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111.
Asaf Sol Yaniv Skvirsky Rizan Nashef Katya Zelentsova Tal Burstyn-Cohen Edna Blotnick Andras Muhlrad Gilad Bachrach 《The Journal of biological chemistry》2014,289(33):22926-22941
Host defense peptides play an important host-protective role by their microcidal action, immunomodulatory functions, and tissue repair activities. Proteolysis is a common strategy of pathogens used to neutralize host defense peptides. Here, we show that actin, the most abundant structural protein in eukaryotes, binds the LL-37 host defense peptide, protects it from degradation by the proteases of Pseudomonas aeruginosa and Porphyromonas gingivalis, and enables its antimicrobial activity despite the presence of the proteases. Co-localization of LL-37 with extracellular actin was observed in necrotized regions of samples from oral lesions. Competition assays, cross-linking experiments, limited proteolysis, and mass spectrometry revealed that LL-37 binds by specific hydrophobic interactions to the His-40–Lys-50 segment of actin, located in the DNase I binding loop. The integrity of the binding site of both LL-37 and actin is a prerequisite to the binding. Our results demonstrate that actin, presumably released by dead cells and abundant in infected sites, might be utilized by the immune system to enhance spatio-temporal immunity in an attempt to arrest infection and control inflammation. 相似文献
112.
Jie Wu Sol Kim Man Sup Kwak Jang Bin Jeong Hyun Jin Min Ho-Geun Yoon Jin-Hyun Ahn Jeon-Soo Shin 《The Journal of biological chemistry》2014,289(29):20000-20011
113.
Behavioural flexibility predicts invasion success in birds introduced to New Zealand 总被引:13,自引:0,他引:13
A fundamental question in ecology is whether there are evolutionary characteristics of species that make some better than others at invading new communities. In birds, nesting habits, sexually selected traits, migration, clutch size and body mass have been suggested as important variables, but behavioural flexibility is another obvious trait that has received little attention. Behavioural flexibility allows animals to respond more rapidly to environmental changes and can therefore be advantageous when invading novel habitats. Behavioural flexibility is linked to relative brain size and, for foraging, has been operationalised as the number of innovations per taxon reported in the short note sections of ornithology journals. Here, we use data on avian species introduced to New Zealand and test the link between forebrain size, feeding innovation frequency and invasion success. Relative brain size was, as expected, a significant predictor of introduction success, after removing the effect of introduction effort. Species with relatively larger brains tended to be better invaders than species with smaller ones. Introduction effort, migratory strategy and mode of juvenile development were also significant in the models. Pair-wise comparisons of closely related species indicate that successful invaders also showed a higher frequency of foraging innovations in their region of origin. This study provides the first evidence in vertebrates of a general set of traits, behavioural flexibility, that can potentially favour invasion success. 相似文献
114.
Daniel Sol 《Ecography》2000,23(6):687-692
Island communities are generally viewed as being more susceptible to invasion than those of mainland areas, yet empirical evidence is almost lacking. A species-by-species examination of introduced birds in two independent island-mainland comparisons is not consistent with this hypothesis. In the New Zealand-mainland Australia comparison. 16 species were successful in both regions. 19 always failed and only eight had mixed outcomes. Mixed results were observed less often than expected by chance, and in only 5 cases was the relationship in the predicted direction. This result is not biased by differences in introduction effort because, within species, the number of individuals released in New Zealand did not differ significantly from those released in mainland Australia. A similar result emerged in the Hawaiian islands-mainland USA comparison: among the 35 species considered, 15 were successful in both regions, seven always failed and 13 had mixed outcomes. In this occasion, the results fit well to those expected by chance, and in only seven cases was the relationship in the direction predicted. I therefore conclude that, if true, the view that islands are less resistant than continents to invasions is far from universal. 相似文献
115.
116.
Vargas Cartagena L Sánchez E Vargas M Solórzano A Hernández F Iwasawa H Freer E 《Revista de biología tropical》2002,50(1):45-48
"Crespera" is an infectious disease of coffee plants that affects both the coffee production and the economy of the coffee producer countries. This disease affects morphologically the plant: long and narrow leaves with wavy borders and marginal necrosis; strong chlorosis results in drying of the leave, and leads to bad conditions of the plant. The internodes are short, producing the appearance of multiple sprouts in the axial sprout, the flowers can turn greenish, and the plant can present branches with severe symptoms, and branches without apparent symptoms at the same time. As a result, the coffee bean production decreases strikingly. The aim of this work was to determine the occurrence of the possible causative agent in the coffee plants using transmission electron microscopy. Normal and infected plants were compared looking at the leaves, central vein, lateral veins and petiole. It was determined that xylematic vessels show the presence of gram negative bacilliform bacteria (of thick-wavy walls), with dimensions of 0.3-0.5 micron diameter and 1-4 microns, length. The control plants did not show bacteria in the xylem. 相似文献
117.
M Porta J Pumarega L Guarner N Malats R Solà FX Real;for the PANKRAS II Study Group 《Biomarkers》2012,17(6):557-565
We analyzed relationships of hepatic and pancreatic biomarkers with the cholestatic syndrome and tumor stage in exocrine pancreatic cancer (N = 183). Information on laboratory tests and on signs and symptoms was obtained from medical records and patient interviews. Bilirubin, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT) and alkaline phosphatase were lower in tumor stage IV. The association was due to the relationship between cholestatic syndrome and earlier presentation of patients. There was no association between hepatic biomarkers and stage when adjusting by cholestatic syndrome. Relationships of hepatic and pancreatic biomarkers with pancreatic symptoms and tumor stage must be controlled in "-omics" and other studies using biomarkers. 相似文献
118.
N. Belén Rumie Vittar María Julia Lamberti María Florencia Pansa Renzo E. Vera M. Exequiel RodriguezI. Sol Cogno Laura N. Milla SanabriaViviana A. Rivarola 《生物化学与生物物理学报:癌评论》2013
As with natural ecosystems, species within the tumor microenvironment are connected by pairwise interactions (e.g. mutualism, predation) leading to a strong interdependence of different populations on each other. In this review we have identified the ecological roles played by each non-neoplastic population (macrophages, endothelial cells, fibroblasts) and other abiotic components (oxygen, extracellular matrix) directly involved with neoplastic development. A way to alter an ecosystem is to affect other species within the environment that are supporting the growth and survival of the species of interest, here the tumor cells; thus, some features of ecological systems could be exploited for cancer therapy. We propose a well-known antitumor therapy called photodynamic therapy (PDT) as a novel modulator of ecological interactions. We refer to this as “ecological photodynamic therapy.” The main goal of this new strategy is the improvement of therapeutic efficiency through the disruption of ecological networks with the aim of destroying the tumor ecosystem. It is therefore necessary to identify those interactions from which tumor cells get benefit and those by which it is impaired, and then design multitargeted combined photodynamic regimes in order to orchestrate non-neoplastic populations against their neoplastic counterpart. Thus, conceiving the tumor as an ecological system opens avenues for novel approaches on treatment strategies. 相似文献
119.
Does the morphological fit between flowers and pollinators affect pollen deposition? An experimental test in a buzz‐pollinated species with anther dimorphism 下载免费PDF全文
Some pollination systems, such as buzz‐pollination, are associated with floral morphologies that require a close physical interaction between floral sexual organs and insect visitors. In these systems, a pollinator's size relative to the flower may be an important feature determining whether the visitor touches both male and female sexual organs and thus transfers pollen between plants efficiently. To date, few studies have addressed whether in fact the “fit” between flower and pollinator influences pollen transfer, particularly among buzz‐pollinated species. Here we use Solanum rostratum, a buzz‐pollinated plant with dimorphic anthers and mirror‐image flowers, to investigate whether the morphological fit between the pollinator's body and floral morphology influences pollen deposition. We hypothesized that when the size of the pollinator matches the separation between the sexual organs in a flower, more pollen should be transferred to the stigma than when the visitor is either too small or too big relative to the flower. To test this hypothesis, we exposed flowers of S. rostratum with varying levels of separation between sexual organs, to bumblebees (Bombus terrestris) of different sizes. We recorded the number of visits received, pollen deposition, and fruit and seed production. We found higher pollen deposition when bees were the same size or bigger than the separation between anther and stigma within a flower. We found a similar, but not statistically significant pattern for fruit set. In contrast, seed set was more likely to occur when the size of the flower exceeded the size of the bee, suggesting that other postpollination processes may be important in translating pollen receipt to seed set. Our results suggest that the fit between flower and pollinator significantly influences pollen deposition in this buzz‐pollinated species. We speculate that in buzz‐pollinated species where floral morphology and pollinators interact closely, variation in the visitor's size may determine whether it acts mainly as a pollinator or as a pollen thief (i.e., removing pollen rewards but contributing little to pollen deposition and fertilization). 相似文献
120.
Campos F García-Gómez BI Solórzano RM Salazar E Estevez J León P Alvarez-Buylla ER Covarrubias AA 《The Journal of biological chemistry》2001,276(30):28388-28394