排序方式: 共有203条查询结果,搜索用时 156 毫秒
41.
H. Raeisi M. Daliri A. Hosseini E. Kamrani G. H. Moradinasab M. Aghajanpour M. Moein M. Naderi 《Zeitschrift fur angewandte Ichthyologie》2014,30(5):1071-1072
Length–weight relationships (LWRs) for four little‐known fish species collected in the northern Persian Gulf (south of Iran) are presented, namely, Leiognathus lineolatus, Grammoplites suppositus, Eupleurogrammus muticus and Acanthocepola abbreviate. Thus far, these are the first LWRs for these species in the international scientific literature. 相似文献
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Emmanuel K. Nénonéné Fatiha Radja Martin Carli Nico M. van Gelder Soheila Afkhami-Dastjerdian Tomás A. Reader 《Neurochemical research》1996,21(2):167-176
The binding of tritiated 8-hydroxy-2-(di-n-propyl-amino)tetralin, or [3H]8-OH-DPAT, to membranes from rat cerebral cortex and hippocampus could be inhibited by serotonin (5-HT) and buspirone, and
by the 5-HT antagonists propranolol, NAN-190, pindolol, pindobind-5-HT1A, WAY100135, spiperone and ritanserin. All competition curves, except for ritanserin, best fitted a two-site model. In vitro
treatment of the membranes withN-ethylmaleimide (NEM), to alkylate sulfhydryl groups, caused dose-dependent decreases of binding; the inhibition curves were
biphasic, and the effects irreversible. Reduction of disulfide bonds withl-dithiothreitol (L-DTT) also decreased binding, but in a monophasic way; these effects were fully reversible in cortex, but only partially reversible
in hippocampus. In the latter region, but not in cerebral cortex, previous occupancy by [3H]8-OH-DPAT partially protected binding from the effects of bothL-DTT and NEM, suggesting that the thiol groups in the receptor recognition site(s) of this brain region are readily accessible.
The binding characteristics were examined with the aid of saturation curves, carried out with increasing concentrations, up
to 140 nM, of [3H]8-OH-DPAT. The saturation data were suggestive of a two-site receptor model incorporating a high-affinity site (Kh of 0.3–0.5 nM) corresponding to the 5-HT1A receptor, and a low-affinity site (Kl ofca 25 nM). After in vivo alkylations, carried out by treating rats withN-ethoxycarbonyl-2-ethoxy-1,2-dihydro-quinoline (EEDQ), the saturation curves from both control and EEDQ-treated rats were
again best fitted to a two-site model. For EEDQ-treated animals, a drastic decrease of 5-HT1A receptor activity was noted; this loss was greater in hippocampus than in cerebral cortex. Since the decrease in 5-HT1A receptors was not associated with changes in low-affinity binding, the results suggest independent regulations of the two
[3H]8-OH-DPAT binding proteins. Altogether, the present data further supports the notion that [3H]8-OH-DPAT, besides labelling 5-HT1A receptors, also binds to other structures in rat cerebral cortex and hippocampus.
Special issue dedicated to Dr. Kinya Kuriyama 相似文献
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Soheila Ajdary Mohammad Hossein Hosseini Mohammad Hossein Alimohammadian 《Microbiology and immunology》1997,41(3):281-283
Interleukin-1 exacerbates leishmanial lesions in Leishmania major-infected BALB/c mice. Indomethacin can modulate the effect of IL-1, so at least part of the IL-1 effect on disease progression is due to the induction of prostaglandin synthesis. 相似文献
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James A. Gregory Ariel Shepley‐McTaggart Michelle Umpierrez Barry K. Hurlburt Soheila J. Maleki Hugh A. Sampson Stephen P. Mayfield M. Cecilia Berin 《Plant biotechnology journal》2016,14(7):1541-1550
Peanut allergy is an IgE‐mediated adverse reaction to a subset of proteins found in peanuts. Immunotherapy aims to desensitize allergic patients through repeated and escalating exposures for several months to years using extracts or flours. The complex mix of proteins and variability between preparations complicates immunotherapy studies. Moreover, peanut immunotherapy is associated with frequent negative side effects and patients are often at risk of allergic reactions once immunotherapy is discontinued. Allergen‐specific approaches using recombinant proteins are an attractive alternative because they allow more precise dosing and the opportunity to engineer proteins with improved safety profiles. We tested whether Ara h 1 and Ara h 2, two major peanut allergens, could be produced using chloroplast of the unicellular eukaryotic alga, Chlamydomonas reinhardtii. C. reinhardtii is novel host for producing allergens that is genetically tractable, inexpensive and easy to grow, and is able to produce more complex proteins than bacterial hosts. Compared to the native proteins, algal‐produced Ara h 1 core domain and Ara h 2 have a reduced affinity for IgE from peanut‐allergic patients. We further found that immunotherapy using algal‐produced Ara h 1 core domain confers protection from peanut‐induced anaphylaxis in a murine model of peanut allergy. 相似文献
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Fatemeh Tahmasebi Parichehr Pasbakhsh Keywan Mortezaee Soheila Madadi Shirin Barati Iraj Ragerdi Kashani 《Journal of cellular biochemistry》2019,120(6):10576-10586
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). Despite introducing multiple immunomodulatory approaches for MS, there are still major concerns about possible ways for improving remyelination in this disease. Microglia exert essential roles in regulation of myelination processes, and interaction between colony-stimulating factor 1 (CSF1) with its receptor CSF1R is considered as a key regulator of microglial differentiation and survival. The aim of this study was to investigate possible roles for a CSF1R inhibitor PLX3397 in recovery of central myelination processes. Chronic demyelination was induced in mice by addition of 0.2% cuprizone to the chow for 12 weeks. Next, animals were undergoing a diet containing 290 mg/kg PLX3397 to induce microglial ablation. The PLX3397 treatment caused a significant decrease in the rate of expression for the CSF1/CSF1R axis, and a reduction in the protein expressions for the microglial marker Iba-1 and for the oligodendrocyte marker Olig-2. Findings from Luxol fast blue (LFB) staining and transmission electron microscopy (TEM) showed an increase in the rate of myelination for the mice receiving PLX3397. The rate of destruction in the nerve fibers and the extent of the gaps formed between layers of myelin sheaths was also reduced after the treatment with PLX3397. In addition, animals experienced an improvement in recovery of motor deficit after receiving PLX3397 (for all P < 0.05). It could be concluded that PLX3397 could retain myelination in the MS model possibly through regulation of the myelin environment. 相似文献
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Parnian Javad Hoseindokht Maryam Khademi Zahra Moosavi Maedeh Soheili Zahra Soheila Samie Shahram Zomorodipour Alireza 《Biotechnology letters》2022,44(5):713-728
Biotechnology Letters - To improve the expression efficiency of recombinant hFIX, by enhancing its γ-carboxylation, which is inhibited by Calumenin (CALU), we used intronic artificial... 相似文献
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Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss
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Shahin H Walsh T Sobe T Abu Sa'ed J Abu Rayan A Lynch ED Lee MK Avraham KB King MC Kanaan M 《American journal of human genetics》2006,78(1):144-152
In a large consanguineous Palestinian kindred, we previously mapped DFNB28--a locus associated with recessively inherited, prelingual, profound sensorineural hearing impairment--to chromosome 22q13.1. We report here that mutations in a novel 218-kDa isoform of TRIOBP (TRIO and filamentous actin [F-actin] binding protein) are associated with DFNB28 hearing loss in a total of nine Palestinian families. Two nonsense mutations (R347X and Q581X) truncate the protein, and a potentially deleterious missense mutation (G1019R) occurs in a conserved motif in a putative SH3-binding domain. In seven families, 27 deaf individuals are homozygous for one of the nonsense mutations; in two other families, 3 deaf individuals are compound heterozygous for the two nonsense mutations or for Q581X and G1019R. The novel long isoform of TRIOBP has a restricted expression profile, including cochlea, retina, and fetal brain, whereas the original short isoform is widely expressed. Antibodies to TRIOBP reveal expression in sensory cells of the inner ear and colocalization with F-actin along the length of the stereocilia. 相似文献
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Mozhgan Khorasani-Motlagh Meissam Noroozifar Soheila Khajeh 《Inorganica chimica acta》2009,362(10):3785-1294
The molecular structure of praseodymium (III) complex with 1,10-phenanthroline (phen), [Pr(phen)2Cl3·OH2] (1) was determined by single-crystal X-ray diffraction. Crystal data: crystal system, triclinic, space group P and Z = 2, a = 7.1110(7) ?, b = 10.1716(10) ?, c = 17.2367(18) ?, α = 80.922(5)°, β = 78.759(5)°, γ = 70.151(5)°, R1 = 0.036; wR2 = 0.076 for all data. Treatment of aqueous solution of [Pr(phen)2Cl3·OH2] (1) with thallium phenylcyanamide salts yield [Pr(phen)2(L)3] (L = pcyd (2), 2-Clpcyd (3), 2,3,5-Cl3pcyd (4), 2,3,4,5-Cl4pcyd (5)). Four new praseodymium (III) complexes have been characterized by IR, UV-Vis and 1H NMR spectroscopy as well as elemental analysis. The 1H NMR spectra of these complexes show broadening of ligand protons attributed to coordination of paramagnetic center. 相似文献