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451.
Elham Hasanzadeh Somayeh Ebrahimi-Barough Narges Mahmoodi Amir Mellati Houra Nekounam Arefeh Basiri Shiva Asadpour Diba Ghasemi Jafar Ai 《Cell biology international》2021,45(1):140-153
Human endometrial stem cells (hEnSCs) that can be differentiated into various neural cell types have been regarded as a suitable cell population for neural tissue engineering and regenerative medicine. Considering different interactions between hormones, growth factors, and other factors in the neural system, several differentiation protocols have been proposed to direct hEnSCs towards specific neural cells. The 17β-estradiol plays important roles in the processes of development, maturation, and function of nervous system. In the present research, the impact of 17β-estradiol (estrogen, E2) on the neural differentiation of hEnSCs was examined for the first time, based on the expression levels of neural genes and proteins. In this regard, hEnSCs were differentiated into neuron-like cells after exposure to retinoic acid (RA), epidermal growth factor (EGF), and also fibroblast growth factor-2 (FGF2) in the absence or presence of 17β-estradiol. The majority of cells showed a multipolar morphology. In all groups, the expression levels of nestin, Tuj-1 and NF-H (neurofilament heavy polypeptide) (as neural-specific markers) increased during 14 days. According to the outcomes of immunofluorescence (IF) and real-time PCR analyses, the neuron-specific markers were more expressed in the estrogen-treated groups, in comparison with the estrogen-free ones. These findings suggest that 17β-estradiol along with other growth factors can stimulate and upregulate the expression of neural markers during the neuronal differentiation of hEnSCs. Moreover, our findings confirm that hEnSCs can be an appropriate cell source for cell therapy of neurodegenerative diseases and neural tissue engineering. 相似文献
452.
Anahita Kiasatdolatabadi Nasrin Lotfibakhshaiesh Meysam Yazdankhah Somayeh Ebrahimi-Barough Mina Jafarabadi Arman Ai Esmaeil Sadroddiny Jafar Ai 《Molecular neurobiology》2017,54(7):4963-4972
Cerebral palsy (CP) is a neuromuscular disease due to injury in the infant’s brain. The CP disorder causes many neurologic dysfunctions in the patient. Various treatment methods have been used for the management of CP disorder. However, there has been no absolute cure for this condition. Furthermore, some of the procedures which are currently used for relief of symptoms in CP cause discomfort or side effects in the patient. Recently, stem cell therapy has attracted a huge interest as a new therapeutic method for treatment of CP. Several investigations in animal and human with CP have demonstrated positive potential of stem cell transplantation for the treatment of CP disorder. The ultimate goal of this therapeutic method is to harness the regenerative capacity of the stem cells causing a formation of new tissues to replace the damaged tissue. During the recent years, there have been many investigations on stem cell therapy. However, there are still many unclear issues regarding this method and high effort is needed to create a technology as a perfect treatment. This review will discuss the scientific background of stem cell therapy for cerebral palsy including evidences from current clinical trials. 相似文献
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Background
The urokinase plasminogen activator receptor associated protein (uPARAP)/Endo180 is a novel endocytic receptor that mediates collagen uptake and is implicated to play a role in physiological and pathological tissue-remodelling processes by mediating intracellular collagen degradation. 相似文献455.
456.
Salavati Mohammad Ebrahim Rezaeipour Vahid Abdullahpour Rohullah Mousavi Seyed Naser 《International journal of peptide research and therapeutics》2021,27(2):1297-1303
International Journal of Peptide Research and Therapeutics - This study was conducted to evaluate and compare the effects of bioactive peptides derived from sesame meal (BPSM), avilamycin as an... 相似文献
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Somayeh Naghiloo Zahra Esmaillou Gholamreza Gohari Mohammad Reza Dadpour 《Plant Systematics and Evolution》2014,300(2):329-345
The genus Mentha is a taxonomically complex genus, characterized by large morphological variations. Only a few, frequently overlapping, characters are of value in taxonomy. Comparative floral developmental studies provide an opportunity for better understanding the systematic relationships among different species. The inflorescence and floral ontogeny of three Mentha L. species (M. piperita L., M. pulegium L. and M. suaveolens Ehrh.) were investigated using epi-illumination light microscopy. All three species studied have thyrses with the same developmental pathway. The lack of higher order bracts and the monochasial branching of the higher order inflorescence apices were found as special features of inflorescence ontogeny. Sepals appear unidirectionally from the adaxial side in all except for M. pulegium which shows a modified unidirectional sequence. Variable sequences of petal and stamen appearance from unidirectional to reversed unidirectional sequence are present in all. Significant ontogenetic features include (1) appearance of the corolla as a rim before petal lobes become visible and (2) instability in petal aestivation. Morphological features including densely hairy calyx, five-lobed corolla tube, smaller adaxial stamens and hairy ovary with included style distinguish M. pulegium from the other species. On the basis of our results floral ontogenetic features could be considered important characters for delimiting or diagnosing different sections in the genus Mentha. Variable sequences of petal lobe appearance and instability in petal aestivation were found as unusual developmental characters. 相似文献
459.
Somayeh F. Rastegar Nasser L. Hadipour Mohammad Bigdeli Tabar Hamed Soleymanabadi 《Journal of molecular modeling》2013,19(9):3733-3740
The ability of pristine graphene (PG) and Al-doped graphene (AlG) to detect toxic acrolein (C3H4O) was investigated by using density functional calculations. It was found that C3H4O molecule can be adsorbed on the PG and AlG with adsorption energies about ?50.43 and – v30.92 kcal mol?1 corresponding to the most stable configurations, respectively. Despite the fact that interaction of C3H4O has no obvious effects on the of electronic properties of PG, the interaction between C3H4O and AlG can induce significant changes in the HOMO/LUMO energy gap of the sheet, altering its electrical conductivity which is beneficial to sensor designing. Thus, the AlG may be sensitive in the presence of C3H4O molecule and might be used in its sensor devices. Also, applying an external electric filed in an appropriate orientation (almost stronger than 0.01 a.u.) can energetically facilitate the adsorption of C3H4O molecule on the AlG. 相似文献
460.
Pashaei Somayeh Yarani Reza Mohammadi Pantea Emami Aleagha Mohammad Sajad 《Amino acids》2022,54(6):841-858
Amino Acids - Recently, we reviewed the important role of carbohydrates and lipids metabolism in different clinical aspects of multiple sclerosis (MS) disease. In the current paper, we aimed to... 相似文献