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161.
T. L. Karaseva B. A. Lobasyuk S. G. Soboleva E. A. Kostenko S. A. Andronati 《Neurophysiology》2000,32(1):8-11
The neuropharmacological profile of 4-phenyl-1-[4-(2-naphtalimido)butyl]-piperazine (PNBP), a compound that possesses a high
affinity for the serotonin receptors of 1A-type (5-HT1A) and lacks an anxiolytic action, has been studied. Intracerebral administration of PNBP to rats through implanted cannulae
into the hippocampal region resulted in no substantial behavioral changes during “open field” and “conflict situation” tests,
as compared with those of control animals. At the same time, the behavioral effects of intraperitoneal administration of 10
mg/kg buspirone were completely abolished if buspirone had been jointly administered with 10 mg/kg PNBP. Moreover, combined
application of 0.3 mg/kg PNBP and 0.3 mg/kg 8-OH-DPAT, an agonist of 5-HT1A receptors, almost completely abolished the components of “serotonin syndrome” (prone position and stamping of the forepaws)
in animals under study. These findings allowed us to conclude that PNBP has the properties of a competitive antagonist of
buspirone and 8-OH-DPAT. 相似文献
162.
S M Zhenodarova O A Smolianinova I A Soboleva M I Khabarova 《Bioorganicheskaia khimiia》1987,13(8):1023-1030
Immobilized guanyl-specific ribonucleases from Aspergillus clavatus (C2), A. oryzae (T1), and Bacillus intermedius 7P (Bi) have been used for preparative synthesis of ten trinucleoside diphosphates, three tetra- and one pentanucleotide having the only guanylic acid residue at the 5'-end. The nucleotide sequence of the oligonucleotide synthesised determined the choice of the ribonuclease. 相似文献
163.
L F Levina E G Volina G L Soboleva G A Arutiunova 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1983,(8):27-31
The phospholipase activity of leptospires cultivated on serum-lecithin agar has been studied. Two zones of changes in the medium have been found to appear around the colonies of saprophytic Leptospira strains: transparent (5.25 +/- 2.09 mm wide) and turbid (6.90 +/- +/- 1.46 mm wide), which is linked with the production of phospholipases A and C. Only a single clear zone is formed around the colonies of pathogenic strains due to the production of phospholipase A. At the same time virulent Leptospira strains show greater phospholipase activity (the zones are 6.0 +/- 1.2 mm wide) than avirulent strains (the zones are 1.6 +/- +/- 0.04 mm wide). 相似文献