排序方式: 共有138条查询结果,搜索用时 171 毫秒
71.
Ole A. Andreassen Wesley K. Thompson Andrew J. Schork Stephan Ripke Morten Mattingsdal John R. Kelsoe Kenneth S. Kendler Michael C. O'Donovan Dan Rujescu Thomas Werge Pamela Sklar The Psychiatric Genomics Consortium Bipolar Disorder Schizophrenia Working Groups J. Cooper Roddey Chi-Hua Chen Linda McEvoy Rahul S. Desikan Srdjan Djurovic Anders M. Dale 《PLoS genetics》2015,11(11)
72.
Biljana Nikolić Mihailo Ristić Srdjan Bojović Zoran Krivošej Vlado Matevski Petar D. Marin 《化学与生物多样性》2015,12(2):295-308
The needle‐terpene profiles of two natural Pinus heldreichii populations from Mts. O?ljak and Gali?ica (Scardo‐Pindic mountain system) were analyzed. Among the 68 detected compounds, 66 were identified. The dominant constituents were germacrene D (28.7%), limonene (27.1%), and α‐pinene (16.2%). β‐Caryophyllene (6.9%), β‐pinene (5.2%), β‐myrcene (2.3%), pimaric acid (2.0%), α‐humulene (1.2%), and seven additional components were found to be present in medium‐to‐high amounts (0.5–10%). Although the general needle‐terpene profile of the population from Gali?ica was similar to those of the populations from Lov?en, Zeletin, Bjelasica, and Zlatibor‐Pe?ter (belonging to the Dinaric Alps), the principle‐component analysis (PCA) of seven terpenes (β‐myrcene, limonene, β‐elemene, β‐caryophyllene, α‐humulene, δ‐cadinene, and germacrene D‐4‐ol) in 121 tree samples suggested a partial divergence in the needle‐terpene profiles between the populations from the Scardo‐Pindic mountain system and the Dinaric Alps. According to previously reported data, the P. heldreichii samples from the Balkan‐Rhodope mountains lack β‐caryophyllene and germacrene D, but contain γ‐muurolene in their terpene profile. Differences in the terpene composition between populations growing in the three above‐mentioned mountain systems were compared and discussed. 相似文献
73.
74.
GPS-free Positioning in Mobile Ad Hoc Networks 总被引:30,自引:0,他引:30
We consider the problem of node positioning in ad hoc networks. We propose a distributed, infrastructure-free positioning algorithm that does not rely on GPS (Global Positioning System). Instead, the algorithm uses the distances between the nodes to build a relative coordinate system in which the node positions are computed in two dimensions. Despite the distance measurement errors and the motion of the nodes, the algorithm provides sufficient location information and accuracy to support basic network functions. Examples of applications where this algorithm can be used include Location Aided Routing [10] and Geodesic Packet Forwarding [2]. Another example are sensor networks, where mobility is less of a problem. The main contribution of this work is to define and compute relative positions of the nodes in an ad hoc network without using GPS. We further explain how the proposed approach can be applied to wide area ad hoc networks. 相似文献
75.
In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs 总被引:3,自引:0,他引:3
The aim of this study was to investigate antimicrobial properties of ethanolic extract of 13 propolis (EEP) samples from different regions of Serbia against 39 microorganisms (14 resistant or multiresistant to antibiotics), and to determine synergistic activity between antimicrobials and propolis. Antimicrobial activity of propolis samples was evaluated by agar diffusion and agar dilution method. The synergistic action of propolis with antimicrobial drugs was assayed by the disc diffusion method on agar containing subinhibitory concentrations of propolis. Obtained results indicate that EEP, irrespectively of microbial resistance to antibiotics, showed significant antimicrobial activities against Gram-positive bacteria (MIC 0.078%–1.25% of EEP) and yeasts (0.16%–1.25%), while Gram-negative bacteria were less susceptible (1.25&%ndash;>5%). Enterococcus faecalis was the most resistant Gram-positive bacterium, Salmonella spp. the most resistant Gram-negative bacteria, and Candida albicans the most resistant yeast. EEP showed synergism with selected antibiotics, and displayed ability to enhance the activities of antifungals. The shown antimicrobial potential of propolis alone or in combination with certain antibiotics and antifungals is of potential medical interest. 相似文献
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77.
Acta Biotheoretica - Some contemporary theorists such as Mazzocchi, Theise and Kafatos are convinced that the reformed complementarity may redefine how we might exploit the complexity theory in... 相似文献
78.
Ravindra S. Telang Vinthiya Paramananthasivam Srdjan M. Vlajkovic David J. B. Munoz Gary D. Housley Peter R. Thorne 《Purinergic signalling》2010,6(2):263-272
Extracellular adenosine triphosphate (ATP) has profound effects on the cochlea, including an effect on the regulation of the
endocochlear potential (EP). Noise-induced release of ATP into the endolymph activates a shunt conductance mediated by P2X2 receptors in tissues lining the endolymphatic compartment, which reduces the EP and, consequentially, hearing sensitivity.
This may be a mechanism of adaptation or protection from high sound levels. As inaction of such a process could contribute
to hearing loss, this study examined whether the action of ATP on EP changes with age and noise exposure in the mouse. The
EP and the endolymphatic compartment resistance (CoPR) were measured in mice (CBA/CaJ) aged between 3 and 15 months. The EP
and CoPR declined slightly with age with an associated small, but significant, reduction in auditory brainstem response thresholds.
ATP (100–1,000 μM) microinjected into the endolymphatic compartment caused a dose-dependent decline in EP correlated to a
similar decrease in CoPR. This was blocked by pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonate, consistent with a P2X2 receptor-mediated shunt conductance. There was no substantial difference in the ATP response with age. Noise exposure (octave-band
noise 80–100 decibels sound pressure level (dBSPL), 48 h) in young animals induced an upregulation of the P2X2 receptor expression in the organ of Corti and spiral limbus, most noticeably with the 90-dB exposure. This did not occur
in the aged animals except following exposure at 90 dBSPL. The EP response to ATP was muted in the noise-exposed aged animals
except following the 90-dB exposure. These findings provide some evidence that the adaptive response of the cochlea to noise
may be reduced in older animals, and it is speculated that this could increase their susceptibility to noise-induced injury. 相似文献
79.
Simó Graells Srdjan Aćimović Giorgio Volpe Romain Quidant 《Plasmonics (Norwell, Mass.)》2010,5(2):135-139
Electron beam induced deposition (EBID) is used to grow on a transparent substrate plasmonic antennas formed by gold nanorods.
We first discuss the influence of the growth parameters on the geometrical homogeneity of the structures. The optical response
of optimized rods with different aspect ratios are measured using scattering spectroscopy. The optical data show antenna resonances
in good agreement with 3D numerical simulations for pure gold antennas, validating EBID as a novel relevant technique for
the fabrication of plasmonic nanostructures. 相似文献
80.
Mary G. O’Keeffe Peter R. Thorne Gary D. Housley Simon C. Robson Srdjan M. Vlajkovic 《Histochemistry and cell biology》2010,133(4):425-436
Ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) regulate complex extracellular P2 receptor signalling pathways
in mammalian tissues by hydrolysing extracellular nucleotides to the respective nucleosides. All enzymes from this family
(NTPDase1-8) are expressed in the adult rat cochlea. This study reports the changes in expression of NTPDase5 and NTPDase6
in the developing rat cochlea. These two intracellular members of the E-NTPDase family can be released in a soluble form and
show preference for nucleoside 5′-diphosphates, such as UDP and GDP. Here, we demonstrate differential spatial and temporal
patterns for NTPDase5 and NTPDase6 expression during cochlear development, which are indicative of both cytosolic and extracellular
action via pyrimidines. NTPDase5 is noted during the early postnatal period in developing sensory hair cells and supporting
Deiters’ cells of the organ of Corti, and primary auditory neurons located in the spiral ganglion. In contrast, NTPDase6 is
confined to the embryonic and early postnatal hair cell bundles. NTPDase6 immunolocalisation in the developing cochlea underpins
its putative role in hair cell bundle development, probably via cytosolic action, whilst NTPDase5 may have a broader extracellular
role in the development of sensory and neural tissues in the rat cochlea. Both NTPDase5 and NTPDase6 colocalize with UDP-preferring
P2Y4, P2Y6 and P2Y14 receptors during cochlear development, but this strong association was lost in the adult cochlea. Spatiotemporal topographic
expression of NTPDase5 and NTPDase6 and P2Y receptors in adult and developing cochlear tissues provide strong support for
the role of pyrimidinergic signalling in cochlear development. 相似文献