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41.
A V Spirov 《Izvestiia Akademii nauk SSSR. Seriia biologicheskaia》1992,(5):699-709
Hypothesis is developed about mechanisms of determination of limb bud of mammals as a result of expression of homeo box containing genes (hox genes) of known up to date four hox families. Spatial pattern of the expression plays a role of coordinate system for subsequent processes of morphogenesis and differentiation of the limbs. Propositions of the hypothesis are realized in a computer dynamic model. The results of modeling are compared with known data on features of the expression of hox genes in the mesenchyme of developing limb buds in mammals and birds. 相似文献
42.
A V Bocharov I B Fedina V G Spirov N A Bochkova A A Shnyra 《Biulleten' eksperimental'no? biologii i meditsiny》1990,109(6):590-592
The ability of hepatocytes cultured on Biosilon microcarriers to secrete albumin and to conjugate bilirubin were examined for the purpose of developing an artificial liver support system. Cultured hepatocytes were able to synthesize 100-120 micrograms albumin per 10(5) cells in 24 hours and to conjugate about 20 micrograms/hr of bilirubin for at least 5 days. Rats with liver failure caused by i.p. injection of CCL4 or D-galactosamine were subjected to hemosorption via minicolumns containing 2 ml of Biosilon microcarriers with 40 X 10(6) cultured hepatocytes. The procedure was performed 20-24 h after hepatotoxins injection and lasted for 3 h at a flow rate of 60 ml/h. This reduced mortality from 100% to 20% after 48% and to 40% after 7 days in case of CCl4 and from 100% to 40% after 48 h and 7 days in case of D-galactosamine. Our results suggest that hepatocytes cultured on microcarriers may be efficiently applied to correction of fulminant hepatic failure caused by different hepatotoxins. 相似文献
43.
Miriam R Faria Mara S Hoshida Eloisa AV Ferro Francesca Ietta Luana Paulesu Estela Bevilacqua 《Reproductive biology and endocrinology : RB&E》2010,8(1):95
Background
Macrophage migration inhibitory factor (MIF) has special pro-inflammatory roles, affecting the functions of macrophages and lymphocytes and counter-regulating the effects of glucocorticoids on the immune response. The conspicuous expression of MIF during human implantation and early embryonic development also suggests this factor acts in reproductive functions. The overall goal of this study was to evaluate Mif expression by trophoblast and embryo placental cells during mouse pregnancy. 相似文献44.
T G Vishniakova A A Shnyra A V Bocharov V G Spirov O V Smirnova 《Biokhimii?a (Moscow, Russia)》1989,54(4):694-701
Male rat hepatocyte cultures have been obtained. The culturing hepatocytes had a stable level of some morphological and functional properties. A high level of estrogen receptors (ER) and E2-sensitive unusual estrogen-binding protein (UEBP) was found. A direct dose-dependent inhibiting effect of physiological (10(-10)-10(-7) M) concentrations of E2 on UEBP content was established in cell cultures incubated with the hormone for 3 days. Hexestrol (but not cholesterol) was found to exert a direct inhibiting effect. The inhibiting effect of E2 (10(-9) M) was observed after a 24 hour incubation of hepatocytes with the hormone but was less pronounced. In this case a significant increase in UEBP concentration in hepatocytes was noted 72 hours after the removal of E2. It is concluded that physiological concentrations of E2 can exert a direct regulatory influence on certain functions of culturing hepatocytes acting via hepatocyte ER. 相似文献
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