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Yueming Zhang Wenrui Zhang Lina Tao Jinghui Zhai Huan Gao Yanqing Song Xiaoyu Qu 《Journal of biochemical and molecular toxicology》2019,33(9)
Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural flavonoid, has been proved to have many medicinal properties. This study aimed to clarify the possible protective effects of Que against INH‐induced hepatotoxicity using HepG2 cells. Our results indicated that Que significantly increased cell viability, superoxide dismutase, and GSH levels, while decreased alanine aminotransferase/aspartate aminotransferase levels. Besides, Que significantly abrogated INH‐induced cell apoptosis by upregulating the expression levels of Bcl‐2 and decreasing the levels of Bax, cleaved caspase‐3, and cleaved caspase‐9. Furthermore, Que obviously reversed the inhibition of INH on Sirtuin 1 (SIRT1) expression and extracellular signal‐regulated kinase (ERK) phosphorylation. Next, the SIRT1 inhibitor EX527 blocked the enhancement of Que upon ERK phosphorylation. Notably, EX527 partially abolished the beneficial effects of Que. In brief, our results provided the first evidence that Que protected against INH‐induced HepG2 cells by regulating the SIRT1/ERK pathway. 相似文献
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Chenchen Ding Wentao Fan Tongtong Shen Kehe Huang Suquan Song Liping Yan 《Journal of biochemical and molecular toxicology》2019,33(1)
In this study, we investigated the influence of zearalenone (ZEA) on the dextran sulfate sodium (DSS)‐induced colitis model both in vitro and in vivo. Our results show that the mRNA levels of IL‐1β, IL‐18, NLRP3, ASC, and caspase‐1 in the DSS+ZEA‐treated group are lower than those in either the DSS or ZEA group, and the protein expression trends are similar. Furthermore, colitis, which is characterized by body weight loss, stool consistency, and the presence of bloody feces, was significantly alleviated in the DSS+ZEA group when compared with that in the DSS group. In addition, histological analysis showed that inflammatory cell infiltration and tissue damage of the colon in the DSS+ZEA group were recovered compared with that in the DSS‐treated group. These results suggest that, instead of aggravating DSS‐induced colitis, ZEA relieves the inflammatory reaction in colon tissue, which may be related to its estrogenic activity. 相似文献
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Cui Heqing Song Myoung Chong Lee Ji Young Yoon Yeo Joon 《Journal of industrial microbiology & biotechnology》2019,46(12):1707-1713
Journal of Industrial Microbiology & Biotechnology - Methylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient... 相似文献
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Ai Chenbing Yan Zhang Chai Hongsheng Gu Tianyuan Wang Junjun Chai Liyuan Qiu Guanzhou Zeng Weimin 《Journal of industrial microbiology & biotechnology》2019,46(8):1113-1127
Journal of Industrial Microbiology & Biotechnology - Extremely thermoacidophilic Crenarchaeota belonging to the order Sulfolobales, such as Metallosphaera sedula, are metabolically versatile... 相似文献
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Song Mei Ling Kim Keun Tae Motamedi Gholam K. Cho Yong Won 《Sleep and biological rhythms》2019,17(4):447-454
Sleep and Biological Rhythms - Narcoleptics tend to have a low quality of life (QoL). Few studies have compared QoL in narcolepsy against other sleep disorders. The purpose of this study was to... 相似文献
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Jun-Jiao Li Lei Zhou Chun-Mei Yin Dan-Dan Zhang Steven J. Klosterman Bao-Li Wang Jian Song Dan Wang Xiao-Ping Hu Krishna V. Subbarao Jie-Yin Chen Xiao-Feng Dai 《Environmental microbiology》2019,21(12):4852-4874
Verticillium dahliae is a soil-borne fungus that causes vascular wilt on numerous plants worldwide. The fungus survives in the soil for up to 14 years by producing melanized microsclerotia. The protective function of melanin in abiotic stresses is well documented. Here, we found that the V. dahliae tetraspan transmembrane protein VdSho1, a homolog of the Saccharomyces cerevisiae Sho1, acts as an osmosensor, and is required for plant penetration and melanin biosynthesis. The deletion mutant ΔSho1 was incubated on a cellophane membrane substrate that mimics the plant epidermis, revealing that the penetration of ΔSho1 strain was reduced compared to the wild-type strain. Furthermore, VdSho1 regulates melanin biosynthesis by a signalling mechanism requiring a kinase-kinase signalling module of Vst50-Vst11-Vst7. Strains, ΔVst50, ΔVst7 and ΔVst11 also displayed defective penetration and melanin production like the ΔSho1 strain. Defects in penetration and melanin production in ΔSho1 were restored by overexpression of Vst50, suggesting that Vst50 lies downstream of VdSho1 in the regulatory pathway governing penetration and melanin biosynthesis. Data analyses revealed that the transmembrane portion of VdSho1 was essential for both membrane penetration and melanin production. This study demonstrates that Vst50-Vst11-Vst7 module regulates VdSho1-mediated plant penetration and melanin production in V. dahliae, contributing to virulence. 相似文献