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The in vitro effect of cisplatin or rIFN-Y on the intracellular free calcium, protein kinase activity and ATP content of non-adherent mononuclear cells (nMNC) from human peripheral blood was assessed. We observed that treatment of nMNC with cisplatin enhanced the [Ca2+]i, ATP level, and protein kinase activity; whereas rIFN-Y-treated nMNC showed significant rises in ATP level and protein kinase activity only. We also observed that cisplatin-treated nMNC showed an instantaneous rise in [Ca2+]i when NK-sensitive K562 cells were added to the effector cells. 相似文献
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U P Singh B N Singh A K Ghose R K Singh A Sodhi 《Journal of inorganic biochemistry》1991,44(4):277-282
Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells. 相似文献
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Overexpression of genes associated with hypoxia in cattle adapted to Trans Himalayan region of Ladakh 总被引:1,自引:0,他引:1 下载免费PDF全文
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Co-Extinctions of Tropical Butterflies and their Hostplants 总被引:4,自引:0,他引:4
The co‐extinction of interdependent species in relation to massive, long–term habitat disturbance has not been thoroughly investigated. Using logistic regression analyses, we examined the relationship between the loss of butterflies and their specific hostplants from the tropical island of Singapore and report the probable occurrence of their co–extinctions at the community level. Our simulation shows that the number of extinct butterfly species is expected to increase exponentially with that of extinct hostplants. The close association between butterflies and their hostplants suggests that the preservation of whole habitats is urgently needed if we are to avoid the possible cascading effects of species (co‐)extinctions. 相似文献
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