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Saeidnia S Gohari AR Ito M Kiuchi F Honda G 《Zeitschrift für Naturforschung. C, Journal of biosciences》2005,60(1-2):22-24
From an EtOAc extract of Dracocephalum subcapitatum, five flavonoids, calycopterin, xanthomicrol, isokaempferide, luteolin and apigenin, together with five terpenoids, oleanolic acid, ursolic acid, geranial, neral and limonene-10-al, were isolated. Among them, citral and limonene-10-al were the most effective components against epimastigotes of Trypanosoma cruzi, the parasitic agent of Chagas disease. 相似文献
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ShahidSales Soodabeh Mehramiz Mehrane Radmanesh Davood Rastgar-Moghadam Azam Hassanian Seyed Mahdi Khazaei Majid Ghazizade Hamideh Ferns Gordon A. Avan Amir 《Molecular biology reports》2020,47(8):6009-6014
Molecular Biology Reports - Breast cancer is among the most common malignancies in women. Recent studies have shown that polymorphisms in genes involved in the metabolism and transport of... 相似文献
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Vahid Zijah Roya Salehi Marziyeh Aghazadeh Mohammad Samiei Effat Alizadeh Soodabeh Davaran 《In vitro cellular & developmental biology. Animal》2017,53(6):502-512
Tissue engineering has emerged as a potential therapeutic option for dental problems in recent years. One of the policies in tissue engineering is to use both scaffolds and additive factors for enhancing cell responses. This study aims to evaluate and compare the effect of three types of biofactors on poly-caprolactone-poly-ethylene glycol-poly caprolactone (PCL-PEG-PCL) nanofibrous scaffold on human dental pulp stem cell (hDPSCs) engineering. The PCL-PEG-PCL copolymer was synthesized with ring opening polymerization method, and its nanofiber scaffold was prepared by electrospinning method. Nanofibrous scaffold-seeded hDPSCs were treated with sodium fluoride (NaF), melanocyte-stimulating hormone (MSH), or simvastatin (SIM). Non-treated nanofiber seeded cells were utilized as control. The viability, biocompatibility, adhesion, proliferation rate, morphology, osteo/odontogenic potential, and the expression of tissue-specific genes were studied. The results showed that significant higher results demonstrated significant higher adhesive behavior, viability, alizarin red activity, and dentin specific gene expression in MSH- and SIM-treated cells (p < 0.05). This study is unique; in that, it compares the effects of different treatments for optimization of dental tissue engineering. 相似文献
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Davaran S Rashidi MR Pourabbas B Dadashzadeh M Haghshenas NM 《International journal of nanomedicine》2006,1(4):535-539
The preparation, properties, and application in adriamycin delivery ofbiocompatible and biodegradable poly(lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) nanoparticles are discussed. PLGA-PEG copolymers were synthesized by ring opening polymerization of the dl-lactide and glycolide in the presence of PEG1000. 1H-NMR and FT-IR spectrum were consistent with the structure of PLGA-PEG copolymers. The adriamycin-loaded nanoparticles could be prepared using a precipitation-solvent evaporation technique. The nanoparticles have been produced by a precipitation-solvent evaporation technique. The physical characteristics and drug loading efficiency of the PLGA-PEG nanoparticles were influenced by the composition of the PLGA-PEG copolymers used to prepare the nanoparticles. Particle sizes were between 65 and 100 nm for different compositions of PLGA-PEG copolymers. PLGA-PEG nanoparticles prepared from copolymers having relatively high PLGA/PEG ratios were smaller. Entrapment efficiency was 25%-33%. Adriamycin release from the nanoparticles at pH 7.4 showed an initial burst release and then sustained release phase. These results showed that PLGA-PEG nanoparticles could be an effective carrier for cancer therapy. 相似文献
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Farhang?Sahba Hamid?R?TizhooshEmail author Magdy?M?Salama 《Biomedical engineering online》2005,4(1):58
Background
In this paper a novel method for prostate segmentation in transrectal ultrasound images is presented. 相似文献26.
Involvement of calcium in interactions between gingival epithelial cells and Porphyromonas gingivalis 总被引:2,自引:0,他引:2
Kenneth T. Izutsu Carol M. Beiton Alex Chan Sahba Fatherazi Jeffrey P. Kanter Yoonsuk Park Richard J. Lamont 《FEMS microbiology letters》1996,144(2-3):145-150
Abstract Three major polypeptides of 34, 48 and 50 kDa which appear to copurify with 1,3-β-glucan synthase activity were isolated by glycerol gradient centrifugation of Chaps-solubilized proteins from the fungus Saprolegnia monoica . The antiserum produced against the 34-kDa polypeptide revealed by protein immunoblotting that this polypeptide copurified with 1,3-β-glucan synthase during enzyme purification. This antiserum adsorbs the enzymatic activity as well as the 48- and 50-kDa polypeptides. These results indicate that the 34-kDa peptide is a component of the multisubunit protein complex involved in 1,3-β-glucan synthase activity. 相似文献
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Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress
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The prognostic value of MGMT promoter methylation in glioblastoma: A meta‐analysis of clinical trials
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Maryam Moradi Binabaj Afsane Bahrami Soodabeh ShahidSales Marjan Joodi Mona Joudi Mashhad Seyed Mahdi Hassanian Kazem Anvari Amir Avan 《Journal of cellular physiology》2018,233(1):378-386
The DNA repair protein O6‐Methylguanine‐DNA methyltransferase (MGMT) is suggested to be associated with resistance to alkylating agents such as Temozolomide which is being used in treatment of patients with glioblastoma (GBM). Therefore, we evaluated the associations between MGMT promoter methylation and prognosis of patients with glioblastoma (GBM). Data were extracted from publications in Embase, PubMed, and the Cochrane Library. Data on overall survival (OS), progression‐free survival (PFS), and MGMT methylation status were obtained and 4,097 subjects were enrolled. Data from 34 studies showed that MGMT methylated patients had better OS, compared to GBM unmethylated patients (pooled HRs, 0.494; 95%CI 0.412–0.591; p = 0.001). Meta‐analysis of 10 eligible studies reporting on PFS, demonstrated that MGMT promoter methylation was not significantly associated with better PFS (pooled HRs, 0.653; 95%CI 0.414–1.030; p = 0.067). GBM patients with MGMT methylation were associated with longer overall survival, although this effect was not detected for PFS. Moreover, we performed further analysis in patients underwent a comprehensive imaging evaluation. This data showed a significant association with better OS and PFS, although further studies are warranted to assess the value of emerging marker in prospective setting in patients with glioblastoma as a risk stratification biomarker in clinical management of the patients. 相似文献