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11.
AV. H. HEWOOD EDITAE 《Botanical journal of the Linnean Society. Linnean Society of London》1979,78(3):235-236
Following the publication of the last of the series of Flora Europaea Notulae, No. 20 in the Botanical Journal of the Linnean Society , 76: 297–384 (1978), a number of additions or alterations have been drawn to our attention. These are published in continuation. 相似文献
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Molecular Biology - The ensemble of gap genes is one of the best studied and most conserved gene regulatory networks (GRNs). Gap genes, such as hunchback (hb), Krüppel (Kr), pou-domain (pdm;... 相似文献
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Spirov A. V. Levchenko V. F. Sabirov M. A. Grigorev I. P. Korzhevskii D. E. Evsyukova I. I. Lunichkin A. M. Zhukovskaya M. I. Gorshkova O. P. Silkin Yu. A. Silkina E. N. Silkin M. Yu. Ravaeva M. Yu. Chuyan E. N. Cheretaev I. V. Mironyuk I. S. Grishina T. V. Pushchina E. V. Kapustyanov I. A. Shamshurina E. V. Varaksin A. A. Fedorova I. M. Tikhonov D. B. Prutskova N. P. Seliverstova E. V. Hernandez-Cortes P. Ünüvar S. Gürsoy Ş. Berk A. Kaymaz B. İlhan N. Aktay G. El-Kafoury B. M. A. Saad R. A. Ismail E. G. M. Abdel-Hady E. A. Lobov G. I. Ivanova G. T. Plekanchuk V. S. Ryazanova M. A. Pogorelova T. N. Gunko V. O. Nikashina A. A. Alliluev I. A. 《Journal of Evolutionary Biochemistry and Physiology》2021,57(2):424-428
Journal of Evolutionary Biochemistry and Physiology - A Correction to this paper has been published: https://doi.org/10.1134/S0022093021020216 相似文献
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V. D. Selemir V. A. Demidov V. F. Ermolovich G. M. Spirov P. B. Repin I. V. Pikulin A. A. Volkov A. P. Orlov A. S. Boriskin O. M. Tatsenko A. N. Moiseenko M. A. Barinov I. M. Markevtsev S. A. Kazakov V. T. Selyavskiĭ E. V. Shapovalov B. P. Giterman Yu. V. Vlasov P. S. Dydykin E. A. Ryaslov D. V. Kotel’nikov S. V. Gaĭdash 《Plasma Physics Reports》2007,33(5):381-390
Results are presented from experiments on the implosion of wire arrays powered from 100-and 200-mm-diameter helical explosive magnetocumulative generators with explosive opening switches. The experiments were performed at load currents of up to 4 MA, the current rise time being 0.3–0.4 μs. The maximum soft X-ray yield of ~ 100 kJ was achieved at a pinch plasma temperature of 55 eV. A two-dimensional MHD code was developed to simulate the process of liner implosion and the generation of X-ray emission. The results of computer simulations agree satisfactorily with the experimental data. 相似文献
16.
The role of Bicoid cooperative binding in the patterning of sharp borders in Drosophila melanogaster
In Drosophila embryonic development, the Bicoid (Bcd) protein establishes positional information of downstream developmental genes like hunchback (hb), which has a strong anterior expression and a sharp on-off boundary in the mid-embryo. The role of Bcd cooperative binding in the positioning of the Hb pattern has been previously demonstrated. However, there are discrepancies in the reported results about the role of this mechanism in the sharp Hb border. Here, we determined the Hill coefficient (n(H)) required for Bcd to generate the sharp border of Hb in wild-type (WT) embryos. We found that an n(H) of approximately 6.3 (s.d. 1.4) and 10.8 (s.d. 4.0) is required to account for Hb sharpness at early and late cycle 14A, respectively. Additional mechanisms are possibly required because the high n(H) is likely unachievable for Bcd binding to the hb promoter. To test this idea, we determined the n(H) required to pattern the Hb profile of 15 embryos expressing an hb(14F) allele that is defective in self-activation and found n(H) to be 3.0 (s.d. 1.0). This result indicates that in WT embryos, the hb self-activation is important for Hb sharpness. Corroborating our results, we also found a progressive increase in the required value of n(H) spanning from 4.0 to 9.2 by determining this coefficient from averaged profiles of eight temporal classes at cycle 14A (T1 to T8). Our results indicate that there is a transition in the mechanisms responsible for the sharp Hb border during cycle 14A: in early stages of this cycle, Bcd cooperative binding is primarily responsible for Hb sharpness; in late cycle 14A, hb self-activation becomes the dominant mechanism. 相似文献
17.
Guillaume Chouinard-Pelletier Mathieu Leduc David Guay Sylvain Coulombe Richard L Leask Elizabeth AV Jones 《Biomedical engineering online》2012,11(1):1-12
Background
Abnormal blood glucose (BG) concentrations have been associated with increased morbidity and mortality in both critically ill adults and infants. Furthermore, hypoglycaemia and glycaemic variability have both been independently linked to mortality in these patients. Continuous Glucose Monitoring (CGM) devices have the potential to improve detection and diagnosis of these glycaemic abnormalities. However, sensor noise is a trade-off of the high measurement rate and must be managed effectively if CGMs are going to be used to monitor, diagnose and potentially help treat glycaemic abnormalities.Aim
To develop a tool that will aid clinicians in identifying unusual CGM behaviour and highlight CGM data that potentially need to be interpreted with care.Methods
CGM data and BG measurements from 50 infants at risk of hypoglycaemia were used. Unusual CGM measurements were classified using a stochastic model based on the kernel density method and historical CGM measurements from the cohort. CGM traces were colour coded with very unusual measurements coloured red, highlighting areas to be interpreted with care. A 5-fold validation of the model was Monte Carlo simulated 25 times to ensure an adequate model fit.Results
The stochastic model was generated using ~67,000 CGM measurements, spread across the glycaemic range ~2-10?mmol/L. A 5-fold validation showed a good model fit: the model 80% confidence interval (CI) captured 83% of clinical CGM data, the model 90% CI captured 91% of clinical CGM data, and the model 99% CI captured 99% of clinical CGM data. Three patient examples show the stochastic classification method in use with 1) A stable, low variability patient which shows no unusual CGM measurements, 2) A patient with a very sudden, short hypoglycaemic event (classified as unusual), and, 3) A patient with very high, potentially un-physiological, glycaemic variability after day 3 of monitoring (classified as very unusual).Conclusions
This study has produced a stochastic model and classification method capable of highlighting unusual CGM behaviour. This method has the potential to classify important glycaemic events (e.g. hypoglycaemia) as true clinical events or sensor noise, and to help identify possible sensor degradation. Colour coded CGM traces convey the information quickly and efficiently, while remaining computationally light enough to be used retrospectively or in real-time. 相似文献18.
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Narayan P Subramaniyam Outi RM Väisänen Katrina E Wendel Jaakko AV Malmivuo 《Nonlinear biomedical physics》2010,4(Z1):S4