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21.
Meliha Sengezer Inceli Engin Kaptan Serap Sancar Osman Murathanoglu Songul Suren Castillo 《Biologia》2010,65(1):157-163
The dorsal and ventral skin in amphibians plays an important role in osmoregulation. Prolactin hormone is involved in regulation
of amphibian skin functions, such as water and electrolyte balance. Therefore, amphibians may be useful as a model for determining
the sites of the prolactin receptor. In this study, prolactin receptor was detected in frog dorsal and ventral skin using
immunohistochemical staining method. Prolactin receptor immunoreactivity was localized in all epidermal layers except stratum
corneum of dorsal skin epidermis, stratum germinativum layer of ventral skin epidermis, myoepithelial cells, secretory epithelium
and secretory channel cells of granular glands in both skin regions. The mucous glands and secretory granules of granular
glands did not show immunoreactivity for the prolactin receptor. According to our immunohistochemical results, the more widespread
detection of prolactin receptor in dorsal skin epidermis indicates that prolactin is more effective in dorsal skin. Presence
of prolactin receptors in epidermis points out its possible osmoregulatory effect. Moreover, detection of receptor immunoreactivity
in various elements of poison glands in the dermis of both dorsal and ventral skin regions suggests that prolactin has a regulatory
effect in gland functions. 相似文献
22.
Caffeic acid phenethyl ester improves oxidative organ damage in rat model of thermal trauma 总被引:1,自引:0,他引:1
Gurel A Armutcu F Hosnuter M Unalacak M Kargi E Altinyazar C 《Physiological research / Academia Scientiarum Bohemoslovaca》2004,53(6):675-682
Severe burn injuries cause functional impairment in distant internal organs. Although this mechanism is not clear, it is possible that free radical toxicity plays an important role. Research in animals and clinical studies have shown that there is a close relationship between a lipid peroxidative reaction and secondary pathological changes following thermal injury. It has been demonstrated that antioxidant treatment prevents oxidative tissue damage associated with thermal trauma. This study was designed to determine the possible protective effect of caffeic acid phenethyl ester (CAPE) treatment against oxidative damage in the kidney and lung induced by thermal injury. Rats were decapitated either 1, 3 or 7 days after burn injury. CAPE was administered intraperitoneally immediately after thermal injury. Kidney and lung tissues were taken for the determination of malondialdehyde (MDA) level, myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD) and xanthine oxidase (XO) activities. Severe skin thermal injury caused a significant decrease in SOD and CAT activities, as well as significant increases in MDA level, XO and MPO activities in tissues during the postburn period. Treatment of rats with CAPE (10 micromol/kg) significantly elevated the decreased SOD and CAT activities, while it decreased MDA levels and MPO as well as XO activity. 相似文献
23.
Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders. 相似文献
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25.
Abdurrahim Kocyigit Ozcan Erel Mehmet S. Gurel Senel Avci Necmeddim Aktepe 《Biological trace element research》1998,65(3):271-281
The aim of this study was to measure the alterations in serum selenium (Se), copper (Cu), zinc (Zn), and iron (Fe) concentrations
and their carrier proteins, ceruloplasmin (Cp), transferrin (Tf) albumin, and related antioxidant enzyme activities, erythrocyte
Cu-Zn Superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities in patients with cutaneous
leishmaniasis (CL). Erythrocyte Cu-Zn SOD activities, serum Cu concentrations, and Cp levels were found to be significantly
higher in the patients group than those of controls. However, GSH-Px and CAT activities and Se, Zn, Fe, and Tf levels were
lower in patients than in the control subjects. There were positive important correlation’s between Cu-Zn SOD and Cp, Cu-Zn
SOD and Cu, Cp and Cu, GSH-Px and Se, and Fe and CAT in the patients group. Our results showed that serum essential trace
elements Se, Zn, Cu, and Fe concentrations and their related enzymes Cu-Zn SOD, GSH-Px, and CAT activities change in CL patients.
The changes may be a part of defense strategies of organism and are induced by the hormonelike substances. 相似文献
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28.
Sadiye Hayta Ismail Hakki Akgun Markus Ganzera Erdal Bedir Aynur Gurel 《Plant Cell, Tissue and Organ Culture》2011,107(1):175-180
Gentiana cruciata L. (Cross gentian) is a medicinal and ornamental plant, threatened in its natural habitats. The wild root extracts of this
species are known to exhibit many curative properties. In the present study, an efficient protocol for in vitro propagation
of G. cruciata L. was developed from node culture. A semi-solidified Murashige and Skoog (MS) basal medium supplemented with 2.22 μM 6-benzyladenine
(BA), 2.46 μM indole-3-butyric acid (IBA) and sucrose (3% w/v) improved the production of multiple shoots directly from nodal
segments, providing 3.9 shoots per explants on average. The highest rooting (81.7%) was observed with half-strength MS medium
supplemented with 2.46 μM IBA. Plants with well-developed roots were transferred to pots containing turf/vermiculite mixtures
and acclimatized in plant growth chamber conditions. Acclimatized plants showed 100% survival and remained healthy. The content
of secondary metabolites in the clones was determined by HPLC, and the presence of gentiopicroside, loganic acid, swertiamarin,
and sweroside in the samples was confirmed. Gentiopicroside was found to be the major compound. 相似文献
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Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats. 总被引:2,自引:0,他引:2
Zeki Yildirim Yusuf Turkoz Mahir Kotuk Ferah Armutcu Ahmet Gurel Mustafa Iraz Suleyman Ozen Ismet Aydogdu Omer Akyol 《Nitric oxide》2004,11(2):156-165
Reactive oxygen and nitrogen species have been implicated in the pathogenesis of bleomycin-induced lung fibrosis. The effects of aminoguanidine and erdosteine on the bleomycin-induced lung fibrosis were evaluated in rats. The animals were placed into five groups: Vehicle + vehicle, vehicle + bleomycin (2.5 U/kg), bleomycin + aminoguanidine (200 mg/kg), bleomycin + erdosteine (10 mg/kg), and bleomycin + erdosteine + aminoguanidine. Bleomycin administration resulted in prominent lung fibrosis as measured by lung hydroxyproline content and lung histology, which is completely prevented by erdosteine and aminoguanidine. A strong staining for nitro tyrosine antibody in lung tissue and increased levels of lung NO were found in bleomycin group, that were significantly reduced by aminoguanidine and erdosteine. Aminoguanidine and erdosteine significantly prevented depletion of superoxide dismutase and glutathione peroxidase and elevated myeloperoxidase activities, malondialdehyde level in lung tissue produced by bleomycin. Data presented here indicate that aminoguanidine and erdosteine prevented bleomycin-induced lung fibrosis and that nitric oxide mediated tyrosine nitration of proteins plays a significant role in the pathogenesis of bleomycin-induced lung fibrosis. Also our data suggest that antifibrotic affect of antioxidants may be due to their inhibitory effect on nitric oxide generation in this model. 相似文献