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161.
Daneshmandi Saeed Shahrokhi Somayeh 《International journal of peptide research and therapeutics》2019,25(2):427-436
International Journal of Peptide Research and Therapeutics - One of the main problems in tumor therapy is immunosuppressive microenvironment of the tumor. To overcome this, we assessed targeted... 相似文献
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Neurochemical Research - Alzheimer’s disease (AD) is associated with neural oxidative stress and inflammation, and it is assumed to affect more women than men with unknown mechanisms.... 相似文献
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Behzadipour Yasaman Gholampour Maryam Pirhadi Somayeh Seradj Hassan Khoshneviszadeh Mehdi Hemmati Shiva 《International journal of peptide research and therapeutics》2021,27(4):2703-2716
International Journal of Peptide Research and Therapeutics - Viruses of the picornavirus-like supercluster mainly achieve cleavage of polyproteins into mature proteins through viral 3-chymotrypsin... 相似文献
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Mehdi Allahbakhshian-Farsani Narges Abdian Payam Ghasemi-Dehkordi Marzieh Sadeghiani Javad Saffari-Chaleshtori Morteza Hashemzadeh-Chaleshtori Somayeh Khosravi-Farsani 《Cytotechnology》2014,66(5):815-822
Human dermal fibroblasts (HDFs) are a potential source of somatic cells for genetic manipulation and tissue engineering. Confirmation of cytogenetic stability of these cells is an essential step for cell nuclear transfer and generation of a suitable and functional induced pluripotent stem cells line. HDF cells were isolated and cultured from human foreskin samples. Cytogenetic stability of these cells was evaluated in early (3–4) and late (10–15) passages using karyotype test and alkaline comet assay techniques. HDF cells in early and late passages showed normal karyotype but by comet assay abnormality and DNA damages in late passages of HDFs were observed. Also, the parameters of alkaline comet assay in early passages of HDFs compared with late passages and positive control groups more significantly were different (p < 0.05). These findings indicate that single-strand breaks or DNA damage after many passages may have occurred in HDF cells. Our results demonstrate that only early passages of HDF cells maintain cytogenetic stability and are good candidates for gene reprogramming. In conclusion, karyotype testing alone can not be used for detection of all signs of cytogenetic abnormality and DNA damages of cells. So, for precise evaluation of DNA damage and cytogenetic instability of fibroblast cells comet assay and karyotype techniques could complement each other. 相似文献
166.
Somayeh. F. Rastegar Nasser L. Hadipour Hamed Soleymanabadi 《Journal of molecular modeling》2014,20(9):1-6
A density functional theory investigation of adsorption of monomer, dimer and trimer forms of pyrrole on the outer surface of zigzag (7,0) single-walled carbon nanotube (SWCNT) has been reported. Geometries of the complexes were optimized using the M06-2X functional and the 6-31G(d,p) basis set. Moreover, 6-311G(d,p), cc-pVDZ and cc-pVTZ basis sets were used for the adsorption energy calculation and such energies were corrected for the basis set superposition error. Vertical ionization potential and electron affinity of the investigated system were also computed. The interaction of polypyrrole on the SWCNT surface is characterized by the stacking interaction. Adsorption (binding) energy of pyrrole on the SWCNT surface is weak, but such energy increases with the number of monomer units in the pyrrole oligomer. In the SWCNT-pyrrole complexes, the oxidation and reduction processes will take place only at the SWCNT. The influence of larger unit on the electronic properties of the complex has been detailed. 相似文献
167.
A new approach for pancreatic tissue engineering: human endometrial stem cells encapsulated in fibrin gel can differentiate to pancreatic islet beta‐cell
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168.
Masoud Sheidai Somayeh Ziaee Fatemeh Farahani Seyed-Mehdi Talebi Zahra Noormohammadi Yeganeh Hasheminejad-Ahangarani Farahani 《Biologia》2014,69(1):32-39
The genus Linum L. (Lineacea) has over 15 species, subspecies or ecotypes in Iran. These species show extensive geographical distribution and form many local populations throughout the country. Linum album is herbaceous medicinal plant containing important lignans such as podophyllotoxin (PTOX) and 6-methoxy podophyllotoxin (MPTOX), which have antiviral and anticancer properties. Studying the genetic and morphological diversity of different geographical populations produces detailed knowledge about population divergence and identification of the infra-species taxa if at all they are present. Moreover, the populations that differ in their genetic content and structure may also differ in their chemical and medicinal properties. The present study considers morphological and genetic diversity analyses of 20 L. album geographical populations by using nuclear ISSR markers, genome size, and cytogenetic characteristics. These populations differed significantly in many of their quantitative morphological characters and in some of their qualitative features. They also differed significantly in their molecular characteristics and genome size. Details of morphological and molecular variations are reported and discussed. 相似文献
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Talaei Andisheh Mazaheri Somayeh Bayat Elham Bakhshandeh Behnaz Sabzalinejad Masoumeh Damough Shadi Mahboudi Fereidoun Nematollahi Leila Talebkhan Yeganeh 《The protein journal》2021,40(5):786-798
The Protein Journal - With the increasing dominance of monoclonal antibodies (mAbs) in the biopharmaceutical industry and smaller antibody fragments bringing notable advantages over full-length... 相似文献