全文获取类型
收费全文 | 2051篇 |
免费 | 226篇 |
国内免费 | 1篇 |
出版年
2021年 | 20篇 |
2017年 | 14篇 |
2016年 | 17篇 |
2015年 | 40篇 |
2014年 | 50篇 |
2013年 | 66篇 |
2012年 | 74篇 |
2011年 | 88篇 |
2010年 | 50篇 |
2009年 | 65篇 |
2008年 | 69篇 |
2007年 | 71篇 |
2006年 | 85篇 |
2005年 | 78篇 |
2004年 | 68篇 |
2003年 | 58篇 |
2002年 | 58篇 |
2001年 | 54篇 |
2000年 | 59篇 |
1999年 | 62篇 |
1998年 | 26篇 |
1997年 | 18篇 |
1996年 | 22篇 |
1995年 | 31篇 |
1994年 | 17篇 |
1993年 | 19篇 |
1992年 | 55篇 |
1991年 | 41篇 |
1990年 | 45篇 |
1989年 | 50篇 |
1988年 | 44篇 |
1987年 | 47篇 |
1986年 | 35篇 |
1985年 | 33篇 |
1984年 | 49篇 |
1983年 | 40篇 |
1982年 | 33篇 |
1981年 | 29篇 |
1980年 | 28篇 |
1979年 | 33篇 |
1978年 | 32篇 |
1977年 | 34篇 |
1976年 | 22篇 |
1975年 | 29篇 |
1974年 | 30篇 |
1973年 | 48篇 |
1972年 | 30篇 |
1971年 | 21篇 |
1970年 | 22篇 |
1969年 | 24篇 |
排序方式: 共有2278条查询结果,搜索用时 15 毫秒
121.
122.
123.
Matthew D. Absher Harman V.S. Peeke Ernest S. Chang Mark J. Snyder 《Marine and Freshwater Behaviour and Physiology》2013,45(2):117-123
Many studies have investigated shell‐related behaviour in hermit crabs. Few studies, however, have focused specifically on the intraspecies aggression associated with shell competition. We examined intraspecies aggression in hermit crab (Pagurus samuelis) pairs as it relates to competition for a limiting resource, gastropod shells. Pairs of hermit crabs were observed in the laboratory in four different treatments that varied the presence or absence of shells for one or both of the crabs. Measurements of the latency to respond, the number of bouts, and the fight durations were recorded. There was a significant difference among treatments for all three measurements, and naked hermit crabs were much more aggressive than housed hermit crabs. There was no significant difference in aggression between males and females in any of the three treatments. The heightened aggression observed in naked P. samuelis is likely in service of acquiring a protective shell. 相似文献
124.
125.
Xiaohua Liu Tiejun Zhu Heng Wang Lipeng Hu Hanhui Xie Guangyu Jiang G. Jeffrey Snyder Xinbing Zhao 《Liver Transplantation》2013,3(9):1238-1244
Understanding the electron and phonon transport characteristics is crucial for designing and developing high performance thermoelectric materials. Weak scattering effects on charge carriers, characterized by deformation potential and alloy scattering potential, are favorable for thermoelectric solid solutions to enable high carrier mobility and thereby promising thermoelectric performance. Mg2(Si,Sn) solid solutions have attracted much attention due to their low cost and environmental compatibility. Usually, their high thermoelectric performance with ZT ~ 1 is ascribed to the band convergence and reduced lattice thermal conductivity caused by alloying. In this work, both a low deformation potential Ξ = 13 eV and a low alloy scattering potential U = 0.7 eV are found for the thermoelectric alloys by characterizing and modeling of thermoelectric transport properties. The band convergence is also verified by the increased density‐of‐states effective mass. It is proposed that, in addition to band convergence and reduced lattice thermal conductivity, the low deformation potential and alloy scattering potential are additional intrinsic features that contribute to the high thermoelectric performance of the solid solutions. 相似文献
126.
Philippe Lefran?ois Raymond K. Auerbach Christopher M. Yellman G. Shirleen Roeder Michael Snyder 《PLoS genetics》2013,9(1)
Accurate chromosome segregation requires centromeres (CENs), the DNA sequences where kinetochores form, to attach chromosomes to microtubules. In contrast to most eukaryotes, which have broad centromeres, Saccharomyces cerevisiae possesses sequence-defined point CENs. Chromatin immunoprecipitation followed by sequencing (ChIP–Seq) reveals colocalization of four kinetochore proteins at novel, discrete, non-centromeric regions, especially when levels of the centromeric histone H3 variant, Cse4 (a.k.a. CENP-A or CenH3), are elevated. These regions of overlapping protein binding enhance the segregation of plasmids and chromosomes and have thus been termed Centromere-Like Regions (CLRs). CLRs form in close proximity to S. cerevisiae CENs and share characteristics typical of both point and regional CENs. CLR sequences are conserved among related budding yeasts. Many genomic features characteristic of CLRs are also associated with these conserved homologous sequences from closely related budding yeasts. These studies provide general and important insights into the origin and evolution of centromeres. 相似文献
127.
128.
Jamie C. Snyder Susan K. Brumfield Keshia M. Kerchner Tessa E. F. Quax David Prangishvili Mark J. Young 《Journal of virology》2013,87(4):2186-2192
Archaeal host cells infected by Sulfolobus turreted icosahedral virus (STIV) and Sulfolobus islandicus rod-shaped virus 2 (SIRV2) produce unusual pyramid-like structures on the cell surface prior to virus-induced cell lysis. This viral lysis process is distinct from known viral lysis processes associated with bacterial or eukaryal viruses. The STIV protein C92 and the SIRV2 protein 98 are the only viral proteins required for the formation of the pyramid lysis structures of STIV and SIRV2, respectively. Since SIRV2 and STIV have fundamentally different morphotypes and genome sequences, it is surprising that they share this lysis system. In this study, we have constructed a collection of C92/P98 chimeric proteins and tested their abilities, both in the context of virus replication and alone, to form pyramid lysis structures in S. solfataricus. The results of this study illustrate that these proteins are functionally homologous when expressed as individual chimeric proteins but not when expressed in the context of complete STIV infection. 相似文献
129.
130.
Ruifeng Zhou Vivian R. Tomkovicz Phillip L. Butler Luis A. Ochoa Zerubbabel J. Peterson Peter M. Snyder 《The Journal of biological chemistry》2013,288(8):5389-5397
Ubiquitination plays a key role in trafficking of the epithelial Na+ channel (ENaC). Previous work indicated that ubiquitination enhances ENaC endocytosis and sorting to lysosomes for degradation. Moreover, a defect in ubiquitination causes Liddle syndrome, an inherited form of hypertension. In this work, we identified a role for USP8 in the control of ENaC ubiquitination and trafficking. USP8 increased ENaC current in Xenopus oocytes and collecting duct epithelia and enhanced ENaC abundance at the cell surface in HEK 293 cells. This resulted from altered endocytic sorting; USP8 abolished ENaC degradation in the endocytic pathway, but it had no effect on ENaC endocytosis. USP8 interacted with ENaC, as detected by co-immunoprecipitation, and it deubiquitinated ENaC. Consistent with a functional role for deubiquitination, mutation of the cytoplasmic lysines of ENaC reduced the effect of USP8 on ENaC cell surface abundance. In contrast to USP8, USP2-45 increased ENaC surface abundance by reducing endocytosis but not degradation. Thus, USP8 and USP2-45 selectively modulate ENaC trafficking at different steps in the endocytic pathway. Together with previous work, the data indicate that the ubiquitination state of ENaC is critical for the regulation of epithelial Na+ absorption. 相似文献