptor (SCR)-mediated endocytosis. Macrophages activated by PolyG-MDP displayed about 20-fold higher cytotoxic activity against nonmacrophage tumor cells compared to that elicited by free MDP. The PolyG-MDP was found to trigger the secretion of higher levels of interleukin-6, interleukin-1alpha, TNF-alpha, and nitric oxide in comparison to free MDP. Addition of antibodies directed against IL-6 and TNF-alpha to macrophage culture completely abrogated the tumoricidal response of PolyG-MDP, indicating that these two cytokines are primarily responsible for bioefficacy. This general approach of PolyG as a vehicle may find wide application in the delivery of genes and antisense oligonucleotides to macrophages. 相似文献
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Kesavan PC Swaminathan MS 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2008,363(1492):877-891
The green revolution of the 1960s and 1970s which resulted in dramatic yield increases in the developing Asian countries is now showing signs of fatigue in productivity gains. Intensive agriculture practiced without adherence to the scientific principles and ecological aspects has led to loss of soil health, and depletion of freshwater resources and agrobiodiversity. With progressive diversion of arable land for non-agricultural purposes, the challenge of feeding the growing population without, at the same time, annexing more forestland and depleting the rest of life is indeed daunting. Further, even with food availability through production/procurement, millions of marginal farming, fishing and landless rural families have very low or no access to food due to lack of income-generating livelihoods. Approximately 200 million rural women, children and men in India alone fall in this category. Under these circumstances, the evergreen revolution (pro-nature, pro-poor, pro-women and pro-employment/livelihood oriented ecoagriculture) under varied terms are proposed for achieving productivity in perpetuity. In the proposed 'biovillage paradigm', eco-friendly agriculture is promoted along with on- and non-farm eco-enterprises based on sustainable management of natural resources. Concurrently, the modern ICT-based village knowledge centres provide time- and locale-specific, demand-driven information needed for evergreen revolution and ecotechnologies. With a system of 'farm and marine production by masses', the twin goals of ecoagriculture and eco-livelihoods are addressed. The principles, strategies and models of these are briefly discussed in this paper. 相似文献
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Beena E. Thomas Puneet K. Dewan Sophia Vijay Aleyamma Thomas Lakhdir Singh Chauhan Chandrasekaran Vedachalam Preetish Vaidyanathan Soumya Swaminathan 《PloS one》2009,4(12)