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221.
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Nicholas E. Grossoehme Anne M. Spuches Dean E. Wilcox 《Journal of biological inorganic chemistry》2010,15(8):1183-1191
The thermodynamics of metals ions binding to proteins and other biological molecules can be measured with isothermal titration
calorimetry (ITC), which quantifies the binding enthalpy (ΔH°) and generates a binding isotherm. A fit of the isotherm provides the binding constant (K), thereby allowing the free energy (ΔG°) and ultimately the entropy (ΔS°) of binding to be determined. The temperature dependence of ΔH° can then provide the change in heat capacity (ΔC
p°) upon binding. However, ITC measurements of metal binding can be compromised by undesired reactions (e.g., precipitation,
hydrolysis, and redox), and generally involve competing equilibria with the buffer and protons, which contribute to the experimental
values (K
ITC, ΔH
ITC). Guidelines and factors that need to be considered for ITC measurements involving metal ions are outlined. A general analysis
of the experimental ITC values that accounts for the contributions of metal–buffer speciation and proton competition and provides
condition-independent thermodynamic values (K, ΔH°) for metal binding is developed and validated. 相似文献
223.
224.
Background
Pelodera (Rhabditis) strongyloides is a small saprophytic nematode that lives in decaying organic matter. On rare occasions, it can invade the mammalian skin, causing a pruritic, erythematous, alopecic and crusting dermatitis on skin sites that come into contact with the ground. Diagnosis of the disease is based on case history (a dog living outdoors on damp straw bedding) with characteristic skin lesions and on the demonstration of typical larvae in skin scrapings or biopsy. Pelodera (rhabditic) dermatitis cases have been reported mainly from Central European countries and the United States. 相似文献225.
Bases and spaces: resources on the web for accessing the draft human genome - II - After publication of the draft
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Colin AM Semple 《Genome biology》2001,2(6):reviews2001.1-reviews20016
The volume of human genome sequence and the variety of web-based tools to access it continue to grow at an impressive rate, but a working knowledge of certain key resources can be sufficient to get the most from your genome. This article provides an update to Genome Biology 2000, 1(4):reviews2001.1-2001.5. 相似文献