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排序方式: 共有600条查询结果,搜索用时 156 毫秒
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Soledad Iseas Mariano Golubicki Juan Robbio Gonzalo Ruiz Florencia Guerra Javier Mariani Ruben Salanova Ana Cabanne Martin Eleta Joaquin V. Gonzalez Jorge Basiletti María Alejandra Picconi Guillermo Masciangioli Marcela Carballido Enrique Roca Guillermo Mendez Mariana Coraglio Martin C. Abba 《Translational oncology》2021,14(6)
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with high-risk Human papillomavirus (HPV) infection. Despite improved outcomes in non-metastatic ASCC, definitive chemoradiotherapy constitutes the standard treatment for localized disease. Evidences for predictive and prognostic biomarkers are limited. Here, we performed a viral, immune, and mutational characterization of 79 non-metastatic ASCC patients with complete definitive chemoradiotherapy. HPV-16 was detected in 91% of positive cases in single infections (78%) or in coinfections with multiple genotypes (22%). Fifty-four percent of non-metastatic ASCC cases displayed mutations affecting cancer driver genes such as PIK3CA (21% of cases), TP53 (15%), FBXW7 (9%), and APC (6%). PD-L1 expression was detected in 57% of non-metastatic ASCC. Increased PD-L1 positive cases (67%) were detected in patients with complete response compared with non-complete response to treatment (37%) (p = 0.021). Furthermore, patients with PD-L1 positive tumors were significantly associated with better disease-free survival (DFS) and overall survival (OS) compared with patients with PD-L1 negative tumors (p = 0.006 and p = 0.002, respectively). PD-L1 expression strongly impacts CR rate and survival of non-metastatic ASCC patients after standard definitive chemoradiotherapy. PD-L1 expression could be used to stratify good versus poor responders avoiding the associated morbidity with abdominal perineal resection. 相似文献
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Julieta Soledad Arena María Teresa Defagó 《Entomologia Experimentalis et Applicata》2020,168(5):416-419
This work aimed to identify discriminant morphological characteristics in Alphitobius diaperinus Panzer (Coleoptera: Tenebrionidae) adults that enable live males and females to be distinguished. The method of sexing proposed here is based on dimorphism of the 8th abdominal sternite and is 100% accurate. The method allows differentiation of the sexes non-destructively. 相似文献
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Méndez M. Soledad Martinez M. Laura Araujo Patricia I. Austin Amy T. 《Plant and Soil》2019,442(1-2):483-495
Plant and Soil - The intensity of extreme rainfall events is increasing in many regions of the world, with important impacts on community dynamics and ecosystem functioning especially in... 相似文献
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Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain of Drosophila. 总被引:4,自引:0,他引:4
A long-lived (L) strain of Drosophila melanogaster, derived from a normal-lived (R) strain by artificial selection, has a significantly different adult longevity. Previous work has shown that 1) the two strains age in the same manner, 2) the major genes responsible for much of the L strain's extended longevity are located on the 3rd chromosome, and 3) the extended longevity phenotype is significantly modulated by the larval environment. In this report, we investigate the resistance of the L and R strains to the lethal effects of dietary paraquat. We show that, within the limitations of our described chromosomal and environmental manipulations, the extended longevity phenotype always accompanies the phenotype of elevated paraquat resistance. In addition, reversed selection applied to the L strain results in the simultaneous decrease of both life span and paraquat resistance. Thus, the presence or absence of the latter phenotype may be used as a bioassay for the presence or absence of the extended longevity phenotype, without any necessary implication of causality. Use of this bioassay should greatly speed up the genetic analysis of this system by allowing us to identify long-lived animals at a young age. Finally, we show that the age-related loss of elevated paraquat resistance in both strains precedes all the other age-related functional decrements which we have previously noted in this system. 相似文献